ReviewOncology letters2019
Acanthosis nigricans: To be or not to be afraid.
Review in Oncology letters, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it, 38 citations in OpenAlex.
- Efficacy and safety of lasers versus topical medications for acanthosis nigricans and pseudo-acanthosis nigricans treatment: a systematic review.Lasers in medical science · 2024Pooled it
- Clinical and Dermoscopic Evaluation of the Effectiveness of Metformin versus Pioglitazone in Acanthosis Nigricans: A Randomised Controlled Trial.Indian dermatology online journal · 2026Article
- Unlocking the Sugar Code: Implications and Consequences of Glycosylation in Alzheimer's Disease and Other Tauopathies.Biomedicines · 2025Review
- Artificial Intelligence-Assisted Dermatologic Screening: Epidemiology and Clinical Features of Basal Cell Carcinoma, Squamous Cell Carcinoma, Seborrheic Keratosis and Actinic Keratosis.Bioengineering (Basel, Switzerland) · 2025Review
- Metabolic syndrome and dermatological diseases: association and treatment.Nutrition & metabolism · 2025Review
- Review
- Modern Digital Query Analytics of Patient Education Materials on Acanthosis Nigricans: Systematic Search and Content Analysis.JMIR dermatology · 2025Article
- Cutaneous manifestations of diabetes mellitus: a narrative review.Einstein (Sao Paulo, Brazil) · 2025Review
- Trichloroacetic Acid 15% Peel Alone versus in Combination with Microneedling in Patients with Acanthosis Nigricans.The Journal of clinical and aesthetic dermatology · 2024Article
- Grading Acanthosis Nigricans Using a Smartphone and Color Analysis: A Novel Noninvasive Method to Screen for Impaired Glucose Tolerance and Type 2 Diabetes.Diabetes spectrum : a publication of the American Diabetes Association · 2024Article
- Crouzon syndrome with acanthosis nigricans: a case report and literature review.Dermatology reports · 2023Article
- Acanthosis nigricans in the setting of severe pulmonary disease exacerbated by COVID-19 infection.JAAD case reports · 2022Article
- Acanthosis nigricans in a patient with metastatic insulinoma post peptide receptor radionuclide therapy.Endocrinology, diabetes & metabolism case reports · 2022Article
- Acanthosis nigricans in the pediatric population: a narrative review of the current approach to management in primary care.Pediatric medicine (Hong Kong, China) · 2022Article
- [Correlation between total testosterone levels and insulin resistance in patients with acanthosis nigricans and non-acanthosis nigrican].Nan fang yi ke da xue xue bao = Journal of Southern Medical University · 2021Article
- [Hyperplasia-associated cutaneous paraneoplasia].Der Hautarzt; Zeitschrift fur Dermatologie, Venerologie, und verwandte Gebiete · 2021Review
- COVID-19 and diabetes mellitus: Unraveling the hypotheses that worsen the prognosis (Review).Experimental and therapeutic medicine · 2020Review
- Beneficial effects of food supplements based on hydrolyzed collagen for skin care (Review).Experimental and therapeutic medicine · 2020Review
- The 2nd Conference of the Romanian Society of Immuno-Dermatology, Bucharest, September 27-29, 2018.Oncology letters · 2019Article
- Diffuse Esophageal Squamous Papillomatosis: A Rare Disease Associated with Acanthosis Nigricans and Tripe Palms.Case reports in gastroenterologyArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Acanthosis nigricans (AN), a skin disorder with high prevalence, represents a dermatological condition with esthetic implications, but otherwise mild symptoms. For any clinician, it is in fact the tip of the iceberg, leading him/her to investigate what lies beneath the surface, since AN points to a systemic problem or disease: metabolic disorder (most frequently), endocrine syndrome, medication side effects, malignancy, and genetic factors. Sometimes, it is the first observed sign of a malignancy or of diabetes mellitus, especially in patients with chronic metabolic disorder; therefore, it is not to be taken lightly. The present review summarizes the information in literature regarding the etiopathogenesis of AN. We propose a new classification that aims to better organize the different types of AN, with implications on the extent and urgency of the investigation plan, as well as various therapeutic algorithms. Therapy options are also presented, both systemic treatments that target the underlying disease, and local ones for esthetic reasons.
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What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.