ReviewCerebrovascular diseases extra2019
Nonsteroidal Anti-Inflammatory Drugs: A Potential Pharmacological Treatment for Intracranial Aneurysm.
Review in Cerebrovascular diseases extra, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 3 syntheses or guidelines pooled it, 23 citations in OpenAlex.
- The effect of aspirin on inflammatory response in intracranial aneurysm: a systematic review.Inflammopharmacology · 2025Pooled it
- Non-steroidal anti-inflammatory drugs in the pathophysiology of vasospasms and delayed cerebral ischemia following subarachnoid hemorrhage: a critical review.Neurosurgical review · 2021Pooled it
- In the wall lies the truth: a systematic review of diagnostic markers in intracranial aneurysms.Brain pathology (Zurich, Switzerland) · 2020Pooled it
- The effect of aspirin on aneurysm wall enhancement: A study in rabbits and humans.Interventional neuroradiology : journal of peritherapeutic neuroradiology, surgical procedures and related neurosciences · 2025Article
- Isolation and focal treatment of brain aneurysms using interfacial fluid trapping.Science advances · 2024Article
- Aspirin treatment for unruptured intracranial aneurysms: Focusing on its anti-inflammatory role.Heliyon · 2024Review
- Regular medication as a risk factor for intracranial aneurysms: A comparative case-control study.European stroke journal · 2023Article
- Aspirin treatment prevents inflammation in experimental bifurcation aneurysms in New Zealand White rabbits.Journal of neurointerventional surgery · 2022Article
- Biophysical targeting of high-risk cerebral aneurysms.Bioengineering & translational medicine · 2022Article
- Disturbed flow's impact on cellular changes indicative of vascular aneurysm initiation, expansion, and rupture: A pathological and methodological review.Journal of cellular physiology · 2022Review
- Repeated Aneurysm Intervention.Advances and technical standards in neurosurgery · 2022Article
- Intracranial Aneurysms Induced byFrontiers in neurology · 2022Article
- Progressive volume reduction and long-term aneurysmal collapse following flow diversion treatment of giant and symptomatic cerebral aneurysms.Frontiers in neurology · 2022Article
- Integrated analysis identifies the IL6/JAK/STAT signaling pathway and the estrogen response pathway associated with the pathogenesis of intracranial aneurysms.Frontiers in immunology · 2022Article
- Shedding the Light on the Natural History of Intracranial Aneurysms: An Updated Overview.Medicina (Kaunas, Lithuania) · 2021Review
- The effective interplay of (non-) selective NSAIDs with neostigmine in animal models of analgesia and inflammation.BMC pharmacology & toxicology · 2021Article
- On the Potential Self-Amplification of Aneurysms Due to Tissue Degradation and Blood Flow Revealed From FSI Simulations.Frontiers in physiology · 2021Article
- Endovascular Biopsy of Vertebrobasilar Aneurysm in Patient With Polyarteritis Nodosa.Frontiers in neurology · 2021Article
- Effect of combined acetylsalicylic acid and statins treatment on intracranial aneurysm rupture.PloS one · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
backgroundSaccular intracranial aneurysms (IAs) are outpouchings of the vessel wall of intracranial arteries. Rupture of IAs results in subarachnoid hemorrhage which is associated with high morbidity and mortality. Surgical interventions, such as clipping and coiling, have associated risks. Currently, there are no proven pharmacological treatments to prevent the growth or rupture of IAs. Infiltration of proinflammatory cytokines in response to increased wall sheer stress is a hallmark of IA. Nonsteroidal anti-inflammatory drugs (NSAIDs) are being investigated as potential therapeutic agents for reduction in growth and/or prevention of IA through inhibition of inflammatory pathways. SUMMARY: This review will discuss the role of NSAIDs in attenuating the inflammation that drives IA progression and rupture. There are two main subtypes of NSAIDs, nonselective COX and selective COX-2 inhibitors, both of which have merit in treating IA. Evidence will be presented which shows that NSAIDs inhibit several key inflammatory mediators involved in IA progression including nuclear factor-κB, tumor necrosis factor-α, and matrix metalloproteinases. In addition, the role of NSAIDs in limiting inflammatory cell adhesion to endothelial cells and attenuating endothelial cell senescence will be discussed. Key Messages: There is an abundance of basic science and preclinical data that support NSAIDs as a promising treatment for IA. Additionally, a combination treatment strategy of low-dose aspirin given concomitantly with a selective COX-2 inhibitor may result in a reduced side effect profile compared to aspirin or selective COX-2 inhibitor use alone. Several large clinical trials are currently planned to further investigate the efficacy of NSAIDs as an effective nonsurgical treatment for IAs.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.