Evidence map›Paper›PMID 31023762›Full record

Trial reportBMJ open2019

Lipoprotein(a) plasma levels, bone mineral density and risk of hip fracture: a post hoc analysis of the Women's Health Initiative, USA.

Bernhard Haring, Carolyn J Crandall, Laura Carbone, Simin Liu, Wenjun Li, Karen C Johnson, Jean Wactawski-Wende, Aladdin H Shadyab, Margery L Gass, Victor Kamensky and 2 more

Registry-linked trialOpen access · goldAbstract readMulticenter StudyObservational StudyRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in BMJ open, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00000611 (Women's Health Initiative), which is not on this map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.4field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT00000611 phase3completednot on this map

Women's Health Initiative (WHI)

TypeinterventionalSponsorNational Heart, Lung, and Blood Institute (NHLBI)ConditionsBone Diseases, Breast Neoplasms, Cardiovascular Diseases, Colonic NeoplasmsArmshormone replacement therapy, estrogens, progestins, estrogen replacement therapy, diet, fat-restricted
3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Bone Health in Patients with Dyslipidemias: An Underestimated Aspect.International journal of molecular sciences · 2022
    Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 11 institutions in 2 countries.

Bernhard HaringDepartment of Internal Medicine I, University of Würzburg, Würzburg, Germany.
Carolyn J CrandallDepartment of Medicine, University of California, Los Angeles, California, USA.
Laura CarboneDepartment of Medicine, Augusta University Medical College of Georgia, Augusta, Georgia, USA.
Simin LiuDepartment of Epidemiology and Medicine, Brown University, Providence, Rhode Island, USA.
Wenjun LiDepartment of Medicine, University of Massachusetts Medical School, Worcester, Massachusetts, USA.
Karen C JohnsonDepartment of Preventive Medicine, University of Tennessee Health Science Center, Memphis, Tennessee, USA.
Jean Wactawski-WendeDepartment of Epidemiology and Environmental Health, University at Buffalo, Buffalo, New York, USA.
Aladdin H ShadyabDepartment of Family Medicine and Public Health, University of California San Diego, La Jolla, California, USA.
Margery L GassNorth American Menopause Society, Cleveland, Ohio, USA.
Victor KamenskyDepartment of Epidemiology and Population Health, Albert Einstein College of Medicine, Bronx, New York, USA.
Jane A CauleyDepartment of Epidemiology, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
Sylvia Wassertheil-SmollerDepartment of Epidemiology and Population Health, Albert Einstein College of Medicine, Bronx, New York, USA.
Albert Einstein College of Medicine · USAugusta University · USBrown University · USNorth American Menopause Society · USUniversity at Buffalo, State University of New York · USUniversity of California, Los Angeles · USUniversity of California, San Diego · USUniversity of Massachusetts Chan Medical School · USUniversity of Pittsburgh · USUniversity of Tennessee Health Science Center · USUniversity of Würzburg · DE

Funding

Translational Research CoreP30DK020541 · NIDDK · ALBERT EINSTEIN COLLEGE OF MEDICINE, INC · PI Shuibing Chen · 2015 to 2026
$27.7M
Rheumatic Diseases Research Training GrantT32AR064194 · NIAMS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI GARY S FIRESTEIN, Monica Guma · 2013 to 2026
$3.8M
NHLBI NIH HHS HHSN268201600001CNHLBI NIH HHS HHSN268201600002CNHLBI NIH HHS HHSN268201600003CNHLBI NIH HHS HHSN268201600004CNHLBI NIH HHS HHSN268201600018CNIAMS NIH HHS T32 AR064194NIDDK NIH HHS P30 DK020541
6 · The paper itself

Abstract

objectivesElevated Lipoprotein(a) (Lp[a]) is a well-known risk factor for cardiovascular disease. However, its roles in bone metabolism and fracture risk are unclear. We therefore investigated whether plasma Lp(a) levels were associated with bone mineral density (BMD) and incident hip fractures in a large cohort of postmenopausal women.

designPost hoc analysis of data from the Women's Health Initiative (WHI), USA.

setting40 clinical centres in the USA.

participantsThe current analytical cohort consisted of 9698 white, postmenopausal women enrolled in the WHI, a national prospective study investigating determinants of chronic diseases including heart disease, breast and colorectal cancers and osteoporotic fractures among postmenopausal women. Recruitment for WHI took place from 1 October 1993 to 31 December 1998. EXPOSURES: Plasma Lp(a) levels were measured at baseline. OUTCOME MEASURES: Incident hip fractures were ascertained annually and confirmed by medical records with follow-up through 29 August 2014. BMD at the femoral neck was measured by dual X-ray absorptiometry in a subset of participants at baseline. STATISTICAL ANALYSES: Cox proportional hazards and logistic regression models were used to evaluate associations of quartiles of plasma Lp(a) levels with hip fracture events and hip BMD T-score, respectively.

resultsDuring a mean follow-up of 13.8 years, 454 incident cases of hip fracture were observed. In analyses adjusting for confounding variables including age, body mass index, history of hysterectomy, smoking, physical activity, diabetes mellitus, general health status, cardiovascular disease, use of menopausal hormone therapy, use of bisphosphonates, calcitonin or selective-oestrogen receptor modulators, baseline dietary and supplemental calcium and vitamin D intake and history of fracture, no significant association of plasma Lp(a) levels with low hip BMD T-score or hip fracture risk was detected.

conclusionsThese findings suggest that plasma Lp(a) levels are not related to hip BMD T-score or hip fracture events in postmenopausal women. TRIAL REGISTRATION NUMBER: NCT00000611; Post-results.

Indexed as

Bone DensityWomen's HealthAbsorptiometry, PhotonAgedBody Mass IndexDietFemaleFemur NeckHip FracturesHumansLipoprotein(a)Logistic ModelsMiddle AgedOsteoporosis, PostmenopausalPostmenopauseProportional Hazards ModelsLipoprotein(a)bone mineral densityfractureslipoprotein (a)postmenopausal women

Identifiers

PMID31023762
PMCPMC6501983
OpenAlexW2941668472

What Socratic holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.