Evidence map›Paper›PMID 31019730›Full record

ArticleObesity science & practice2019

Effect of liraglutide on anthropometric measurements, sagittal abdominal diameter and adiponectin levels in people with type 2 diabetes treated with multiple daily insulin injections: evaluations from a randomized trial (MDI-liraglutide study 5).

S S Ahmadi, K Filipsson, H Dimenäs, S S Isaksson, H Imberg, S Sjöberg, B Ahrén, S Dahlqvist, T Gustafsson, J Tuomilehto and 2 more

Open access · goldAbstract read
In one paragraph

Article in Obesity science & practice, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 2 pooled it
1.1field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 2 syntheses or guidelines pooled it, 13 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Efficacy and Safety of a Biosimilar Liraglutide (MelitideDiabetes therapy : research, treatment and education of diabetes and related disorders · 2023
    Article
  4. Article
  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 8 institutions in 5 countries.

S S AhmadiDepartment of Molecular and Clinical Medicine University of Gothenburg Gothenburg Sweden.
K FilipssonDepartment of Clinical Sciences Lund Lund University Lund Sweden.
H DimenäsDepartment of Medicine South Älvsborg Hospital Borås Sweden.
S S IsakssonDepartment of Molecular and Clinical Medicine University of Gothenburg Gothenburg Sweden.
H ImbergDepartment of Mathematical Sciences Chalmers University of Technology and the University of Gothenburg Gothenburg Sweden.ORCID https://orcid.org/0000-0001-9447-663X
S SjöbergDepartment of Medicine, Karolinska Institute Karolinska University Hospital Huddinge Stockholm Sweden.
B AhrénDepartment of Clinical Sciences Lund Lund University Lund Sweden.ORCID https://orcid.org/0000-0002-9804-5340
S DahlqvistDepartment of Medicine NU Hospital Group Uddevalla Sweden.
T GustafssonDepartment of Clinical Chemistry Karolinska University Hospital Stockholm Sweden.
J TuomilehtoCentre for Vascular Prevention Danube University Krems Austria.
I B HirschDivision of metabolism, Endocrinology, and Nutrition University of Washington Seattle Washington USA.
M LindDepartment of Molecular and Clinical Medicine University of Gothenburg Gothenburg Sweden.ORCID https://orcid.org/0000-0002-3796-9283
NU Hospital Group · SEKarolinska University Hospital · SELund University · SESödra Älvsborg Hospital · SEStatisticon (Sweden) · SEUniversität für Weiterbildung Krems · ATUniversity of Gothenburg · SEUniversity of Washington · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

aimUse of the glucagon-like peptide 1 receptor agonist liraglutide has been shown to reduce weight. Different types of anthropometric measurements can be used to measure adiposity. This study evaluated the effect of liraglutide on sagittal abdominal diameter, waist circumference, waist-to-hip ratio and adiponectin levels in people with type 2 diabetes (T2D) treated with multiple daily insulin injections (MDI). MATERIALS AND

methodsIn the multicentre, double-blind, placebo-controlled MDI-liraglutide trial, 124 individuals with T2D treated with MDI were randomized to either liraglutide or placebo. Basal values of weight, waist circumference, waist-to-hip ratio, sagittal abdominal diameter and adiponectin were compared with measurements at 12 and 24 weeks after randomization.

resultsBaseline-adjusted mean weight loss was 3.8 ± 2.9 kg greater in liraglutide than placebo-treated individuals (

conclusionsIn patients with T2D, adding liraglutide to MDI may reduce abdominal and hip obesity to a similar extent, suggesting an effect on both visceral and subcutaneous fat. Liraglutide had greater effects on reducing abdominal obesity in patients with less pronounced long-term hyperglycaemia but did not affect adiponectin levels.

Indexed as

Adiponectinanthropometric measurementsliraglutidepredictive variable

Identifiers

PMID31019730
PMCPMC6469338
OpenAlexW2906141776

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.