Evidence mapPaperPMID 30936147Full record

ArticleDiabetes2019

Altered In Vivo Lipid Fluxes and Cell Dynamics in Subcutaneous Adipose Tissues Are Associated With the Unfavorable Pattern of Fat Distribution in Obese Adolescent Girls.

Jessica Nouws, Mark Fitch, Mariana Mata, Nicola Santoro, Brittany Galuppo, Romy Kursawe, Deepak Narayan, Alla Vash-Margita, Bridget Pierpont, Gerald I Shulman and 2 more

Open access · bronzeAbstract read
In one paragraph

Article in Diabetes, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
1.6field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 23 citations in OpenAlex.

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  10. Pathophysiology of cellulite: Possible involvement of selective endotoxemia.Obesity reviews : an official journal of the International Association for the Study of Obesity · 2023
    Review
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  13. Review
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  15. Article
  16. Dietary carbohydrates and fats in nonalcoholic fatty liver disease.Nature reviews. Gastroenterology & hepatology · 2021
    Review
  17. Article
  18. Article
  19. Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 4 institutions in 1 country.

Jessica NouwsDivision of Pediatric Endocrinology, Department of Pediatrics, Yale University School of Medicine, New Haven, CT.
Mark FitchDepartment of Nutritional Sciences and Toxicology, University of California at Berkeley, Berkeley, CA.
Mariana MataDivision of Pediatric Endocrinology, Department of Pediatrics, Yale University School of Medicine, New Haven, CT.
Nicola SantoroDivision of Pediatric Endocrinology, Department of Pediatrics, Yale University School of Medicine, New Haven, CT.ORCID 0000-0001-6437-4173
Brittany GaluppoDivision of Pediatric Endocrinology, Department of Pediatrics, Yale University School of Medicine, New Haven, CT.
Romy KursaweDiabetes and Obesity, The Jackson Laboratory, Farmington, CT.
Deepak NarayanDivision of Plastic and Reconstructive Surgery, Department of Surgery, Yale University School of Medicine, New Haven, CT.
Alla Vash-MargitaDepartment of Obstetrics, Gynecology and Reproductive Sciences, Yale University School of Medicine, New Haven, CT.
Bridget PierpontDivision of Pediatric Endocrinology, Department of Pediatrics, Yale University School of Medicine, New Haven, CT.
Gerald I ShulmanHoward Hughes Medical Institute, Yale University School of Medicine, New Haven, CT.ORCID 0000-0003-1529-5668
Marc HellersteinDepartment of Nutritional Sciences and Toxicology, University of California at Berkeley, Berkeley, CA.
Sonia CaprioDivision of Pediatric Endocrinology, Department of Pediatrics, Yale University School of Medicine, New Haven, CT sonia.caprio@yale.edu.ORCID 0000-0002-7523-5053
Yale University · USUniversity of California, Berkeley · USHoward Hughes Medical Institute · USJackson Laboratory · US

Funding

Yale Clinical and Translational Science Award (U Component)UL1TR001863 · NCATS · YALE UNIVERSITY · PI John H. Krystal, LUCILA OHNO-MACHADO · 2016 to 2026
$102.9M
YALE UNIVERSITY CLINICAL AND TRANSLATIONAL SCIENCE AWARD PROGRAMUL1RR024139 · NCRR · YALE UNIVERSITY · PI SHERWIN, ROBERT S · 2006 to 2011
$56.8M
Yale Diabetes Research CenterP30DK045735 · NIDDK · YALE UNIVERSITY · PI GERALD I SHULMAN · 1993 to 2026
$44.0M
METABOLIC PREDICTORS AND MARKERS OF CHILDHOOD OBESITYR01HD028016 · NICHD · YALE UNIVERSITY · PI CAPRIO, SONIA · 1991 to 2024
$8.9M
Genetic and Cellular Mechanisms of NAFLD and Hepatic Insulin ResistanceR24DK085638 · NIDDK · YALE UNIVERSITY · PI SHULMAN, GERALD I · 2010 to 2014
$6.3M
Study to Investigate the Pathophysiology of Type 2 Diabetes in YouthR01HD040787 · NICHD · YALE UNIVERSITY · PI CAPRIO, SONIA · 2000 to 2014
$5.6M
NMR STUDIES OF GLYCOGEN METABOLISM IN HUMANSR01DK049230 · NIDDK · YALE UNIVERSITY · PI SHULMAN, GERALD I · 1995 to 2014
$5.4M
Bioimage Suite: A structural, functional and metabolic image analysis platformR01EB006494 · NIBIB · YALE UNIVERSITY · PI PAPADEMETRIS, XENOPHON · 2006 to 2009
$1.5M
PATHOPHYSIOLOGY OF METABOLIC DEFECTS OF JUVENILE OBESITYK24HD001464 · NICHD · YALE UNIVERSITY · PI CAPRIO, SONIA · 2001 to 2010
$1.4M
NCATS NIH HHS UL1 TR001863NCRR NIH HHS UL1 RR024139NIBIB NIH HHS R01 EB006494NICHD NIH HHS K24 HD001464NICHD NIH HHS R01 HD028016NICHD NIH HHS R01 HD040787NIDDK NIH HHS P30 DK045735NIDDK NIH HHS R01 DK049230NIDDK NIH HHS R24 DK085638
6 · The paper itself

Abstract

Patterns of abdominal fat distribution (for example, a high vs. low visceral adipose tissue [VAT]/[VAT + subcutaneous adipose tissue (SAT)] ratio), independent of obesity, during adolescence carry a high risk for insulin resistance and type 2 diabetes. Longitudinal follow-up of a cohort of obese adolescents has recently revealed that a high ratio (high VAT/[VAT + SAT]) is a major determinant of fatty liver and metabolic impairment over time, with these effects being more pronounced in girls than in boys. To unravel the underlying metabolic alterations associated with the unfavorable VAT/(VAT + SAT) phenotype, we used the

Indexed as

Body Fat DistributionAbsorptiometry, PhotonAdipocytesAdolescentDeuterium OxideFemaleHumansIntra-Abdominal FatLipid MetabolismLipogenesisMagnetic Resonance ImagingObesityObesity, AbdominalSubcutaneous FatTriglyceridesYoung AdultDeuterium OxideTriglycerides

Identifiers

PMID30936147
PMCPMC6610014
OpenAlexW2928353160

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.