ReviewInternational journal of molecular sciences2019
Platelet-Rich Fibrin Scaffolds for Cartilage and Tendon Regenerative Medicine: From Bench to Bedside.
Review in International journal of molecular sciences, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
37 citing papers in PubMed, 2 syntheses or guidelines pooled it, 76 citations in OpenAlex.
- Assessing the Impact of Stem Cell-based Therapy on Periodontal Health: A Meta-analysis of Clinical Studies.Current stem cell research & therapy · 2025Pooled it
- Platelet-rich plasma for pilonidal disease: a systematic review.The Journal of international medical research · 2023Pooled it
- A proof-of-concept study of an albumin-based bilayered scaffold for cartilage regeneration.Materials today. Bio · 2026Article
- Therapeutic Effect of Photobiomodulation and Single Intratendinous Injection at the Lesion Site of Platelet-Rich Fibrin in Inducted Tendinopathy.Journal of biophotonics · 2026Article
- Comparison of the effects of injectable platelet-rich fibrin and concentrated growth factor on tendon-bone interface healing in the rabbit rotator cuff tear model.Acta orthopaedica et traumatologica turcica · 2026Article
- Activated Platelet-Rich Plasma Fibrin Scaffolds Enhance Axonal Regeneration and Functional Recovery Following Spinal Cord Injury.Annals of biomedical engineering · 2026Article
- Concentrated growth factors: basic characteristics and clinical application.Open medicine (Warsaw, Poland) · 2026Review
- Beneficial Effect of Platelet-Rich Fibrin as an Adjunct to Nonsurgical Therapy After Subgingival Professional Mechanical Plaque Removal for Periodontitis: A Systematic Review and Meta-Analysis.Clinics and practice · 2025Review
- Exploring the Impact of Extraplatelet Content on Fibrin-Based Scaffold Performance for Regenerative Therapies.International journal of molecular sciences · 2025Article
- The Role of Injectable Platelet-Rich Fibrin in Orthopedics: Where Do We Stand?Current issues in molecular biology · 2025Review
- Tendon Tissue Engineering: Pathophysiological Mechanism and Bioengineering Therapy of Tendinopathy.International journal of nanomedicine · 2025Review
- Platelet-rich fibrin in the management of oral mucosal lesions: a scoping review.BMC oral health · 2024Article
- Effectiveness of Injectable Platelet-Rich Fibrin Therapy in Alopecia and Facial Rejuvenation: A Systematic Review.Cureus · 2024Review
- In Vitro Antimicrobial Properties and Their Mechanisms in Relation to Reactive Oxygen Species of Canine Platelet-Rich Fibrin.Animals : an open access journal from MDPI · 2023Article
- Hypoxia Preconditioned Serum (HPS) Promotes Proliferation and Chondrogenic Phenotype of Chondrocytes In Vitro.International journal of molecular sciences · 2023Article
- Osteochondral Regeneration Ability of Uncultured Bone Marrow Mononuclear Cells and Platelet-Rich Fibrin Scaffold.Bioengineering (Basel, Switzerland) · 2023Article
- Fibrin and Marine-Derived Agaroses for the Generation of Human Bioartificial Tissues: An Ex Vivo and In Vivo Study.Marine drugs · 2023Article
- Silver nanoparticles and platelet-rich fibrin accelerate tendon healing in donkey.Scientific reports · 2023Article
- Article
- Evolution and Clinical Advances of Platelet-Rich Fibrin in Musculoskeletal Regeneration.Bioengineering (Basel, Switzerland) · 2023Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 4 institutions in 1 country.
Funding
Abstract
Nowadays, research in Tissue Engineering and Regenerative Medicine is focusing on the identification of instructive scaffolds to address the requirements of both clinicians and patients to achieve prompt and adequate healing in case of injury. Among biomaterials, hemocomponents, and in particular Platelet-rich Fibrin matrices, have aroused widespread interest, acting as delivery platforms for growth factors, cytokines and immune/stem-like cells for immunomodulation; their autologous origin and ready availability are also noteworthy aspects, as safety- and cost-related factors and practical aspects make it possible to shorten surgical interventions. In fact, several authors have focused on the use of Platelet-rich Fibrin in cartilage and tendon tissue engineering, reporting an increasing number of in vitro, pre-clinical and clinical studies. This narrative review attempts to compare the relevant advances in the field, with particular reference being made to the regenerative role of platelet-derived growth factors, as well as the main pre-clinical and clinical research on Platelet-rich Fibrin in chondrogenesis and tenogenesis, thereby providing a basis for critical revision of the topic.
Indexed as
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What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.