ArticleMolecular genetics & genomic medicine2019
Prioritization and comprehensive analysis of genes related to major depressive disorder.
Article in Molecular genetics & genomic medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 16 citations in OpenAlex.
- Chronic administration of isotretinoin induces depressive- and anxiety-like behaviors by altering the neuroactive ligand-receptor interaction pathway in adolescent mice.Translational psychiatry · 2025Article
- Co-expression network of mRNA and DNA methylation in first-episode and drug-naive adolescents with major depressive disorder.Frontiers in psychiatry · 2023Article
- Biological, Psychological, and Social Determinants of Depression: A Review of Recent Literature.Brain sciences · 2021Review
- Perinatal SSRI Exposure Disrupts G Protein-coupled Receptor BAI3 in Developing Dentate Gyrus and Adult Emotional Behavior: Relevance to Psychiatric Disorders.Neuroscience · 2021Article
- PathCNN: interpretable convolutional neural networks for survival prediction and pathway analysis applied to glioblastoma.Bioinformatics (Oxford, England) · 2021Article
- Network Pharmacology and Molecular Docking Analyses of Mechanisms Underlying Effects of theEvidence-based complementary and alternative medicine : eCAM · 2021Article
- Analysis of Differentially Expressed Genes in the Dentate Gyrus and Anterior Cingulate Cortex in a Mouse Model of Depression.BioMed research international · 2021Article
- Therapeutic Targets and Mechanism of Xingpi Jieyu Decoction in Depression: A Network Pharmacology Study.Evidence-based complementary and alternative medicine : eCAM · 2021Article
- Metabolomic analysis of animal models of depression.Metabolic brain disease · 2020Article
- Associations Among Monoamine Neurotransmitter Pathways, Personality Traits, and Major Depressive Disorder.Frontiers in psychiatry · 2020Review
- Prioritization and comprehensive analysis of genes related to major depressive disorder.Molecular genetics & genomic medicine · 2019Article
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundMajor depressive disorder (MDD) is a serious mental health problem in modern society, which is difficult to identify and diagnose in the early stages. Despite strong evidence supporting the heritability of MDD, progresses in large-scale and individual genetic studies remain preliminary.
methodsIn this study, a multi-data source-based prioritization (MDSP) method was proposed, and an appropriate threshold was determined for the optimization of depression-related genes (DEPgenes). Analyses on Gene Ontology biological processes, KEGG pathway and the specific pathway crosstalk network were further proposed.
resultsA total of 143 DEPgenes were identified and the MDD-specific network was constructed for the pathogenesis investigation and therapeutic methods development of MDD. Comparing with existing research strategies, the genetic optimization and analysis results were confirmed to be reliable. Finally, the pathway enrichment and crosstalk analyses revealed two unique pathway interaction modules that were significantly enriched with MDD genes. The related core pathways of neuroactive ligand-receptor interaction and dopaminergic synapse supported the neuropathology hypothesis of MDD. And the pathways of serotonergic synapse and morphine addiction indicated the mechanism of drug addiction caused by serotonin used in the treatment.
conclusionsThis work provided a reference for the study of MDD, although future validation by extensive experimentation is still required.
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