Evidence map›Paper›PMID 30932298›Full record

SynthesisPediatric diabetes2019

Effect of early glycemic control on HbA1c tracking and development of vascular complications after 5 years of childhood onset type 1 diabetes: Systematic review and meta-analysis.

Veena Mazarello Paes, Jessica K Barrett, David C Taylor-Robinson, Heather Chesters, Dimitrios Charalampopoulos, David B Dunger, Russell M Viner, Terence J Stephenson

Open access · hybridAbstract readMeta-AnalysisSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Pediatric diabetes, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed, 4 pooled it
0.6field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 4 syntheses or guidelines pooled it, 20 citations in OpenAlex.

  1. [Diabetes technology (Update 2026)].Wiener klinische Wochenschrift · 2026
    Guideline
  2. Pooled it
  3. Pooled it
  4. Pooled it
  5. Trial
  6. Review
  7. Article
  8. Article
  9. Article
  10. Article
  11. Review
  12. Review
  13. Article
  14. [Insulin pump therapy and continuous glucose monitoring].Wiener klinische Wochenschrift · 2023
    Article
  15. Article
  16. Improved Glycemic Control Observed in Children with Type 1 Diabetes Following the Introduction of Smart Insulin Pens: A Real-World Study.Diabetes therapy : research, treatment and education of diabetes and related disorders · 2022
    Article
  17. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 1 country.

Veena Mazarello PaesGreat Ormond Street Institute of Child Health, University College London, London, UK.ORCID 0000-0002-4283-6266
Jessica K BarrettMRC Biostatistics Unit, University of Cambridge, Cambridge, UK.
David C Taylor-RobinsonInstitute of Population Health Sciences, University of Liverpool, Liverpool, UK.
Heather ChestersGreat Ormond Street Institute of Child Health, University College London, London, UK.
Dimitrios CharalampopoulosGreat Ormond Street Institute of Child Health, University College London, London, UK.
David B DungerDepartment of Paediatrics, University of Cambridge, Cambridge, UK.ORCID 0000-0002-2566-9304
Russell M VinerThe Royal College of Paediatrics and Child Health, London, UK.
Terence J StephensonGreat Ormond Street Institute of Child Health, University College London, London, UK.
Great Ormond Street Hospital · GBUniversity of Cambridge · GBRoyal College of Paediatrics and Child Health · GBUniversity of Liverpool · GB

Funding

British Heart Foundation RG/13/13/30194British Heart Foundation RG/18/13/33946Department of HealthMedical Research Council MC_UU_00002/5Medical Research Council MR/P008577/1
6 · The paper itself

Abstract

objectiveA systematic review and meta-analysis was conducted to investigate if glycemic control measured by glycated hemoglobin (HbA1c) levels near diagnosis are predictive of future glycemic outcomes and vascular complications in childhood onset type 1 diabetes (T1D).

methodsEvidence was gathered using electronic databases (MEDLINE, EMBASE, Web of Science, CINAHL, Scopus, and Cochrane Library up to February 2017) and snowballing techniques. Studies investigating the association between the exposure "early glycemic control" and main outcome: "tracking of early control" and secondary outcome: risk of future complications; in children and young people aged 0 to 19 years at baseline; were systematically double-reviewed, quality assessed, and outcome data extracted for synthesis and meta-analysis.

findingsFive studies (N = 4227 participants) were eligible. HbA1c levels were sub-optimal throughout the study period but tended to stabilize in a "track" by 6 months after T1D diagnosis. The group with low HbA1c <53 mmol/mol (<7%) at baseline had lower long-term HbA1c levels than the higher HbA1c group. The estimated standardized mean difference between the sub groups showed a reduction of HbA1c levels on average by 1.6% (range -0.95% to -2.28%) from baseline. Only one study investigated the association between early glycemic control and development of vascular complications in childhood onset T1D. INTERPRETATIONS: Glycemic control after the first few months of childhood onset T1D, remains stable but sub-optimal for a decade. The low and high HbA1c levels at baseline seem to "track" in their respective tracks during the 10-year follow-up, however, the initial difference between groups narrows over time. PROSPERO: CRD42015024546 http://www.crd.york.ac.uk/PROSPERO/display_record.asp?ID=CRD42015024546.

Indexed as

AdolescentChildDiabetes Mellitus, Type 1Diabetic AngiopathiesGlycated HemoglobinHumansHypoglycemic AgentsGlycated Hemoglobinhemoglobin A1c protein, humanHypoglycemic Agentschildhood-onsetcomplicationsglycemic controlriskT1D

Identifiers

PMID30932298
PMCPMC6701989
OpenAlexW2933543065

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.