Evidence map›Paper›PMID 31028280›Full record

ArticleJournal of exposure science & environmental epidemiology2019

Pathway analysis of a genome-wide gene by air pollution interaction study in asthmatic children.

Despo Ierodiakonou, Brent A Coull, Antonella Zanobetti, Dirkje S Postma, H Marike Boezen, Judith M Vonk, Edward F McKone, Jonathan S Schildcrout, Gerard H Koppelman, Damien C Croteau-Chonka and 5 more

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of exposure science & environmental epidemiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.8field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 14 citations in OpenAlex.

  1. Genetic susceptibility to respiratory health effects from outdoor air pollution: a structured narrative review.European respiratory review : an official journal of the European Respiratory Society · 2026
    Review
  2. Review
  3. Ambient air pollution sensitivity and severity of pediatric asthma.Journal of exposure science & environmental epidemiology · 2024
    Article
  4. Article
  5. The role of gene-ambient air pollution interactions in paediatric asthma.European respiratory review : an official journal of the European Respiratory Society · 2022
    Review
  6. Review
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 6 institutions in 4 countries.

Despo IerodiakonouDepartment of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands. desierod@gmail.com.
Brent A CoullDepartment of Biostatistics, Harvard T.H. Chan School of Public Health, Boston, MA, United States.
Antonella ZanobettiEnvironmental Epidemiology and Risk Program, Harvard T.H. Chan School of Public Health, Boston, MA, United States.
Dirkje S PostmaGroningen Research Institute for Asthma and COPD, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
H Marike BoezenDepartment of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
Judith M VonkDepartment of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
Edward F McKoneDepartment of Respiratory Medicine, St. Vincent University Hospital, Dublin, Ireland.
Jonathan S SchildcroutDepartment of Environmental and Occupational Health Sciences, School of Public Health, University of Washington, Seattle, WA, United States.
Gerard H KoppelmanGroningen Research Institute for Asthma and COPD, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
Damien C Croteau-ChonkaChanning Division of Network Medicine, Brigham and Women's Hospital, Department of Medicine, Harvard Medical School, Boston, MA, United States.
Thomas LumleyDepartment of Biostatistics, University of Auckland, Auckland, New Zealand.
Petros KoutrakisEnvironmental Epidemiology and Risk Program, Harvard T.H. Chan School of Public Health, Boston, MA, United States.
Joel SchwartzEnvironmental Epidemiology and Risk Program, Harvard T.H. Chan School of Public Health, Boston, MA, United States.
Diane R GoldEnvironmental Epidemiology and Risk Program, Harvard T.H. Chan School of Public Health, Boston, MA, United States.
Scott T WeissChanning Division of Network Medicine, Brigham and Women's Hospital, Department of Medicine, Harvard Medical School, Boston, MA, United States.
Harvard University · USUniversity Medical Center Groningen · NLUniversity of Groningen · NLSt. Vincent's University Hospital · IEUniversity of Auckland · NZUniversity of Washington · US

Funding

CTSA INFRASTRUCTURE FOR PEDIATRIC RESEARCHUL1RR025780 · NCRR · UNIVERSITY OF COLORADO DENVER · PI SOKOL, RONALD J. · 2008 to 2011
$61.3M
ZOPOLRESTAT PHARMACOKINETICS IN DIABETICS WITH VARYING RENAL FUNCTIONM01RR000051 · NCRR · UNIVERSITY OF COLORADO DENVER · PI KRUGMAN, RICHARD D. · 1985 to 2008
$52.6M
Translational Research Support CoreP30ES000002 · NIEHS · HARVARD UNIVERSITY (SCH OF PUBLIC HLTH) · PI Brent Andrew Coull · 1985 to 2026
$44.6M
THE PHARMACOGENETICS OF ASTHMA TREATMENTU01HL065899 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI TANTISIRA, KELAN G, WEISS, SCOTT T · 2000 to 2014
$38.5M
YOGA FOR THE MANAGEMENT OF HIV-METABOLIC SYNDROMESM01RR000036 · NCRR · WASHINGTON UNIVERSITY · PI SHAPIRO, LARRY J · 1985 to 2007
$25.4M
Colorado Clinical and Translational Science Institute (UL1)UL1TR000154 · NCATS · UNIVERSITY OF COLORADO DENVER · PI SOKOL, RONALD J. · 2012 to 2013
$20.4M
ZINC THERAPY FOR SCLERODERMA--PHASE I STUDYM01RR002719 · NCRR · JOHNS HOPKINS UNIVERSITY · PI OUYANG, PAMELA · 1986 to 2007
$20.2M
Effect of Ambient Particles on Acute Stroke OnsetP01ES009825 · NIEHS · HARVARD UNIVERSITY (SCH OF PUBLIC HLTH) · PI SUH, HELEN · 1999 to 2009
$17.4M
Statistical GeneticsP01HL083069 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI WEISS, SCOTT T · 2007 to 2011
$12.2M
The Asthma BioRepository for Integrative Genomics ResearchRC2HL101543 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI RABY, BENJAMIN ALEXANDER, WEISS, SCOTT T · 2009 to 2010
$8.3M
Genetics and Gene Expression Profiling in AsthmaR01HL086601 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI RABY, BENJAMIN ALEXANDER · 2007 to 2015
$6.8M
CAMPCS/3U01HL075408 · NHLBI · JOHNS HOPKINS UNIVERSITY · PI TONASCIA, JAMES A · 2003 to 2010
$4.9M
NCATS NIH HHS UL1 TR000154NCRR NIH HHS M01 RR000036NCRR NIH HHS M01 RR000051NCRR NIH HHS M01 RR002719NCRR NIH HHS UL1 RR025780NHLBI NIH HHS N01 HR016044NHLBI NIH HHS N01HR16045NHLBI NIH HHS N01HR16046NHLBI NIH HHS N01HR16047NHLBI NIH HHS N01HR16048NHLBI NIH HHS N01HR16049NHLBI NIH HHS N01HR16050NHLBI NIH HHS N01HR16051NHLBI NIH HHS N01HR16052NHLBI NIH HHS P01 HL083069NHLBI NIH HHS R01 HL086601NHLBI NIH HHS RC2 HL101543NHLBI NIH HHS U01 HL065899NHLBI NIH HHS U01 HL075232NHLBI NIH HHS U01 HL075407NHLBI NIH HHS U01 HL075408NHLBI NIH HHS U01 HL075409NHLBI NIH HHS U01 HL075415NHLBI NIH HHS U01 HL075416NHLBI NIH HHS U01 HL075417NHLBI NIH HHS U01 HL075419NHLBI NIH HHS U01 HL075420NIEHS NIH HHS P01 ES009825NIEHS NIH HHS P30 ES000002NIEHS NIH HHS R21 ES020194
6 · The paper itself

Abstract

objectivesWe aimed to investigate the role of genetics in the respiratory response of asthmatic children to air pollution, with a genome-wide level analysis of gene by nitrogen dioxide (NO

methodsWe used a two-step method for fast linear mixed model computations for genome-wide association studies, exploring whether variants modify the longitudinal relationship between 4-month average pollution and post-bronchodilator FEV

resultsTwo SNPs near the EPHA3 (rs13090972 and rs958144) and one in TXNDC8 (rs7041938) showed significant interactions with NO

conclusionThe host lung function response to long-term exposure to pollution is linked to genes involved in cellular adhesion, oxidative stress, inflammatory, and metabolic pathways.

Indexed as

Genome-Wide Association StudyAir PollutantsAsthmaCarbon MonoxideChildFemaleHumansLungMaleNitrogen DioxideRespiratory Function TestsAir PollutantsCarbon MonoxideNitrogen DioxideAir pollutionAsthmaGene–environment interactionGenome-wideLung functionPathways.

Identifiers

PMID31028280
PMCPMC10730425
OpenAlexW2942429967

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.