Evidence map›Paper›PMID 30974172›Full record

ArticleBrain, behavior, and immunity2019

Maternal pro-inflammatory state during pregnancy and newborn leukocyte telomere length: A prospective investigation.

Claudia Lazarides, Elissa S Epel, Jue Lin, Elizabeth H Blackburn, Manuel C Voelkle, Claudia Buss, Hyagriv N Simhan, Pathik D Wadhwa, Sonja Entringer

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Brain, behavior, and immunity, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed, 1 pooled it
3.8field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

29 citing papers in PubMed, 1 synthesis or guideline pooled it, 48 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 5 institutions in 2 countries.

Claudia LazaridesCharité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health (BIH), Institute of Psychological Medicine, Charitéplatz 1, 10117 Berlin, Germany.
Elissa S EpelDepartment of Psychiatry, University of California, San Francisco, CA, USA.
Jue LinDepartment of Biochemistry & Biophysics, University of California, San Francisco, CA, USA.
Elizabeth H BlackburnDepartment of Biochemistry & Biophysics, University of California, San Francisco, CA, USA.
Manuel C VoelkleDepartment of Psychology, Humboldt University, Berlin, Germany.
Claudia BussCharité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health (BIH), Institute of Psychological Medicine, Charitéplatz 1, 10117 Berlin, Germany; Department of Pediatrics, University of California, Irvine, CA 92617, USA; Development, Health and Disease Research Program, University of California, Irvine, CA 92617, USA.
Hyagriv N SimhanDepartment of Obstetrics, Gynecology and Reproductive Sciences, University of Pittsburgh, Pittsburgh, PA, USA.
Pathik D WadhwaDepartment of Psychiatry & Human Behavior, University of California, Irvine, CA 92617, USA; Department of Pediatrics, University of California, Irvine, CA 92617, USA; Department of Obstetrics & Gynecology, University of California, Irvine, CA 92617, USA; Department of Epidemiology, University of California, Irvine, CA 92617, USA; Development, Health and Disease Research Program, University of California, Irvine, CA 92617, USA. Electronic address: pwadhwa@uci.edu.
Sonja EntringerCharité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health (BIH), Institute of Psychological Medicine, Charitéplatz 1, 10117 Berlin, Germany; Department of Pediatrics, University of California, Irvine, CA 92617, USA; Development, Health and Disease Research Program, University of California, Irvine, CA 92617, USA. Electronic address: sonja.entringer@charite.de.
Humboldt-Universität zu Berlin · DEUniversity of California, San Francisco · USCharité - Universitätsmedizin Berlin · DEUniversity of California, Irvine · USUniversity of Pittsburgh · US

Funding

University of California Health Participation in the National COVID Cohort Collaborative (N3C)UL1TR001414 · NCATS · UNIVERSITY OF CALIFORNIA-IRVINE · PI COOPER, DAN M, VILAIN, ERIC J. · 2015 to 2023
$35.1M
Pre- and Postnatal Exposure Periods for Child Health: Common Risks and Shared MechanismsUG3OD023349 · OD · UNIVERSITY OF ROCHESTER · PI BARRETT, EMILY S, MILLER, RICHARD KERMIT · 2016 to 2024
$7.0M
Maternal Acculturation in Pregnancy and Infant Adiposity in Mexican AmericansR01MD010738 · NIMHD · UNIVERSITY OF CALIFORNIA-IRVINE · PI ENTRINGER, SONJA, WADHWA, PATHIK D · 2016 to 2020
$3.6M
EMA Assessment of Biobehavioral Processes in Human PregnancyR01HD060628 · NICHD · UNIVERSITY OF CALIFORNIA-IRVINE · PI WADHWA, PATHIK D · 2010 to 2014
$3.4M
Social Disadvantage and Fetal Programming of Newborn-Infant Telomere BiologyR01AG050455 · NIA · MAGEE-WOMEN'S RES INST AND FOUNDATION · PI EPEL, ELISSA S., SIMHAN, HYAGRIV N · 2016 to 2020
$3.0M
Prenatal stress biology, infant body composition and obesity riskR01HD065825 · NICHD · UNIVERSITY OF CALIFORNIA-IRVINE · PI ENTRINGER, SONJA, WADHWA, PATHIK D · 2010 to 2014
$2.2M
NCATS NIH HHS UL1 TR001414NIA NIH HHS R01 AG050455NICHD NIH HHS R01 HD060628NICHD NIH HHS R01 HD065825NIH HHS UG3 OD023349NIMHD NIH HHS R01 MD010738
6 · The paper itself

Abstract

introductionTelomere biology plays a fundamental role in maintaining the integrity of the genome and cell, and shortened telomeres have been linked to several age-related diseases. The initial (newborn) telomere length (TL) represents a critically important feature of the telomere biology system. Exposure to a variety of adverse prenatal conditions such as maternal stress, suboptimal diet, obesity, and obstetric complications, is associated with shorter offspring TL at birth and in adult life. Many, if not all, of these exposures are believed to have an inflammatory component. In this context, stress-related immunological processes during pregnancy may constitute a potential additional biological pathway because they can affect telomere length and telomerase activity via transcriptions factors such as cyclic adenosine monophosphate-dependent transcription factor (ATF7) and nuclear factor-kappa B (NF-κB). Thus, in the present study we examined the hypothesis that maternal pro-inflammatory state across pregnancy, operationalized as the balance between tumor necrosis factor (TNF)-α, a major pro-inflammatory cytokine, and interleukin-10 (IL-10), the major anti-inflammatory cytokine, is associated with newborn leukocyte telomere length (LTL) at birth. METHODS AND MATERIALS: Participants were healthy women (N = 112) recruited in early pregnancy. Concentrations of TNF- α and IL-10 were quantified in early, mid and late pregnancy from maternal blood samples. Telomere length was assessed in newborn blood samples soon after birth.

resultsAfter adjusting for maternal age, maternal pre-pregnancy BMI, birth weight percentile, and infant sex, a higher mean TNF-α/IL-10 ratio across pregnancy was significantly associated with shorter newborn TL (β = -.205, p = .030). Newborn TL was, on average, 10% shorter in offspring of women in the upper compared to lower quartile of the TNF-α/IL-10 ratio during pregnancy. DISCUSSION: These findings provide new evidence in humans for a potential "programming" mechanism linking maternal systemic pro-inflammatory processes during pregnancy with the initial (newborn) setting of her offspring's telomere system.

Indexed as

AdultFemaleHumansInfant, NewbornInflammationInterleukin-10LeukocytesLongitudinal StudiesPregnancyPregnancy ComplicationsProspective StudiesTelomereTumor Necrosis Factor-alphaYoung AdultIL10 protein, humanInterleukin-10TNF protein, humanTumor Necrosis Factor-alphaCytokinesDevelopmental programmingDisease susceptibilityPregnancyPro-inflammatory ratioTelomeres

Identifiers

PMID30974172
PMCPMC7954441
OpenAlexW2939443423

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.