Evidence map›Paper›PMID 30930304›Full record

ArticleActa biomaterialia2019

Enhanced cytocompatibility and antibacterial property of zinc phosphate coating on biodegradable zinc materials.

Yingchao Su, Kai Wang, Julia Gao, Yong Yang, Yi-Xian Qin, Yufeng Zheng, Donghui Zhu

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Acta biomaterialia, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 66 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
66citing papers in PubMed, 1 pooled it
9.1field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

66 citing papers in PubMed, 1 synthesis or guideline pooled it, 252 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Review
  5. Article
  6. Article
  7. Article
  8. Article
  9. Sustainable ZnO/ZnGels (Basel, Switzerland) · 2026
    Article
  10. Review
  11. Article
  12. Article
  13. Review
  14. Article
  15. A long-term quasi-equivalentBioactive materials · 2025
    Article
  16. Review
  17. Article
  18. Article
  19. Article
  20. Bioactive Calcium Silico-Phosphate Glasses Doped with MgAntibiotics (Basel, Switzerland) · 2025
    Article

6 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 2 countries.

Yingchao SuDepartment of Biomedical Engineering, University of North Texas, TX, USA.
Kai WangDepartment of Biomedical Engineering, University of North Texas, TX, USA.
Julia GaoDepartment of Biomedical Engineering, University of North Texas, TX, USA.
Yong YangDepartment of Biomedical Engineering, University of North Texas, TX, USA.
Yi-Xian QinDepartment of Biomedical Engineering, Stony Brook University, New York, USA.
Yufeng ZhengDepartment of Materials Science and Engineering, Peking University, Beijing, China.
Donghui ZhuDepartment of Biomedical Engineering, University of North Texas, TX, USA. Electronic address: Donghui.Zhu@unt.edu.
University of North Texas · USPeking University · CNStony Brook University · US

Funding

Novel surface-modified bioresorbable zinc-based stent materialsR01HL140562 · NHLBI · UNIVERSITY OF NORTH TEXAS · PI Ke Cheng, Donghui Zhu · 2018 to 2026
$4.3M
NHLBI NIH HHS R01 HL140562
6 · The paper itself

Abstract

Zinc (Zn) has recently emerged as a promising biodegradable metal thanks to its critical physiological roles and promising degradation behavior. However, cytocompatibility and antibacterial property of Zn is still suboptimal, in part, due to the excessive Zn ions released during degradation. Inspired by the calcium phosphate-based minerals in natural bone tissue, zinc phosphate (ZnP) coatings were prepared on pure Zn using a chemical conversion method in this study. The coating morphology was then optimized through controlling the pH of coating solution, resulting in a homogeneous micro-/nano-ZnP coating structure. The ZnP coating significantly increased the cell viability, adhesion, and differentiation of pre-osteoblasts and vascular endothelial cells, while significantly reduced the adhesion of the platelets and E. coli. Additionally, ZnP coating significantly reduced the Zn ion release from the bulk material during degradation process, resulting in a much lower Zn

Indexed as

AnimalsAnti-Bacterial AgentsCell AdhesionCell DifferentiationCell LineCell ShapeCell SurvivalCoated Materials, BiocompatibleCorrosionElectrochemistryEscherichia coliFluorescenceHumansMaterials TestingMiceMicrobial Sensitivity TestsAnti-Bacterial AgentsCoated Materials, BiocompatiblePhosphatesZinc Compoundszinc phosphateAntibacterialBiodegradable metalsCytocompatibilityZincZinc phosphate coatings

Identifiers

PMID30930304
PMCPMC6766429
OpenAlexW2928834930

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.