Evidence map›Paper›PMID 31048401›Full record

ArticleG3 (Bethesda, Md.)2019

Quantitative Comparison of the Anterior-Posterior Patterning System in the Embryos of Five

Zeba Wunderlich, Charless C Fowlkes, Kelly B Eckenrode, Meghan D J Bragdon, Arash Abiri, Angela H DePace

Abstract read
In one paragraph

Article in G3 (Bethesda, Md.), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Article
  3. Evolution of larval segment position across 12 Drosophila species.Evolution; international journal of organic evolution · 2020
    Article
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Zeba WunderlichDepartment of Developmental and Cell Biology, University of California, Irvine, CA, 92697 zeba@uci.edu.ORCID 0000-0003-4491-5715
Charless C FowlkesDepartment of Computer Science, University of California, Irvine, CA, 92697.
Kelly B EckenrodeDepartment of Systems Biology, Harvard Medical School, Boston, MA, 20115.
Meghan D J BragdonDepartment of Systems Biology, Harvard Medical School, Boston, MA, 20115.ORCID 0000-0003-4301-5264
Arash AbiriDepartment of Developmental and Cell Biology, University of California, Irvine, CA, 92697.
Angela H DePaceDepartment of Systems Biology, Harvard Medical School, Boston, MA, 20115.ORCID 0000-0001-5723-0438

Funding

Mechanisms of shadow enhancer robustness during developmentR01HD095246 · NICHD · UNIVERSITY OF CALIFORNIA-IRVINE · PI Zeba B Wunderlich · 2018 to 2026
$2.7M
Dissecting expression divergence in developmental networks across DrosophilidsR00HD073191 · NICHD · UNIVERSITY OF CALIFORNIA-IRVINE · PI WUNDERLICH, ZEBA B · 2015 to 2017
$745k
Programmable metafluorophores for quantitative multiplex in situ imaging of mRNAR21HD072481 · NICHD · HARVARD MEDICAL SCHOOL · PI YIN, PENG · 2012 to 2013
$452k
Dissecting expression divergence in developmental networks across DrosophilidsK99HD073191 · NICHD · HARVARD MEDICAL SCHOOL · PI WUNDERLICH, ZEBA B · 2012 to 2013
$258k
NICHD NIH HHS K99 HD073191NICHD NIH HHS R00 HD073191NICHD NIH HHS R01 HD095246NICHD NIH HHS R21 HD072481
6 · The paper itself

Abstract

Complex spatiotemporal gene expression patterns direct the development of the fertilized egg into an adult animal. Comparisons across species show that, in spite of changes in the underlying regulatory DNA sequence, developmental programs can be maintained across millions of years of evolution. Reciprocally, changes in gene expression can be used to generate morphological novelty. Distinguishing between changes in regulatory DNA that lead to changes in gene expression and those that do not is therefore a central goal of evolutionary developmental biology. Quantitative, spatially-resolved measurements of developmental gene expression patterns play a crucial role in this goal, enabling the detection of subtle phenotypic differences between species and the development of computations models that link the sequence of regulatory DNA to expression patterns. Here we report the generation of two atlases of cellular resolution gene expression measurements for the primary anterior-posterior patterning genes in

Indexed as

Body PatterningEmbryonic DevelopmentAnimalsBiomarkersDrosophilaEmbryo, NonmammalianGene Expression ProfilingGene Expression Regulation, DevelopmentalGene Regulatory NetworksOrgan SpecificitySpecies SpecificityTranscriptomeBiomarkersDrosophilaembryoevo-devogene expressiongene regulatory network

Identifiers

PMID31048401
PMCPMC6643877

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.