Evidence map›Paper›PMID 31003921›Full record

Trial reportJournal of diabetes and its complications2019

Serum uromodulin inversely associates with aortic stiffness in youth with type 1 diabetes: A brief report from EMERALD study.

Pattara Wiromrat, Petter Bjornstad, Carlos Roncal, Melanie Cree-Green, Amy Baumgartner, Gregory Coe, Yesenia Garcia Reyes, Michal Schäfer, Uyen Truong, Laura Pyle and 2 more

Open access · greenAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Journal of diabetes and its complications, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.8field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 8 citations in OpenAlex.

  1. Review
  2. Article
  3. Uromodulin biology.Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association · 2024
    Review
  4. Review
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 2 institutions in 1 country.

Pattara WiromratDepartment of Pediatric Endocrinology, University of Colorado School of Medicine, Aurora, CO, United States.
Petter BjornstadDepartment of Pediatric Endocrinology, University of Colorado School of Medicine, Aurora, CO, United States; Barbara Davis Center for Childhood Diabetes, University of Colorado Denver, Aurora, CO, United States.
Carlos RoncalDepartment of Nephrology, University of Colorado School of Medicine, Aurora, CO, United States.
Melanie Cree-GreenDepartment of Pediatric Endocrinology, University of Colorado School of Medicine, Aurora, CO, United States; Center for Women's Health Research, Divisions of General Internal Medicine and Cardiology, University of Colorado School of Medicine, Aurora, CO, United States.
Amy BaumgartnerDepartment of Pediatric Endocrinology, University of Colorado School of Medicine, Aurora, CO, United States.
Gregory CoeDepartment of Pediatric Endocrinology, University of Colorado School of Medicine, Aurora, CO, United States.
Yesenia Garcia ReyesDepartment of Pediatric Endocrinology, University of Colorado School of Medicine, Aurora, CO, United States.
Michal SchäferDivision of Pediatric Cardiology, University of Colorado School of Medicine, Aurora, CO, United States.
Uyen TruongDivision of Pediatric Cardiology, University of Colorado School of Medicine, Aurora, CO, United States.
Laura PyleDepartment of Pediatric Endocrinology, University of Colorado School of Medicine, Aurora, CO, United States.
Richard J JohnsonDepartment of Nephrology, University of Colorado School of Medicine, Aurora, CO, United States.
Kristen J NadeauDepartment of Pediatric Endocrinology, University of Colorado School of Medicine, Aurora, CO, United States; Barbara Davis Center for Childhood Diabetes, University of Colorado Denver, Aurora, CO, United States. Electronic address: kristen.nadeau@childrenscolorado.org.
University of Colorado Denver · USChildren's Hospital Colorado · US

Funding

Insulin Control of Fat Regulation and Exercise in TeensK23RR020038 · UNIVERSITY OF COLORADO DENVER · 2004 to 2005
$263k
The Next Generation of Innovative Cardiovascular Clinical/Translational ResearchersK24HL145076 · NHLBI · UNIVERSITY OF COLORADO DENVER · PI KRISTEN Jane NADEAU · 2022 to 2023
$230k
NCATS NIH HHS UL1 TR001082NCRR NIH HHS K23 RR020038NHLBI NIH HHS K24 HL145076NICHD NIH HHS K12 HD057022NIDDK NIH HHS K23 DK107871NIDDK NIH HHS K23 DK116720NIDDK NIH HHS R56 DK088971
6 · The paper itself

Abstract

Youth with type 1 diabetes (T1D) carry greater cardiovascular disease (CVD) risk than their nondiabetic peers. Low serum uromodulin (SUMOD) associates with increased CVD mortality in adults. We found that T1D youth have low SUMOD. Lower SUMOD correlated with aortic stiffness, suggesting its potential as a CVD biomarker in T1D.

Indexed as

Diabetes Mellitus, Type 1Vascular StiffnessAdolescentAdultAortaBiomarkersCardiovascular DiseasesChildDiabetic AngiopathiesFemaleGlomerular Filtration RateHumansMaleMetforminPulse Wave AnalysisRisk FactorsBiomarkersMetforminUromodulinAdolescentsAortic stiffnessAscending aortic pulse wave velocityRelative area changeSerum uromodulinType 1 diabetes

Identifiers

PMID31003921
PMCPMC6908304
OpenAlexW2922739317

What Socratic holds

Texttitle and abstract
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.