ArticleMetabolic brain disease2019
Rutin alleviates cadmium-induced neurotoxicity in Wistar rats: involvement of modulation of nucleotide-degrading enzymes and monoamine oxidase.
Article in Metabolic brain disease, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed.
- Ameliorative effects of Crocin as a potent antioxidant with its spectral characterization against Cadmium chloride-induced hepatotoxicity.Scientific reports · 2026Article
- Biochemical and Molecular Effects of Rutin on Oxidative and Inflammatory Pathways in the Heart and Aorta of Diesel Exhaust Particles-Induced Toxicity in Male Rats.Cell biochemistry and biophysics · 2026Article
- Nutraceuticals: A strategy to mitigate neurotoxicity.Advances in neurotoxicology · 2026Article
- Neuroprotective effects of rutin, sodium selenite, and rutin-conjugated selenium nanoparticles in a social isolation model.Frontiers in pharmacology · 2026Article
- Mitigation of Acute Hepatotoxicity Induced by Cadmium Through Morin: Modulation of Oxidative and Pro-apoptotic Endoplasmic Reticulum Stress and Inflammatory Responses in Rats.Biological trace element research · 2024Article
- Effect of curcumin-donepezil combination on spatial memory, astrocyte activation, and cholinesterase expressions in brain of scopolamine-treated rats.Molecular biology reports · 2024Article
- Flavonols in Action: Targeting Oxidative Stress and Neuroinflammation in Major Depressive Disorder.International journal of molecular sciences · 2023Review
- The role of GRP78/ATF6/IRE1 and caspase-3/Bax/Bcl2 signaling pathways in the protective effects of gallic acid against cadmium-induced liver damage in rats.Iranian journal of basic medical sciences · 2023Article
- Curative Potential of Substances with Bioactive Properties to Alleviate Cd Toxicity: A Review.International journal of environmental research and public health · 2022Review
- Rutin Ameliorates Cadmium-Induced Necroptosis in the Chicken Liver via Inhibiting Oxidative Stress and MAPK/NF-κB Pathway.Biological trace element research · 2022Article
- Rutin via Increase in the CA3 Diameter of the Hippocampus Exerted Antidepressant-Like Effect in Mouse Model of Maternal Separation Stress: Possible Involvement of NMDA Receptors.Behavioural neurology · 2020Article
- Evaluating the effect of rutin on contrast-induced nephropathy in rats.Avicenna journal of phytomedicineArticle
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Rutin is a flavonoid commonly found in many vegetables, fruits and other plant species. Thus, this study investigated the protective role of rutin on cognitive function and impairment of ectonucleotidase, monoamine oxidase (MAO) and antioxidant enzymes activities in the cortex and hippocampus of cadmium-induced rats. Cognitive impairment was induced by an oral administration of 5 mg/kg Cadmium chloride for 14 consecutive days. Rutin was dissolved in 2% dimethyl sulfoxide (DMSO) and administered orally at the doses of 25 and 50 mg/kg for 14 days. Thereafter, animals were divided into six groups (n = 6) as follows: control, rutin 25 mg/kg, rutin 50 mg/kg, cadmium, cadmium plus rutin 25 mg/kg, cadmium plus rutin 50 mg/kg. After treatment period of 14 days, animals were sacrificed and the brain was dissected into cortex and hippocampus. Results showed that cadmium caused a significant increase in ectonucleotidases, adenosine deaminase (ADA) and MAO activities, with a concomitant decrease in thiol levels and antioxidant enzymes activities. However, treatment with rutin decreased ectonucleotidase, ADA and MAO activities in cadmium-induced rats. In addition, rutin reduced residual level of cadmium ion in the brain of cadmium-induced rats. Conclusively, present findings revealed that rutin could prevent/restored the impairment of the enzymes that regulate the purinergic and monoaminergic extracellular signaling and restore antioxidant status in cognitive impairment caused by prolonged cadmium exposure.
Indexed as
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30972687What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.