Evidence map›Paper›PMID 30941017›Full record

ArticleFrontiers in cellular neuroscience2019

Mitochondrial Dysfunction in Huntington's Disease; Interplay Between HSF1, p53 and PGC-1α Transcription Factors.

Taylor A Intihar, Elisa A Martinez, Rocio Gomez-Pastor

Open access · goldAbstract read
In one paragraph

Article in Frontiers in cellular neuroscience, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 48 papers.

0numbers the graph read from it
0cells of the map it votes in
48citing papers in PubMed
6.2field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

48 citing papers in PubMed, 98 citations in OpenAlex.

  1. Article
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  10. Article
  11. Calcium Ions in the Physiology and Pathology of the Central Nervous System.International journal of molecular sciences · 2024
    Review
  12. Review
  13. Review
  14. Review
  15. Article
  16. Review
  17. Mitochondrial Dysfunction in Repeat Expansion Diseases.Antioxidants (Basel, Switzerland) · 2023
    Review
  18. Article
  19. Review
  20. HSF1 and Its Role in Huntington's Disease Pathology.Advances in experimental medicine and biology · 2023
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

Taylor A IntiharDepartment of Neuroscience, School of Medicine, University of Minnesota, Minneapolis, MN, United States.
Elisa A MartinezDepartment of Biochemistry and Molecular Biology, Dickinson College, Carlisle, PA, United States.
Rocio Gomez-PastorDepartment of Neuroscience, School of Medicine, University of Minnesota, Minneapolis, MN, United States.
University of Minnesota · USDickinson College · US

Funding

Molecular mechanisms of synaptic dysfunction and cognitive decline in Huntington's diseaseR01NS110694 · NINDS · UNIVERSITY OF MINNESOTA · PI Rocio Gomez-Pastor · 2020 to 2026
$3.1M
University of Minnesota Summer Research in NeuroscienceR25NS083059 · NINDS · UNIVERSITY OF MINNESOTA · PI Alfonso Araque, Angeline Joan Dukes · 2013 to 2026
$1.2M
NINDS NIH HHS R01 NS110694NINDS NIH HHS R25 NS083059
6 · The paper itself

Abstract

Huntington's disease (HD) is a neurodegenerative disease caused by an expanded CAG repeat in the huntingtin (

Indexed as

heat shock factor 1 (HSF1)Huntington (disease)mitochondrial dysfunctionp53PGC-1α

Identifiers

PMID30941017
PMCPMC6433789
OpenAlexW2922867578

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.