ArticlePhysiological reports2019
Preserved ability to blunt sympathetically-mediated vasoconstriction in exercising skeletal muscle of young obese humans.
Article in Physiological reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
4 citing papers in PubMed, 9 citations in OpenAlex.
- Endothelial and exercise vasodilation are reduced in postmenopausal females with obesity versus lean and overweight.International journal of obesity (2005) · 2024Article
- α-Adrenergic regulation of skeletal muscle blood flow during exercise in patients with heart failure with preserved ejection fraction.The Journal of physiology · 2024Article
- Evidence of impaired functional sympatholysis in patients with heart failure with preserved ejection fraction.American journal of physiology. Heart and circulatory physiology · 2023Article
- Preserved ability to blunt sympathetically-mediated vasoconstriction in exercising skeletal muscle of young obese humans.Physiological reports · 2019Article
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Authors and funding
9 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Sympathetic vasoconstriction is attenuated in exercising muscles to assist in matching of blood flow with metabolic demand. This "functional sympatholysis" may be impaired in young obese individuals due to greater sympathetic activation and/or reduced local vasodilatory capacity of both small and large arteries, but this remains poorly understood. We tested the hypothesis that functional sympatholysis is impaired in obese individuals compared with normal-weight counterparts. In 36 obese and normal-weight young healthy adults (n = 18/group), we measured forearm blood flow and calculated forearm vascular conductance (FVC) responses to reflex increases in sympathetic nerve activity induced by lower body negative pressure (LBNP) at rest and during rhythmic handgrip exercise at 15% and 30% of the maximal voluntary contraction (MVC). FVC was normalized to lean forearm mass. In normal-weight individuals, LBNP evoked a decrease in FVC (-16.1 ± 5.7%) in the resting forearm, and the reduction in FVC (15%MVC: -8.1 ± 3.3%; 30%MVC: -1.0 ± 4.0%) was blunted during exercise in an intensity-dependent manner (P < 0.05). Similarly, in obese individuals, LBNP evoked a comparable decrease in FVC (-10.9 ± 5.7%) in the resting forearm, with the reduction in FVC (15%MVC: -9.7 ± 3.3%; 30%MVC: -0.3 ± 4.0%) also blunted during exercise in an intensity-dependent manner (P < 0.05). The magnitude of sympatholysis was similar between groups (P > 0.05) and was intensity-dependent (P < 0.05). Our findings suggest that functional sympatholysis is not impaired in young obese individuals without overt cardiovascular diseases.
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