Other lipid agents × cardiovascular events

SynthesisJAMA network open2019

Assessment of the Role of Niacin in Managing Cardiovascular Disease Outcomes: A Systematic Review and Meta-analysis.

Elvira D'Andrea et al.PubMed ↗Full text ↗Publisher ↗

What the trial testedrandomised · 760 people · 2019

Randomised comparison

Probably reduced cardiovascular events

−26%−42% to −4%

Bigger than 6 in 10 for cardiovascular events

As reported

RR 0.74, 95% CI 0.58–0.96

What moved togetherboth groups pooled, not the treatment’s effect

Correlation, not cause

Went with fewer cardiovascular events

−26%−41% to −6%

Bigger than 6 in 10 for cardiovascular events

As reported

RR 0.74, 95% CI 0.59–0.94

Correlation, not cause

Went with fewer cardiovascular events

−26%−42% to −4%

Bigger than 6 in 10 for cardiovascular events

As reported

RR 0.74, 95% CI 0.58–0.96

Correlation, not cause

Went with fewer cardiovascular events

−49%−63% to −28%

Bigger than 9 in 10 for cardiovascular events

As reported

RR 0.51, 95% CI 0.37–0.72

+4 more in the walkthrough ↓

Eight numbers in the abstract

the abstract, start to end

(acute coronary syndrome: relative risk, 0.74; 95% CI, 0.58-0.96; stroke: relative risk, 0.74; 95% CI, 0.59-0.94; revascularization: relative risk, 0.51; 95% CI, 0.37-0.72).

of niacin with CVD mortality (RR, 0.98; 95% CI, 0.90-1.07) or coronary

of niacin treatment with stroke (RR, 0.95; 95% CI, 0.85-1.06), acute

a 26% reduction in stroke events (RR, 0.74; 95% CI, 0.59-0.94) in the

was associated with reduced risk (RR, 0.79; 95% CI, 0.64-0.98) for both

associated with a 26% lower rate (RR, 0.74; 95% CI, 0.58-0.96) compared

← favours treatmentfavours comparator →
could be chance
Cardiovascular events
RR 0.740.59–0.94
Cardiovascular events
RR 0.740.58–0.96
Cardiovascular events
RR 0.510.37–0.72
All-cause mortality
RR 0.980.90–1.07
Cardiovascular events
RR 0.950.85–1.06
Cardiovascular events
RR 0.740.59–0.94
Cardiovascular events
RR 0.790.64–0.98
Cardiovascular events
RR 0.740.58–0.96
Other lipid agentsCardiovascular eventsAll-cause mortality
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Full record →Abstract, authors, funding and every citing paper · PMID 30977858