ArticleFrontiers in cell and developmental biology2019
Avian Primordial Germ Cells Contribute to and Interact With the Extracellular Matrix During Early Migration.
Article in Frontiers in cell and developmental biology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 32 citations in OpenAlex.
- Review
- Transcriptional Profiling of Primordial Germ Cells During Chicken Embryonic Development.Veterinary sciences · 2026Article
- Generation of chimeric chickens resistant to infection by avian leukemia virus subgroups A, B, D, E, and K through primordial germ cells.Poultry science · 2026Article
- Manipulating primordial germ cells from chicken and other bird species.The Journal of reproduction and development · 2026Review
- Article
- A collagenous extracellular matrix regulates germline gene expression in the sea star embryo.Scientific reports · 2025Article
- The journey of a generation: advances and promises in the study of primordial germ cell migration.Development (Cambridge, England) · 2024Article
- Matrisome AnalyzeR - a suite of tools to annotate and quantify ECM molecules in big datasets across organisms.Journal of cell science · 2023Article
- Extracellular Matrix Dynamics as an Emerging yet Understudied Hallmark of Aging and Longevity.Aging and disease · 2023Review
- Gonad Ontogeny and Sex Differentiation in a Poeciliid,Biology · 2023Article
- Matrisome AnalyzeR: A suite of tools to annotate and quantify ECM molecules in big datasets across organisms.bioRxiv : the preprint server for biology · 2023Article
- Review
- Finer resolution analysis of transcriptional programming during the active migration of chicken primordial germ cells.Computational and structural biotechnology journal · 2022Article
- A Novel Egg-In-Cube System Enables Long-Term Culture and Dynamic Imaging of Early Embryonic Development.Frontiers in physiology · 2022Article
- Protein expression reveals a molecular sexual identity of avian primordial germ cells at pre-gonadal stages.Scientific reports · 2021Article
- Single-Cell RNA Sequencing Revealed the Heterogeneity of Gonadal Primordial Germ Cells in Zebra Finch (Frontiers in cell and developmental biology · 2021Article
- Extracellular matrix dynamics in tubulogenesis.Cellular signalling · 2020Review
- The quail genome: insights into social behaviour, seasonal biology and infectious disease response.BMC biology · 2020Article
- Effect of autologous NK cell immunotherapy on advanced lung adenocarcinoma with EGFR mutations.Precision clinical medicine · 2019Article
Corrections and comments
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Authors and funding
9 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
During early avian development, primordial germ cells (PGC) are highly migratory, moving from the central area pellucida of the blastoderm to the anterior extra-embryonic germinal crescent. The PGCs soon move into the forming blood vessels by intravasation and travel in the circulatory system to the genital ridges where they participate in the organogenesis of the gonads. This complex cellular migration takes place in close association with a nascent extracellular matrix that matures in a precise spatio-temporal pattern. We first compiled a list of quail matrisome genes by bioinformatic screening of human matrisome orthologs. Next, we used single cell RNA-seq analysis (scRNAseq) to determine that PGCs express numerous ECM and ECM-associated genes in early embryos. The expression of select ECM transcripts and proteins in PGCs were verified by fluorescent
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.