ArticleScientific reports2019
Genetic association of LPL rs1121923 and rs258 with plasma TG and VLDL levels.
Article in Scientific reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed.
- Interpretable deep survival analysis of Alzheimer's disease via metabolic genetic variants.Bioinformatics (Oxford, England) · 2026Article
- Lipoprotein Lipase Genetic Variants rs258 and rs326 Differentially Affect Lipid Profiles and Leptin Levels in Prepubertal Spanish Caucasian Children.Journal of clinical medicine · 2026Article
- High unprocessed beef intake (>100 g/d) linked to elevated triglyceride levels: evidence from cross-sectional and Mendelian randomization in Chinese and American adult populations.Frontiers in nutrition · 2026Article
- Association of Lipoprotein Lipase (International journal of molecular sciences · 2025Article
- A Set of Proximal Regulatory Elements Contribute to the Transcriptional Activity of the Human Lipoprotein Lipase Promoter.Current issues in molecular biology · 2024Article
- The Association of Adipokines and Myokines in the Blood of Obese Children and Adolescents with Lipoprotein Lipase rs328 Gene Variants.Journal of obesity · 2023Article
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Authors and funding
5 authors.
Funding
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Abstract
Lipoprotein lipase (LPL) is a rate-limiting enzyme for the hydrolysis of triglycerides (TG). Hundreds of genetic variants including single nucleotide polymorphisms have been identified across the 30Kb gene locus on chromosome 8q22. Several of these variants have been demonstrated to have genetic association with lipid level variation but many remain unresolved. Controversial reports on the genetic association of variants among different populations pose a challenge to which variants are informative. This study aimed to investigate "common" LPL variants (rs1121923, rs258, rs328, rs13702) and their possible role in plasma lipid level. Genotyping was performed using Realtime PCR. Based on the observed genotypes, the minor allele frequencies were A: 0.065 for rs1121923; C: 0.379 for rs258; G: 0.087 for rs328 and C: 0.337 for rs13702. Using linear regression, a lowering effect of rs1121923 (p = 0.024) on TG levels (-0.14 B coefficient: CI: -0.27--0.019) and rs258 (p = 0.013) on VLDL levels (B: -0.046; CI: -0.082--0.009) was observed indicating a "protective" role for the two variants. Moreover, the findings indicate the potential for including rs1121923 and rs258 in diagnostic panels for use as an estimator of "risk" scores for dyslipidemia.
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