Evidence map›Paper›PMID 30948457›Full record

ArticleEMBO reports2019

Gadd45α modulates aversive learning through post-transcriptional regulation of memory-related mRNAs.

Alejandro Aparisi Rey, Emil Karaulanov, Salim Sharopov, Khelifa Arab, Andrea Schäfer, Mathias Gierl, Stephan Guggenhuber, Caroline Brandes, Luigi Pennella, Wolfram H Gruhn and 7 more

Open access · hybridAbstract read
In one paragraph

Article in EMBO reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
0.8field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 20 citations in OpenAlex.

  1. Article
  2. Role of CPEBs in Learning and Memory.Journal of neurochemistry · 2025
    Review
  3. Review
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  5. Review
  6. Deletion ofInternational journal of molecular sciences · 2024
    Article
  7. Review
  8. Review
  9. Article
  10. Cannabinoid CB1 receptor in dorsal telencephalic glutamatergic neurons drives overconsumption of palatable food and obesity.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 3 institutions in 1 country.

Alejandro Aparisi ReyInstitute of Physiological Chemistry, University Medical Center of the Johannes Gutenberg University Mainz, Mainz, Germany.
Emil KaraulanovInstitute of Molecular Biology, Mainz, Germany.
Salim SharopovInstitute of Physiology, University Medical Center of the Johannes Gutenberg University Mainz, Mainz, Germany.
Khelifa ArabInstitute of Molecular Biology, Mainz, Germany.
Andrea SchäferInstitute of Molecular Biology, Mainz, Germany.
Mathias GierlInstitute of Molecular Biology, Mainz, Germany.
Stephan GuggenhuberInstitute of Physiological Chemistry, University Medical Center of the Johannes Gutenberg University Mainz, Mainz, Germany.
Caroline BrandesInstitute of Physiological Chemistry, University Medical Center of the Johannes Gutenberg University Mainz, Mainz, Germany.
Luigi PennellaInstitute of Physiological Chemistry, University Medical Center of the Johannes Gutenberg University Mainz, Mainz, Germany.
Wolfram H GruhnInstitute of Molecular Biology, Mainz, Germany.
Ruth JelinekInstitute of Physiological Chemistry, University Medical Center of the Johannes Gutenberg University Mainz, Mainz, Germany.
Christina MaulInstitute of Physiological Chemistry, University Medical Center of the Johannes Gutenberg University Mainz, Mainz, Germany.
Andrea ConradInstitute of Physiological Chemistry, University Medical Center of the Johannes Gutenberg University Mainz, Mainz, Germany.
Werner KilbInstitute of Physiology, University Medical Center of the Johannes Gutenberg University Mainz, Mainz, Germany.
Heiko J LuhmannInstitute of Physiology, University Medical Center of the Johannes Gutenberg University Mainz, Mainz, Germany.
Christof NiehrsInstitute of Molecular Biology, Mainz, Germany c.niehrs@imb-mainz.de beat.lutz@uni-mainz.de.ORCID 0000-0002-9561-9302
Beat LutzInstitute of Physiological Chemistry, University Medical Center of the Johannes Gutenberg University Mainz, Mainz, Germany c.niehrs@imb-mainz.de beat.lutz@uni-mainz.de.ORCID 0000-0002-1062-6889
Johannes Gutenberg University Mainz · DEInstitute of Molecular Biology · DEGerman Cancer Research Center · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Learning is essential for survival and is controlled by complex molecular mechanisms including regulation of newly synthesized mRNAs that are required to modify synaptic functions. Despite the well-known role of RNA-binding proteins (RBPs) in mRNA functionality, their detailed regulation during memory consolidation is poorly understood. This study focuses on the brain function of the RBP Gadd45α (growth arrest and DNA damage-inducible protein 45 alpha, encoded by the

Indexed as

Gene Expression RegulationLearningMemoryAmygdalaAnimalsBehavior, AnimalCell Cycle ProteinsGADD45 ProteinsGene ExpressionHippocampusMiceMice, KnockoutNeuronal PlasticityPain ThresholdRNA InterferenceRNA, MessengerCell Cycle ProteinsGadd45a protein, mouseGADD45 ProteinsRNA, MessengerGadd45aGrin2amemoryRNA stability

Identifiers

PMID30948457
PMCPMC6549022
OpenAlexW2934491044

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.