Evidence map›Paper›PMID 31039329›Full record

ReviewAnnual review of virology2019

Idiosyncrasies of Viral Noncoding RNAs Provide Insights into Host Cell Biology.

Johanna B Withers, Vanessa Mondol, Paulina Pawlica, Nicolle A Rosa-Mercado, Kazimierz T Tycowski, Salehe Ghasempur, Seyed F Torabi, Joan A Steitz

Open access · greenAbstract readReview
In one paragraph

Review in Annual review of virology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed, 1 pooled it
1.1field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 1 synthesis or guideline pooled it, 28 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Article
  4. Review
  5. Review
  6. Article
  7. Article
  8. Review
  9. Shaping the host cell environment with viral noncoding RNAs.Seminars in cell & developmental biology · 2023
    Review
  10. Review
  11. Review
  12. Article
  13. Article
  14. Review
  15. Article
  16. SARS-CoV-2 expresses a microRNA-like small RNA able to selectively repress host genes.Proceedings of the National Academy of Sciences of the United States of America · 2021
    Article
  17. Review
  18. Article
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Johanna B WithersDepartment of Molecular Biophysics and Biochemistry, Boyer Center for Molecular Medicine, Yale University School of Medicine, New Haven, Connecticut 06536, USA; email: johanna.withers@yale.edu, vanessa.mondol@yale.edu, paulina.pawlica@yale.edu, nicolle.rosa-mercado@yale.edu, ktt@yale.edu, salehe.ghasempur@yale.edu, seyed.torabi@yale.edu, joan.steitz@yale.edu.
Vanessa MondolDepartment of Molecular Biophysics and Biochemistry, Boyer Center for Molecular Medicine, Yale University School of Medicine, New Haven, Connecticut 06536, USA; email: johanna.withers@yale.edu, vanessa.mondol@yale.edu, paulina.pawlica@yale.edu, nicolle.rosa-mercado@yale.edu, ktt@yale.edu, salehe.ghasempur@yale.edu, seyed.torabi@yale.edu, joan.steitz@yale.edu.
Paulina PawlicaDepartment of Molecular Biophysics and Biochemistry, Boyer Center for Molecular Medicine, Yale University School of Medicine, New Haven, Connecticut 06536, USA; email: johanna.withers@yale.edu, vanessa.mondol@yale.edu, paulina.pawlica@yale.edu, nicolle.rosa-mercado@yale.edu, ktt@yale.edu, salehe.ghasempur@yale.edu, seyed.torabi@yale.edu, joan.steitz@yale.edu.
Nicolle A Rosa-MercadoDepartment of Molecular Biophysics and Biochemistry, Boyer Center for Molecular Medicine, Yale University School of Medicine, New Haven, Connecticut 06536, USA; email: johanna.withers@yale.edu, vanessa.mondol@yale.edu, paulina.pawlica@yale.edu, nicolle.rosa-mercado@yale.edu, ktt@yale.edu, salehe.ghasempur@yale.edu, seyed.torabi@yale.edu, joan.steitz@yale.edu.
Kazimierz T TycowskiDepartment of Molecular Biophysics and Biochemistry, Boyer Center for Molecular Medicine, Yale University School of Medicine, New Haven, Connecticut 06536, USA; email: johanna.withers@yale.edu, vanessa.mondol@yale.edu, paulina.pawlica@yale.edu, nicolle.rosa-mercado@yale.edu, ktt@yale.edu, salehe.ghasempur@yale.edu, seyed.torabi@yale.edu, joan.steitz@yale.edu.
Salehe GhasempurDepartment of Molecular Biophysics and Biochemistry, Boyer Center for Molecular Medicine, Yale University School of Medicine, New Haven, Connecticut 06536, USA; email: johanna.withers@yale.edu, vanessa.mondol@yale.edu, paulina.pawlica@yale.edu, nicolle.rosa-mercado@yale.edu, ktt@yale.edu, salehe.ghasempur@yale.edu, seyed.torabi@yale.edu, joan.steitz@yale.edu.
Seyed F TorabiDepartment of Molecular Biophysics and Biochemistry, Boyer Center for Molecular Medicine, Yale University School of Medicine, New Haven, Connecticut 06536, USA; email: johanna.withers@yale.edu, vanessa.mondol@yale.edu, paulina.pawlica@yale.edu, nicolle.rosa-mercado@yale.edu, ktt@yale.edu, salehe.ghasempur@yale.edu, seyed.torabi@yale.edu, joan.steitz@yale.edu.
Joan A SteitzDepartment of Molecular Biophysics and Biochemistry, Boyer Center for Molecular Medicine, Yale University School of Medicine, New Haven, Connecticut 06536, USA; email: johanna.withers@yale.edu, vanessa.mondol@yale.edu, paulina.pawlica@yale.edu, nicolle.rosa-mercado@yale.edu, ktt@yale.edu, salehe.ghasempur@yale.edu, seyed.torabi@yale.edu, joan.steitz@yale.edu.
Yale University · USHoward Hughes Medical Institute · US

Funding

VIRAL SMALL RNPS--ROLES IN CELL TRANSFORMATIONP01CA016038 · NCI · YALE UNIVERSITY · PI DIMAIO, DANIEL C. · 1985 to 2020
$25.6M
Predoctoral Training Program in VirologyT32AI055403 · NIAID · YALE UNIVERSITY · PI KUMAR, PRITI, MOTHES, WALTHER H · 2003 to 2024
$3.6M
Regulation of microRNA populations by oncogenic virusesK99GM129412 · NIGMS · YALE UNIVERSITY · PI PAWLICA, PAULINA · 2018 to 2020
$200k
Howard Hughes Medical InstituteNCI NIH HHS P01 CA016038NIAID NIH HHS T32 AI055403NIGMS NIH HHS K99 GM129412
6 · The paper itself

Abstract

Like their host cells, many viruses express noncoding RNAs (ncRNAs). Despite the technical challenge of ascribing function to ncRNAs, diverse biological roles for virally expressed ncRNAs have been described, including regulation of viral replication, modulation of host gene expression, host immune evasion, cellular survival, and cellular transformation. Insights into conserved interactions between viral ncRNAs and host cell machinery frequently lead to novel findings concerning host cell biology. In this review, we discuss the functions and biogenesis of ncRNAs produced by animal viruses. Specifically, we describe noncanonical pathways of microRNA (miRNA) biogenesis and novel mechanisms used by viruses to manipulate miRNA and messenger RNA stability. We also highlight recent advances in understanding the function of viral long ncRNAs and circular RNAs.

Indexed as

Gene Expression Regulation, ViralHost Microbial InteractionsRNA, UntranslatedAnimalsMicroRNAsRNA, CircularRNA, ViralVirusesVirus ReplicationMicroRNAsRNA, CircularRNA, UntranslatedRNA, Viralnoncoding RNAvirusesvirus-host interactions

Identifiers

PMID31039329
PMCPMC6768742
OpenAlexW2942811828

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.