Evidence mapPaperPMID 30958402Full record

ReviewCurrent opinion in anaesthesiology2019

Recent advances in diabetes treatments and their perioperative implications.

Deniz Kuzulugil, Gabrielle Papeix, Judy Luu, Ross K Kerridge

Registry-linked trialOpen access · hybridAbstract readReview
In one paragraph

Review in Current opinion in anaesthesiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04284722 (Perioperative Continuation of Metformin Therapy in Patients With Typ 2 Diabetes Mellitus Undergoing Non-cardiac Surgery), which is not on this map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
3.2field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04284722 phase4unknown statusstarted 2020, after this paper: background citation

Perioperative Continuation of Metformin Therapy in Patients With Typ 2 Diabetes Mellitus Undergoing Non-cardiac Surgery

Ran2020Enrolled400Registered outcomes8Posted comparisons0ConditionsHyperglycemia, Hyperlactatemia, Metformin, Type 2 DiabetesArmsMetformin hydrochloride
PMID 28940961PMID 30044293PMID 20393934other papers from this trial
Open the trial in the graph
3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 41 citations in OpenAlex.

  1. [Hospital diabetes management (Update 2026)].Wiener klinische Wochenschrift · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Deniz KuzulugilDepartment of Endocrinology, John Hunter Hospital.
Gabrielle PapeixDepartment of Anaesthesia & Perioperative Medicine, John Hunter Hospital.
Judy LuuDepartment of Endocrinology, John Hunter Hospital.
Ross K KerridgeDepartment of Anaesthesia & Perioperative Medicine, John Hunter Hospital.
John Hunter Hospital · AUUniversity of Newcastle Australia · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purpose of reviewThe implications for perioperative management of new oral antihyperglycemic medications and new insulin treatment technologies are reviewed. RECENT

findingsThe preoperative period represents an opportunity to optimize glycemic control and potentially to reduce adverse outcomes. There is now general consensus that the optimal blood glucose target for hospitalized patients is approximately 106-180 mg/dl (6-10 mmol/l). Recommendations for the management of antihyperglycemic medications vary among national guidelines. It may not be necessary to cease all antihyperglycemic agents prior to surgery. Sodium-glucose cotransporter 2 inhibitors (SGLT2i) are associated with higher rates of ketoacidosis especially in acutely unwell and postsurgical patients. The clinical practice implications of new insulin formulations, and new systems for insulin delivery, are not clear. The optimal perioperative management of these will vary depending on local institutional factors such as staff skills and existing clinical practices. Improved hospital care delivery standards, quality assurance, process improvements, consistency in clinical practice, and coordinated multidisciplinary teamwork should be a major focus for improving outcomes of perioperative patients with diabetes. SUMMARY: Sulfonylureas and SGLT2i should be ceased before moderate or major surgery. Other oral antihyperglycemic therapies may be continued or ceased. Complex patients and/or new therapies require specialized multidisciplinary management.

Indexed as

Administration, OralBlood GlucoseDiabetes MellitusHumansHypoglycemic AgentsInsulinPatient Care PlanningPatient Care TeamPerioperative CarePostoperative ComplicationsPractice Guidelines as TopicSurgical Procedures, OperativeBlood GlucoseHypoglycemic AgentsInsulin

Identifiers

PMID30958402
PMCPMC6522201
OpenAlexW2925674564

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.