Evidence map›Paper›PMID 31054032›Full record

Trial reportBreast cancer research and treatment2019

Efficacy of a web-based women's health survivorship care plan for young breast cancer survivors: a randomized controlled trial.

H Irene Su, Shaylyn Stark, Brian Kwan, Sarah Boles, Diana Chingos, Jennifer Ehren, Jessica R Gorman, Michael Krychman, Sally A D Romero, Jun J Mao and 2 more

Abstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Breast cancer research and treatment, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed, 3 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 3 syntheses or guidelines pooled it.

  1. Pooled it
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  3. Health information technology to support cancer survivorship care planning: A systematic review.Journal of the American Medical Informatics Association : JAMIA · 2021
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

H Irene SuDepartment of Obstetrics, Gynecology and Reproductive Sciences, University of California San Diego, San Diego, USA. hisu@ucsd.edu.ORCID http://orcid.org/0000-0002-6671-5151
Shaylyn StarkMoores Cancer Center, University of California San Diego, 3855 Health Sciences Drive, Dept. 0901, La Jolla, San Diego, CA, 92093-0901, USA.
Brian KwanMoores Cancer Center, University of California San Diego, 3855 Health Sciences Drive, Dept. 0901, La Jolla, San Diego, CA, 92093-0901, USA.
Sarah BolesMoores Cancer Center, University of California San Diego, 3855 Health Sciences Drive, Dept. 0901, La Jolla, San Diego, CA, 92093-0901, USA.
Diana ChingosYoung Survival Coalition, New York, USA.
Jennifer EhrenDepartment of Chemical and Biomolecular Engineering, University of Notre Dame, Notre Dame, USA.
Jessica R GormanSchool of Social and Behavioral Health Sciences, Oregon State University College of Public Health and Human Sciences, Corvalis, USA.
Michael KrychmanSouthern California Center for Sexual Health and Survivorship Medicine, Newport Beach, USA.
Sally A D RomeroBendheim Integrative Medicine Center, Memorial Sloan Kettering Cancer Center, New York, USA.
Jun J MaoBendheim Integrative Medicine Center, Memorial Sloan Kettering Cancer Center, New York, USA.
John P PierceMoores Cancer Center, University of California San Diego, 3855 Health Sciences Drive, Dept. 0901, La Jolla, San Diego, CA, 92093-0901, USA.
Loki NatarajanMoores Cancer Center, University of California San Diego, 3855 Health Sciences Drive, Dept. 0901, La Jolla, San Diego, CA, 92093-0901, USA.

Funding

X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI SELWYN M VICKERS · 1985 to 2026
$347.4M
The Reproductive Window in Young Adult Cancer SurvivorsR01HD080952 · NICHD · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI SU, HUI-CHUN IRENE · 2014 to 2018
$2.6M
California Breast Cancer Research Program 20OB-0144National Cancer Institute P30-CA008748NCI NIH HHS P30 CA008748NICHD NIH HHS R01 HD080952
6 · The paper itself

Abstract

purposeBreast cancer survivorship care plans (SCP) have limited content addressing women's health issues. This trial tested if young breast cancer survivors who receive a web-based, women's health SCP were more likely to improve on at least one of the four targeted issues (hot flashes, fertility-related concerns, contraception, and vaginal symptoms) compared to attention controls.

methodsA randomized controlled trial recruited female survivors ages 18-45 at diagnosis, 18-50 at enrollment, completed primary cancer treatment, and had a significant women's health issue: moderate or higher fertility-related concerns; ≥ 4 hot flashes/day with ≥ 1 of moderate severity; ≥ 1 moderate vaginal atrophy symptoms; or not contracepting/using less effective methods. Survivors underwent stratified, block randomization with equal allocation to intervention and control groups. The intervention group accessed the online SCP; controls accessed curated resource lists. In intention-to-treat analysis, the primary outcome of improvement in at least one issue by 24 weeks was compared by group.

results182 participants (86 intervention, 96 control), mean age 40.0 ± 5.9 and 4.4 ± 3.2 years since diagnosis, were randomized. 61 intervention group participants (70.9%) improved, compared to 55 controls (57.3%) (OR 1.82, 95% CI 0.99-3.4, p = 0.057). The following issue-specific improvements were observed in the intervention versus control arms: fertility-related concerns (27.9% vs. 14.6%, OR 2.3, 95% CI 1.1-4.8); hot flashes (58.5% vs. 55.8%, OR 1.1, 95% CI 0.57-2.2); vaginal symptoms (42.5% vs. 40.7%, OR 1.1, 95% CI 0.6-2.0); contraception (50% vs. 42.6%, OR 1.4, 95% CI 0.74-2.5).

conclusionsIn young breast cancer survivors, a novel, web-based SCP did not result in more change in the primary outcome of improvement in at least one of the four targeted women's health issues, than the attention control condition. The intervention was associated with improved infertility concerns, supporting efficacy of disseminating accessible, evidence-based women's health information to this population.

Indexed as

Cancer SurvivorsInsurance, HealthInternetSurvivorshipWomen's HealthAdultAgedAge FactorsBreast NeoplasmsComorbidityFemaleFollow-Up StudiesHealth PersonnelHumansMiddle AgedOdds RatioBreast cancerFertilityRandomized controlled trialReproductive healthSurvivorship care plan

Identifiers

PMID31054032
PMCPMC6626763

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.