Evidence map›Paper›PMID 31067131›Full record

Trial reportEuropean journal of preventive cardiology2019

The impact of aerobic and isometric exercise on different measures of dysfunctional high-density lipoprotein in patients with hypertension.

Nikolaos Pagonas, Stergios Vlatsas, Frederic Bauer, Felix S Seibert, B Sasko, I Buschmann, O Ritter, Theodoros Kelesidis, Timm H Westhoff

Abstract readComparative StudyRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in European journal of preventive cardiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Trial
  3. Article
  4. Review
  5. Reduced antioxidant high-density lipoprotein function in heart failure with preserved ejection fraction.Clinical research in cardiology : official journal of the German Cardiac Society · 2026
    Observational
  6. Article
  7. Article
  8. Article
  9. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors.

Nikolaos Pagonas1 Department of Cardiology, Medical University of Brandenburg, Germany.
Stergios Vlatsas3 Department of Nephrology, Charité - Campus Benjamin Franklin, Berlin, Germany.
Frederic Bauer2 Medical Department I, Marien Hospital Herne, Ruhr-University of Bochum, Germany.
Felix S Seibert2 Medical Department I, Marien Hospital Herne, Ruhr-University of Bochum, Germany.
B Sasko1 Department of Cardiology, Medical University of Brandenburg, Germany.
I Buschmann4 Department of Angiology, Medical University of Brandenburg, Germany.
O Ritter1 Department of Cardiology, Medical University of Brandenburg, Germany.
Theodoros Kelesidis5 Department of Medicine, David Geffen School of Medicine, University of California, LA, USA.
Timm H Westhoff2 Medical Department I, Marien Hospital Herne, Ruhr-University of Bochum, Germany.

Funding

Targeting early instigators of vascular inflammation to prevent and/or delay vascular aging in chronic treated HIVR01AG059502 · NIA · UT SOUTHWESTERN MEDICAL CENTER · PI KELESIDIS, THEODOROS · 2018 to 2022
$2.0M
Oxidized HDL in the intersection of HIV, immune activation and atherosclerosisK08AI108272 · NIAID · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI KELESIDIS, THEODOROS · 2013 to 2017
$915k
Elucidating the impact of molecular signatures of immune senescence on aging in chronic treated HIVR03AG059462 · NIA · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI KELESIDIS, THEODOROS · 2018 to 2019
$156k
NIAID NIH HHS K08 AI108272NIA NIH HHS R01 AG059502NIA NIH HHS R03 AG059462
6 · The paper itself

Abstract

backgroundExercise training increases high-density lipoprotein (HDL) cholesterol, but its effect on HDL function is unclear. In hypertensives, exercise improves endothelial dysfunction, which is related to HDL function. In the present study, we assess for the first time the effects of different exercise modalities on two cell-free assays of HDL function.

designThe study was conducted as a prospective randomized controlled trial in 75 hypertensive patients.

methodsPatients were randomized in three groups: (a) handgrip isometric training five times weekly; (b) placebo-handgrip; and (c) aerobic exercise training at least three times per week. HDL function was assessed in serum samples at baseline and after 12 weeks of training by two independent assays that determine the proinflammatory phenotype (haptoglobin content) of a specific amount of HDL (Haptoglobin-HDL [HPHDL]) and oxidized HDL (HDLox) as a measure of reduced antioxidant function of HDL. HDL function measures were normalized by the measures of a pooled control of sera from healthy participants and by HDL-C levels (normalized ratio, no units).

resultsAerobic exercise led to significant reduction of the HDLox from 0.99 ± 0.27 to 0.90 ± 0.29 (no units,

conclusionsAerobic but not isometric exercise improves the antioxidant function of HDL in patients with hypertension. This improvement correlates positively with reductions of blood pressure.

Indexed as

Blood PressureExerciseIsometric ContractionAdultAgedBiomarkersCholesterol, HDLFemaleGermanyHumansHypertensionLipoproteins, HDLMaleMiddle AgedOxidation-ReductionProspective StudiesBiomarkersCholesterol, HDLLipoproteins, HDLAerobic exerciseHDL functionhypertensionisometric exerciselipids

Identifiers

PMID31067131
PMCPMC6625884

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.