Evidence map›Paper›PMID 30957240›Full record

Trial reportHealth services research2019

Tailored interventions by community pharmacists and general practitioners improve adherence to statins in a Spanish randomized controlled trial.

Ainhoa Oñatibia-Astibia, Amaia Malet-Larrea, Belen Larrañaga, Miguel Ángel Gastelurrutia, Begoña Calvo, Dulce Ramírez, Ignacio Cantero, Ángel Garay, Estibaliz Goyenechea

Open access · bronzeAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Health services research, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed, 1 pooled it
3.8field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 1 synthesis or guideline pooled it, 28 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 1 country.

Ainhoa Oñatibia-AstibiaOfficial Pharmacist Association of Gipuzkoa, Donostia/San Sebastián, Spain.ORCID 0000-0002-1726-6943
Amaia Malet-LarreaOfficial Pharmacist Association of Gipuzkoa, Donostia/San Sebastián, Spain.
Belen LarrañagaOfficial Pharmacist Association of Gipuzkoa, Donostia/San Sebastián, Spain.
Miguel Ángel GastelurrutiaPharmaceutical Care Research Group, Faculty of Pharmacy, University of Granada, Granada, Spain.
Begoña CalvoPharmaceutical Technology Department, Faculty of Pharmacy, University of the Basque Country, Vitoria, Spain.
Dulce RamírezTreatment Adherence Observatory, Madrid, Spain.
Ignacio CanteroTreatment Adherence Observatory, Madrid, Spain.
Ángel GarayOfficial Pharmacist Association of Gipuzkoa, Donostia/San Sebastián, Spain.
Estibaliz GoyenecheaOfficial Pharmacist Association of Gipuzkoa, Donostia/San Sebastián, Spain.
Onkologikoa · ESFundación Botín · ESUniversidad de Granada · ESUniversity of the Basque Country · ES

Funding

TEVA PHARMA S.L.
6 · The paper itself

Abstract

objectiveTo evaluate the impact of health professionals' intervention on adherence to statins, the influence on total cholesterol levels, and lifestyle patterns in patients with hypercholesterolemia and analyze the differences according to the center of recruitment. STUDY

settingForty-six community pharmacies and 50 primary care centers of Spain. STUDY

designRandomized controlled trial design (n = 746). Patients were assigned into adherent (ADH) or nonadherent group depending on their initial adherence to statins. Nonadherent patients were randomly assigned to intervention (INT) or nonintervention (NOINT) group. Patients enrolled in the INT group received an intervention depending on the cause of nonadherence. Patients in the ADH and NOINT groups received usual care. Intention-to-treat (ITT) analysis was performed with multiple imputation to replace the missing data. DATA COLLECTION: Adherence, total cholesterol levels, and lifestyle behaviors.

findingsThe odds of becoming adherent during the 6 months was higher in the INT group compared to the NOINT group (OR = 1,49; 95% CI: 1.30-1.76; P < 0.001), especially in the community pharmacy group (OR = 2.34; 95% CI: 1.81-3.03; P < 0.001). Adherent patients showed lower values of total cholesterol compared with nonadherent patients at baseline (ADH: 200.3 mg/dL vs NOADH: 216.7 mg/dL; P < 0.001) and at the endpoint (ADH: 197.3 mg/dL vs NOADH: 212.2 mg/dL; P < 0.001). More patients enrolled in the INT group practices exercise at the end of the study (INT: +26.6 percent; P = 0.002), and a greater number of patients followed a diet to treat hypercholesterolemia (+30.2 percent; P < 0.001).

conclusionsThe intervention performed by health professionals, especially by community pharmacists, improved adherence to statins by hypercholesterolemic patients, and this improvement in adherence was accompanied by a reduction in total cholesterol levels and a healthier lifestyle.

Indexed as

Drug MonitoringAgedCholesterolFemaleGeneral PractitionersHealth Knowledge, Attitudes, PracticeHumansHydroxymethylglutaryl-CoA Reductase InhibitorsHypercholesterolemiaLife StyleMaleMiddle AgedPharmacistsSocioeconomic FactorsSpainCholesterolHydroxymethylglutaryl-CoA Reductase Inhibitorsclinical outcomescommunity pharmacycompliancehypercholesterolemialipid-lowering drugs

Identifiers

PMID30957240
PMCPMC6505412
OpenAlexW2937898739

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.