Evidence map›Paper›PMID 31015291›Full record

ArticleScience signaling2019

Proximity biotinylation identifies a set of conformation-specific interactions between Merlin and cell junction proteins.

Robert F Hennigan, Jonathan S Fletcher, Steven Guard, Nancy Ratner

Open access · greenAbstract read
In one paragraph

Article in Science signaling, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.2field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 25 citations in OpenAlex.

  1. Identification of PKN2 and MOB4 as Coordinators of Collective Cell Migration.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Article
  2. Article
  3. MerlinNature communications · 2024
    Article
  4. HPV18 E7 inhibits LATS1 kinase and activates YAP1 by degrading PTPN14.bioRxiv : the preprint server for biology · 2024
    Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Review
  10. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Robert F HenniganDivision of Experimental Hematology and Cancer Biology, Cincinnati Children's Hospital, Cincinnati, OH 45229, USA. robert.hennigan@cchmc.org.ORCID 0000-0002-7054-8384
Jonathan S FletcherDivision of Experimental Hematology and Cancer Biology, Cincinnati Children's Hospital, Cincinnati, OH 45229, USA.ORCID 0000-0001-7301-7549
Steven GuardDepartment of Molecular, Cellular & Developmental Biology, University of Colorado Boulder, Boulder, CO 80309, USA.
Nancy RatnerDivision of Experimental Hematology and Cancer Biology, Cincinnati Children's Hospital, Cincinnati, OH 45229, USA.
Cincinnati Children's Hospital Medical Center · USUniversity of Colorado Boulder · US

Funding

Medical Scientist Training ProgramT32GM063483 · NIGMS · UNIVERSITY OF CINCINNATI · PI KHURANA HERSHEY, GURJIT K. · 2002 to 2022
$6.7M
Ras Proteins in Nerve TumorigensisR37NS083580 · NINDS · CINCINNATI CHILDRENS HOSP MED CTR · PI RATNER, NANCY · 2014 to 2020
$2.7M
NIGMS NIH HHS T32 GM063483NINDS NIH HHS R37 NS083580
6 · The paper itself

Abstract

Neurofibromatosis type 2 is an inherited, neoplastic disease associated with schwannomas, meningiomas, and ependymomas and that is caused by inactivation of the tumor suppressor gene

Indexed as

Mechanotransduction, CellularAnimalsApoptosis Regulatory ProteinsBiotinylationCell Line, TransformedHumansIntercellular JunctionsMiceNeurofibromatosis 2Phosphatidylinositol 4,5-DiphosphateProtein DomainsSchwann CellsTumor Suppressor ProteinsApoptosis Regulatory ProteinsPhosphatidylinositol 4,5-DiphosphateTP53BP2 protein, humanTrp53bp2 protein, mouseTumor Suppressor Proteins

Identifiers

PMID31015291
PMCPMC6631321
OpenAlexW2940877739

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.