ReviewPlant cell reports2019
Improvement of phytochemical production by plant cells and organ culture and by genetic engineering.
Review in Plant cell reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
25 citing papers in PubMed, 82 citations in OpenAlex.
- Advances in Functional Genomics and Biotechnology for Enhancing Therapeutic Potential of Medicinal Plants.International journal of molecular sciences · 2026Review
- Plant Bioactive Compounds at the Interface of Extraction Science, Green Nanoparticles and Applied Biotechnology: A Narrative Review.Molecules (Basel, Switzerland) · 2026Review
- In vitro adventitious root culture of Withania somnifera L.: a strategy for enhanced secondary metabolite production with therapeutic antioxidant and anti-inflammatory potential.Scientific reports · 2026Article
- Unraveling Nature's Pharmacy: Transforming Medicinal Plants into Modern Therapeutic Agents.Pharmaceutics · 2025Review
- Bioactivities and biotechnological tools for obtaining bioactive metabolites fromFood science and biotechnology · 2025Review
- Localization of Secondary Metabolites in Relict Gymnosperms of the GenusLife (Basel, Switzerland) · 2024Article
- Eco-friendly approaches to phytochemical production: elicitation and beyond.Natural products and bioprospecting · 2024Review
- Co-cultures from Plants and Cyanobacteria: A New Way for Production Systems in Agriculture and Bioprocess Engineering.Advances in biochemical engineering/biotechnology · 2024Review
- A review ofJournal of food science and technology · 2023Review
- Developments in biotechnological tools and techniques for production of reserpine.Applied microbiology and biotechnology · 2023Review
- Biogenic Synthesis of Copper-Based Nanomaterials Using Plant Extracts and Their Applications: Current and Future Directions.Nanomaterials (Basel, Switzerland) · 2022Review
- Turning Waste into Beneficial Resource: Implication of Ageratum conyzoides L. in Sustainable Agriculture, Environment and Biopharma Sectors.Molecular biotechnology · 2022Review
- Phytochemical Profiling and Assessment of Anticancer Activity ofPlants (Basel, Switzerland) · 2022Article
- Tap the sap - investigation of latex-bearing plants in the search of potential anticancer biopharmaceuticals.Frontiers in plant science · 2022Review
- Critical factors influencing in vitro propagation and modulation of important secondary metabolites inPlant cell, tissue and organ culture · 2022Review
- Engineering Considerations to Produce Bioactive Compounds from Plant Cell Suspension Culture in Bioreactors.Plants (Basel, Switzerland) · 2021Review
- Towards a Cardoon (International journal of molecular sciences · 2021Article
- Morphological and Chemical Diversity and Antioxidant Capacity of the Service Tree (Plants (Basel, Switzerland) · 2021Article
- Anti-Inflammatory Effects ofPlants (Basel, Switzerland) · 2021Article
- Efficient plant regeneration from embryogenic cell suspension cultures of Euonymus alatus.Scientific reports · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Plants display an amazing ability to synthesize a vast array of secondary metabolites that are an inexhaustible source of phytochemicals, bioactive molecules some of which impact the human health. Phytochemicals present in medicinal herbs and spices have long been used as natural remedies against illness. Plant tissue culture represents an alternative to whole plants as a source of phytochemicals. This approach spares agricultural land that can be used for producing food and other raw materials, thus favoring standardized phytochemical production regardless of climatic adversities and political events. Over the past 20 years, different strategies have been developed to increase the synthesis and the extraction of phytochemicals from tissue culture often obtaining remarkable results. Moreover, the availability of genomics and metabolomics tools, along with improved recombinant methods related to the ability to overexpress, silence or disrupt one or more genes of the pathway of interest promise to open new exciting possibilities of metabolic engineering. This review provides a general framework of the cellular and molecular tools developed so far to enhance the yield of phytochemicals. Additionally, some emerging topics such as the culture of cambial meristemoid cells, the selection of plant cell following the expression of genes encoding human target proteins, and the bioextraction of phytochemicals from plant material have been addressed. Altogether, the herein described techniques and results are expected to improve metabolic engineering tools aiming at improving the production of phytochemicals of pharmaceutical and nutraceutical interest.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.