ArticleAnalytical biochemistry2019
Fast LC-MS quantitation of glucose and glycerol via enzymatic derivatization.
Article in Analytical biochemistry, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed, 25 citations in OpenAlex.
- Design and Optimization of a Glucose Fluorescence Nano-biosensor Based on Graft Copolymer of Poly(acrylic acid)-co-(vinyl phenyl boronic acid)-g-gelatin to Modify CdTe/TGA QDs.Journal of fluorescence · 2026Article
- Sexual dimorphism shapes renal metabolic adaptation to a ketogenic diet.Cell reports · 2026Article
- Discovery and application of food catalysts to promote the coupling of PQQ (quinone) with amines.Frontiers in nutrition · 2024Article
- Activation induces shift in nutrient utilization that differentially impacts cell functions in human neutrophils.bioRxiv : the preprint server for biology · 2023Article
- Two-dimensional isomer differentiation using liquid chromatography-tandem mass spectrometry with in-source, droplet-based derivatization.The Analyst · 2023Article
- Differential Metabolism of Glycerol Based on Oral versus Intravenous Administration in Humans.Metabolites · 2022Article
- Glycerol not lactate is the major net carbon source for gluconeogenesis in mice during both short and prolonged fasting.Molecular metabolism · 2020Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
Glucose and glycerol are important circulating metabolites. Due to poor ionization and/or ion suppression, the liquid chromatography-mass spectrometry (LC-MS) detection of glucose and glycerol presents challenges. Here, we propose an efficient LC-MS method of quantitative glucose and glycerol detection via enzymatic derivatization to glucose-6-phosphate and sn-glycerol-3-phosphate, respectively. This derivatization protocol can be used to measure the concentrations of glucose production in a plethora of sample types for metabolic analysis and is compatible with the general metabolomics workflow. This novel approach allows us to quantitatively study glucose and glycerol metabolism using stable isotope tracers in vivo.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.