ArticleArchives of toxicology2019
Toxicological assessment of magnesium oxide nanoparticles in HT29 intestinal cells.
Article in Archives of toxicology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
9 citing papers in PubMed, 29 citations in OpenAlex.
- Pentatropis Capensis as a Novel Bioresource for Selenium Nanoparticle Synthesis: Insights into Biocompatibility, Cytotoxicity and in Vitro Toxicity Test on Zebrafish.Applied biochemistry and biotechnology · 2026Article
- Effect of Calcination Temperatures on Crystallite Size, Particle Size, and Antimicrobial Activity of Synthesized MgO and Its Cytotoxicity.International journal of molecular sciences · 2025Article
- Assessment of the bioactivity of bioinspired magnesium oxide nanoparticles from theFrontiers in bioengineering and biotechnology · 2024Article
- Armoring of MgO by a Passivation Layer Impedes Direct Air Capture of COEnvironmental science & technology · 2023Article
- Metal Oxide Nanoparticles in Food Packaging and Their Influence on Human Health.Foods (Basel, Switzerland) · 2023Review
- Magnetic, Optical and Phonon Properties of Ion-Doped MgO Nanoparticles. Application for Magnetic Hyperthermia.Materials (Basel, Switzerland) · 2023Article
- The mechanistic effects of human digestion on magnesium oxide nanoparticles: implications for probiotics Lacticaseibacillus rhamnosus GG and Bifidobacterium bifidum VPI 1124.Environmental science. Nano · 2022Article
- Oxaliplatin induces ferroptosis and oxidative stress in HT29 colorectal cancer cells by inhibiting the Nrf2 signaling pathway.Experimental and therapeutic medicine · 2022Article
- Establishment of a standardized dietary model for nanoparticles oral exposure studies.Food science & nutrition · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Nanoparticles (NPs) are increasingly used in different consumer-related areas, for instance in food packaging or as additives, because of their enormous potential. Magnesium oxide (MgO) is an EU-approved food additive (E number 530). It is commonly used as a drying agent for powdered foods, for colour retention or as a food supplement. There are no consistent results regarding the effects of oral MgO NP uptake. Consequently, the aim of this study was to examine the effects of MgO NPs in the HT29 intestinal cell line. MgO NP concentrations ranged from 0.001 to 100 μg/ml and incubation times were up to 24 h. The cytotoxic and genotoxic potential were investigated. Apoptotic processes and cell cycle changes were analysed by flow cytometry. Finally, oxidative stress was examined. Transmission electron microscopy indicated that there was no cellular uptake. MgO NPs had no cytotoxic or genotoxic effects in HT29 cells and they did not induce apoptotic processes, cell cycle changes or oxidative stress.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.