ArticleJournal of clinical medicine2019
Cardiac and Peripheral Autonomic Responses to Orthostatic Stress During Transcutaneous Vagus Nerve Stimulation in Healthy Subjects.
Article in Journal of clinical medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Cardiovascular effects of auricular stimulation -a systematic review and meta-analysis of randomized controlled clinical trials.Frontiers in neuroscience · 2023Pooled it
- Auricular Vagus Neuromodulation-A Systematic Review on Quality of Evidence and Clinical Effects.Frontiers in neuroscience · 2021Pooled it
- Acute Effects of Transcutaneous Tibial Nerve Stimulation on Autonomic Nervous System Activity in Healthy Volunteers: An Exploratory Study.Neurourology and urodynamics · 2026Article
- Short and long term effects of a two-week transcutaneous vagus nerve stimulation in hyperadrenergic postural orthostatic tachycardia syndrome: a proof-of-concept trial.European journal of internal medicine · 2026Article
- Transcutaneous auricular vagus nerve stimulation in healthy individuals, stroke, and Parkinson's disease: a narrative review of safety, parameters, and efficacy.Frontiers in physiology · 2025Review
- Effect of transcutaneous auricular vagus nerve stimulation on stress regulation: an EEG and questionnaire study.Frontiers in digital health · 2025Article
- Low-level auricular vagus nerve stimulation lowers blood pressure and heart rate in paroxysmal atrial fibrillation patients: a self-controlled study.Frontiers in neuroscience · 2025Article
- The Intestine in Acute and Long COVID: Pathophysiological Insights and Key Lessons.The Yale journal of biology and medicine · 2024Review
- Article
- Transcutaneous auricular vagus nerve stimulation would be an alternative to implantable cervical vagus nerve stimulation in some situation.Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan · 2023Article
- Management of auricular transcutaneous neuromodulation and electro-acupuncture of the vagus nerve for chronic migraine: a systematic review.Frontiers in neuroscience · 2023Review
- Dysautonomia following breast surgery: Disproportionate response to postoperative hematoma.Surgery open science · 2022Article
- "The Wandering Nerve Linking Heart and Mind" - The Complementary Role of Transcutaneous Vagus Nerve Stimulation in Modulating Neuro-Cardiovascular and Cognitive Performance.Frontiers in neuroscience · 2022Review
- Transdermal auricular vagus stimulation for the treatment of postural tachycardia syndrome.Autonomic neuroscience : basic & clinical · 2021Article
- Targeting the Autonomic Nervous System for Risk Stratification, Outcome Prediction and Neuromodulation in Ischemic Stroke.International journal of molecular sciences · 2021Review
- Autonomic Nervous System: From Bench to Bedside.Journal of clinical medicine · 2020Article
- International Consensus Based Review and Recommendations for Minimum Reporting Standards in Research on Transcutaneous Vagus Nerve Stimulation (Version 2020).Frontiers in human neuroscience · 2020Review
- Autonomic Control of the Heart and Its Clinical Impact. A Personal Perspective.Frontiers in physiology · 2020Article
- The Instant Effects of Continuous Transcutaneous Auricular Vagus Nerve Stimulation at Acupoints on the Functional Connectivity of Amygdala in Migraine without Aura: A Preliminary Study.Neural plasticity · 2020Article
- Evaluation of Fatigue in Cancer Patients in An Area Affected by The Great East Japan Earthquake.Asia-Pacific journal of oncology nursingArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Previous studies showed that transcutaneous vagus nerve stimulation (tVNS) modulates the autonomic nervous system (ANS) in resting condition. However, the autonomic regulation in response to an orthostatic challenge during tVNS in healthy subjects remains unknown. We tested the hypothesis that tVNS reduces heart rate (HR) and alters the responsivity of ANS to orthostatic stress in healthy subjects. In a randomized and cross-over trial, thirteen healthy subjects underwent two experimental sessions on different days: (1) tVNS and (2) control. Using a tVNS device, an auricular electrode was placed on the left
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.