Evidence map›Paper›PMID 31002708›Full record

SynthesisPloS one2019

Risk factors for gestational diabetes: An umbrella review of meta-analyses of observational studies.

Konstantinos Giannakou, Evangelos Evangelou, Panayiotis Yiallouros, Costas A Christophi, Nicos Middleton, Evgenia Papatheodorou, Stefania I Papatheodorou

Open access · goldAbstract readSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in PloS one, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 92 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
92citing papers in PubMed, 3 pooled it
17.3field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

92 citing papers in PubMed, 3 syntheses or guidelines pooled it, 185 citations in OpenAlex.

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32 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 4 countries.

Konstantinos GiannakouCyprus International Institute for Environmental & Public Health, Cyprus University of Technology, Limassol, Cyprus.ORCID 0000-0002-2185-561X
Evangelos EvangelouDepartment of Hygiene and Epidemiology, University of Ioannina, School of Medicine, University Campus, Ioannina, Greece.
Panayiotis YiallourosMedical School, University of Cyprus, Nicosia, Cyprus.
Costas A ChristophiCyprus International Institute for Environmental & Public Health, Cyprus University of Technology, Limassol, Cyprus.
Nicos MiddletonDepartment of Nursing, School of Health Sciences, Cyprus University of Technology, Limassol, Cyprus.
Evgenia Papatheodorou"Kentro Iatrikis Ioanninon", Ioannina, Greece.
Stefania I PapatheodorouCyprus International Institute for Environmental & Public Health, Cyprus University of Technology, Limassol, Cyprus.
Cyprus University of Technology · CYUniversity of Ioannina · GRHarvard University · USUniversity of Cyprus · CY

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BACKGROUND/

objectiveGestational diabetes mellitus (GDM) is a common pregnancy complication, with complex disease mechanisms, and several risk factors may contribute to its onset. We performed an umbrella review to summarize the evidence from meta-analyses of observational studies on risk factors associated with GDM, evaluate whether there are indications of biases in this literature and identify which of the previously reported associations are supported by convincing evidence.

methodsWe searched PubMed and ISI Web of Science from inception to December 2018 to identify meta-analyses examining associations between putative risk factors for GDM. For each meta-analysis we estimated the summary effect size, the 95% confidence interval, the 95% prediction interval, the between-study heterogeneity, evidence of small-study effects, and evidence of excess-significance bias.

resultsThirty eligible meta-analyses were identified, providing data on 61 associations. Fifty (82%) associations had nominally statistically significant findings (P<0.05), while only 15 (25%) were significant at P<10-6 under the random-effects model. Only four risk factors presented convincing evidence:, low vs. normal BMI (cohort studies), BMI ~30-35 kg/m2 vs. normal BMI, BMI >35 kg/m2 vs. normal BMI, and hypothyroidism.

conclusionsThe compilation of results from synthesis of observational studies suggests that increased BMI and hypothyroidism show the strongest consistent evidence for an association with GDM. Diet and lifestyle modifications in pregnancy should be tested in large randomized trials. Our findings suggest that women with known thyroid disease may be offered screening for GDM earlier in pregnancy.

Indexed as

Body Mass IndexDiabetes, GestationalFemaleHumansHypothyroidismMeta-Analysis as TopicObservational Studies as TopicPregnancyRandomized Controlled Trials as TopicRisk Factors

Identifiers

PMID31002708
PMCPMC6474596
OpenAlexW2937814568

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.