Evidence map›Paper›PMID 30990108›Full record

ArticleMolecular pain

ET

Xiaoli Zheng, Yan Tai, Dongwei He, Boyu Liu, Chuan Wang, Xiaomei Shao, Sven-Eric Jordt, Boyi Liu

Open access · goldAbstract read
In one paragraph

Article in Molecular pain. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
1.9field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 21 citations in OpenAlex.

  1. Article
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  7. Article
  8. Article
  9. Review
  10. Oxaliplatin Depolarizes the IB4Frontiers in molecular neuroscience · 2021
    Article
  11. Article
  12. Article
  13. Article
  14. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 2 countries.

Xiaoli Zheng1 Department of Neurobiology and Acupuncture Research, The Third Clinical Medical College, Zhejiang Chinese Medical University, Key Laboratory of Acupuncture and Neurology of Zhejiang Province, Hangzhou, China.
Yan Tai2 Academy of Chinese Medical Sciences, Zhejiang Chinese Medical University, Hangzhou, China.
Dongwei He3 Department of Immune-Oncology, The Fourth Hospital of Hebei Medical University, Shijiazhuang, China.
Boyu Liu1 Department of Neurobiology and Acupuncture Research, The Third Clinical Medical College, Zhejiang Chinese Medical University, Key Laboratory of Acupuncture and Neurology of Zhejiang Province, Hangzhou, China.
Chuan Wang4 Department of Pharmacology, Hebei Medical University, Shijiazhuang, China.
Xiaomei Shao1 Department of Neurobiology and Acupuncture Research, The Third Clinical Medical College, Zhejiang Chinese Medical University, Key Laboratory of Acupuncture and Neurology of Zhejiang Province, Hangzhou, China.
Sven-Eric Jordt5 Department of Anesthesiology, Duke University School of Medicine, Durham, NC, USA.
Boyi Liu1 Department of Neurobiology and Acupuncture Research, The Third Clinical Medical College, Zhejiang Chinese Medical University, Key Laboratory of Acupuncture and Neurology of Zhejiang Province, Hangzhou, China.ORCID 0000-0001-9870-4548
The Third Affiliated Hospital of Zhejiang Chinese Medical University · CNHebei Medical University · CNDuke University · USZhejiang Chinese Medical University · CN

Funding

Mechanisms of Itch in Poison Ivy-Induced Allergic Contact DermatitisR21AR070554 · NIAMS · DUKE UNIVERSITY · PI JORDT, SVEN-ERIC · 2016 to 2017
$385k
NIAMS NIH HHS R21 AR070554
6 · The paper itself

Abstract

Endothelin-1 (ET-1) is a potent endogenous vasoconstrictor that has been widely known as a pain mediator involved in various pain states. Evidence indicates that ET-1 sensitizes transient receptor potential cation channel, subfamily A, member 1 (TRPA1) in vivo. But the molecular mechanisms still remain unknown. We aim to explore whether ET-1 sensitizes TRPA1 in primary sensory neurons and the molecular mechanisms. Ca

Indexed as

Signal TransductionAnimalsCyclic AMP-Dependent Protein KinasesEndothelin-1Ganglia, SpinalHEK293 CellsHumansHydrogen PeroxideHyperalgesiaMaleMice, Inbred C57BLReceptor, Endothelin ASensory Receptor CellsTRPA1 Cation ChannelCyclic AMP-Dependent Protein KinasesEndothelin-1Hydrogen PeroxideReceptor, Endothelin ATRPA1 Cation Channelendothelinpainprotein kinase AsensitizationTRPA1

Identifiers

PMID30990108
PMCPMC6537062
OpenAlexW2940147695

What Socratic holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.