Evidence map›Paper›PMID 31024796›Full record

ReviewPhotoacoustics2019

Cardiovascular optoacoustics: From mice to men - A review.

Angelos Karlas, Nikolina-Alexia Fasoula, Korbinian Paul-Yuan, Josefine Reber, Michael Kallmayer, Dmitry Bozhko, Markus Seeger, Hans-Henning Eckstein, Moritz Wildgruber, Vasilis Ntziachristos

Abstract readReview
In one paragraph

Review in Photoacoustics, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 57 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
57citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

57 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Optoacoustic muscle imaging.Journal of neuromuscular diseases · 2026
    Review
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Review
  12. Article
  13. Article
  14. Review
  15. Mouse Cardiovascular Imaging.Current protocols · 2024
    Review
  16. Article
  17. Article
  18. Review
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Angelos KarlasChair of Biological Imaging, TranslaTUM, Technical University of Munich, Munich, Germany.
Nikolina-Alexia FasoulaChair of Biological Imaging, TranslaTUM, Technical University of Munich, Munich, Germany.
Korbinian Paul-YuanChair of Biological Imaging, TranslaTUM, Technical University of Munich, Munich, Germany.
Josefine ReberInstitute of Biological and Medical Imaging, Helmholtz Zentrum München, Neuherberg, Germany.
Michael KallmayerClinic for Vascular and Endovascular Surgery, University Hospital rechts der Isar, Munich, Germany.
Dmitry BozhkoChair of Biological Imaging, TranslaTUM, Technical University of Munich, Munich, Germany.
Markus SeegerChair of Biological Imaging, TranslaTUM, Technical University of Munich, Munich, Germany.
Hans-Henning EcksteinClinic for Vascular and Endovascular Surgery, University Hospital rechts der Isar, Munich, Germany.
Moritz WildgruberInstitute for Diagnostic and Interventional Radiology, University Hospital rechts der Isar, Munich, Germany.
Vasilis NtziachristosChair of Biological Imaging, TranslaTUM, Technical University of Munich, Munich, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Imaging has become an indispensable tool in the research and clinical management of cardiovascular disease (CVD). An array of imaging technologies is considered for CVD diagnostics and therapeutic assessment, ranging from ultrasonography, X-ray computed tomography and magnetic resonance imaging to nuclear and optical imaging methods. Each method has different operational characteristics and assesses different aspects of CVD pathophysiology; nevertheless, more information is desirable for achieving a comprehensive view of the disease. Optoacoustic (photoacoustic) imaging is an emerging modality promising to offer novel information on CVD parameters by allowing high-resolution imaging of optical contrast several centimeters deep inside tissue. Implemented with illumination at several wavelengths, multi-spectral optoacoustic tomography (MSOT) in particular, is sensitive to oxygenated and deoxygenated hemoglobin, water and lipids allowing imaging of the vasculature, tissue oxygen saturation and metabolic or inflammatory parameters. Progress with fast-tuning lasers, parallel detection and advanced image reconstruction and data-processing algorithms have recently transformed optoacoustics from a laboratory tool to a promising modality for small animal and clinical imaging. We review progress with optoacoustic CVD imaging, highlight the research and diagnostic potential and current applications and discuss the advantages, limitations and possibilities for integration into clinical routine.

Indexed as

Cardiovascular diseaseNon-invasive

Identifiers

PMID31024796
PMCPMC6476795

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.