Evidence map›Paper›PMID 30944413›Full record

ReviewNature reviews. Microbiology2019

Bacterial quorum sensing in complex and dynamically changing environments.

Sampriti Mukherjee, Bonnie L Bassler

Abstract readReview
In one paragraph

Review in Nature reviews. Microbiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 581 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
581citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

581 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
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  9. Revisiting the life cycle of temperate phages.Nature reviews. Microbiology · 2026
    Review
  10. Article
  11. Bacilli the most important biocontrol agent in Brazilian agriculture: from mechanisms of action to market adoption.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2026
    Review
  12. Article
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521 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Sampriti MukherjeePrinceton University, Department of Molecular Biology, Princeton, NJ, USA.
Bonnie L BasslerPrinceton University, Department of Molecular Biology, Princeton, NJ, USA. bbassler@princeton.edu.ORCID http://orcid.org/0000-0002-0043-746X

Funding

Intra-and Inter-Species Communication in BacteriaR01GM065859 · NIGMS · PRINCETON UNIVERSITY · PI BASSLER, BONNIE L · 2002 to 2015
$4.2M
Intra- and Inter- Species Communication in BacteriaR37GM065859 · NIGMS · PRINCETON UNIVERSITY · PI BASSLER, BONNIE L · 2016 to 2025
$3.4M
A new quorum-sensing autoinducer acts with the RhlR receptor to control virulence and biofilms in Pseudomonas aeruginosaK99GM129424 · NIGMS · PRINCETON UNIVERSITY · PI MUKHERJEE, SAMPRITI · 2018 to 2019
$180k
NIGMS NIH HHS K99 GM129424NIGMS NIH HHS R01 GM065859NIGMS NIH HHS R37 GM065859
6 · The paper itself

Abstract

Quorum sensing is a process of bacterial cell-to-cell chemical communication that relies on the production, detection and response to extracellular signalling molecules called autoinducers. Quorum sensing allows groups of bacteria to synchronously alter behaviour in response to changes in the population density and species composition of the vicinal community. Quorum-sensing-mediated communication is now understood to be the norm in the bacterial world. Elegant research has defined quorum-sensing components and their interactions, for the most part, under ideal and highly controlled conditions. Indeed, these seminal studies laid the foundations for the field. In this Review, we highlight new findings concerning how bacteria deploy quorum sensing in realistic scenarios that mimic nature. We focus on how quorums are detected and how quorum sensing controls group behaviours in complex and dynamically changing environments such as multi-species bacterial communities, in the presence of flow, in 3D non-uniform biofilms and in hosts during infection.

Indexed as

Bacterial Physiological PhenomenaBiofilmsHost Microbial InteractionsMicrobiotaQuorum Sensing

Identifiers

PMID30944413
PMCPMC6615036

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.