Evidence map›Paper›PMID 30987200›Full record

SynthesisNutrients2019

A Review of

Ángela Hernández-Ruiz, Belén García-Villanova, Eduardo Guerra-Hernández, Pilar Amiano, Miguel Ruiz-Canela, Esther Molina-Montes

Abstract readSystematic Review
In one paragraph

Synthesis in Nutrients, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 128 papers.

0numbers the graph read from it
0cells of the map it votes in
128citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

128 citing papers in PubMed.

  1. Trial
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  8. Review
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  12. Article
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  14. Biomolecules · 2026
    Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Article

68 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Ángela Hernández-RuizDepartment of Nutrition and Bromatology, Faculty of Pharmacy, University of Granada, 18071 Granada, Spain. angelahernruiz@correo.ugr.es.
Belén García-VillanovaDepartment of Nutrition and Bromatology, Faculty of Pharmacy, University of Granada, 18071 Granada, Spain. belenv@ugr.es.
Eduardo Guerra-HernándezDepartment of Nutrition and Bromatology, Faculty of Pharmacy, University of Granada, 18071 Granada, Spain. ejguerra@ugr.es.
Pilar AmianoPublic Health Division of Gipuzkoa, Biodonostia Research Institute, Health Department, 20014 San Sebastian, Spain. epicss-san@euskadi.eus.
Miguel Ruiz-CanelaDepartment of Preventive Medicine and Public Health, University of Navarra, 31003 Pamplona, Spain. mcanela@unav.es.ORCID 0000-0002-7684-2787
Esther Molina-MontesGenetic and Molecular Epidemiology Group, Spanish National Cancer Research Centre (CNIO), 28029 Madrid, Spain. memolina@cnio.es.

Funding

Instituto de Salud Carlos III PI12/00002
6 · The paper itself

Abstract

Oxidative Balance Scores (OBSs) are tools that have emerged to evaluate the global balance of individuals' oxidation-reduction status. The aim was to compare OBSs available in the literature regarding their characteristics and associations with chronic diseases in epidemiological studies. Studies that developed OBSs were searched in PubMed until August 2018. A total of 21 OBSs were identified. These OBSs presented different scoring schemes and different types of anti- and pro-oxidant components, including dietary factors (dietary intake and/or nutrient biomarkers), lifestyle factors, and medications. Most OBSs were based on over 10 components, and some included only dietary factors. Few considered weighted components in the score. Only three OBSs were validated as potential surrogates of oxidative balance through inflammation and OS-related biomarkers. Notably, all the OBSs were associated-to a varying degree-with a reduced risk of cardiovascular diseases, chronic kidney disease, colorectal adenomas, and different cancer types (colorectal and breast cancer), as well as with all-cause and cancer-related mortality. For other outcomes, e.g., prostate cancer, contradictory results were reported. In summary, there is a great heterogeneity in the definition of OBSs. Most studies are concordant in supporting that excessive OS reflected by a lower OBS has deleterious effects on health. Unified criteria for defining the proper OBSs, valuable to gauge OS-related aspects of the diet and lifestyle that may lead to adverse health outcomes, are needed.

Indexed as

Healthy LifestyleOxidative StressAdultAgedAlcohol DrinkingAntioxidantsDiet, HealthyDisease SusceptibilityExerciseFemaleHealth StatusHumansInflammation MediatorsMaleMiddle AgedOxidation-ReductionAntioxidantsInflammation MediatorsReactive Oxygen Speciesantioxidantshealthy diethealthy lifestyleoxidative stressreview

Identifiers

PMID30987200
PMCPMC6520884

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.