Evidence map›Paper›PMID 31070019›Full record

ArticleMolecular genetics & genomic medicine2019

The influence of ACYP2 polymorphisms on gastrointestinal cancer susceptibility in the Chinese Han population.

Xianglong Duan, Jiajing Hong, Fuchun Wang, Kun Wei, Pengyuan Wang, Feng Hou, Min Zhang, Dengfeng Liu, Dongya Yuan, Sida Liu

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular genetics & genomic medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed, 1 pooled it
0.6field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 1 synthesis or guideline pooled it, 3 citations in OpenAlex.

  1. Pooled it
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 5 institutions in 1 country.

Xianglong DuanThe Second Department of General Surgery, Shaanxi Provincial People's Hospital, Xi'an, China.
Jiajing HongCollege of Acupuncture and Massage, Changchun University of Traditional Chinese Medicine, Changchun, China.
Fuchun WangInstitute of Acupuncture and Massage, Changchun University of Traditional Chinese Medicine, Changchun, China.
Kun WeiMedical College, Yan'an University, Yan'an, China.
Pengyuan WangClinical Medical College, Xi'an Medical University, Xi'an, China.
Feng HouClinical Medical College, Xi'an Medical University, Xi'an, China.
Min ZhangMedical College, Yan'an University, Yan'an, China.
Dengfeng LiuClinical Medical College, Xi'an Medical University, Xi'an, China.
Dongya YuanKey Laboratory for Molecular Genetic Mechanisms and Intervention Research on High Altitude Disease of Tibet Autonomous Region, School of Medicine, Xizang Minzu University, Xianyang, China.
Sida LiuThe Second Department of General Surgery, Shaanxi Provincial People's Hospital, Xi'an, China.ORCID 0000-0003-2302-2301
Xi'an Medical University · CNChangchun University of Chinese Medicine · CNXizang Minzu University · CNYan'an University · CNShanxi Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundGastrointestinal cancer (GI cancer) is a type of cancer that has a high death rate. It has been reported that ACYP2 gene was associated with the development of gastric cancer and colorectal cancer, but it is not clear that the relationship between ACYP2 gene and GI cancer in Chinese Han population. This study aimed to investigate the association between polymorphisms of ACYP2 and GI cancer in the Chinese Han population.

methodsWe used Agena MassARRAY to determine the genotypes of 1,160 GI cancer patients and 495 healthy controls. The correlation between ACYP2 variants and GI cancer risk was examined by logistic regression analysis.

resultsWe identified that rs6713088 (OR = 1.17, 95% CI: 1.00-1.36, p = 0.047), rs843711 (OR = 1.17, 95 CI: 1.01-1.36, p = 0.035), and rs11896604 (OR = 1.20, 95% CI: 1.00-1.45, p = 0.048) were correlated with an increased risk of GI cancer under allele model. Rs11125529 under the recessive model (OR = 2.05, 95% CI: 1.00-4.23, p = 0.038), rs843711 in recessive model (OR = 1.37, 95% CI: 1.04-1.82, p = 0.026), and rs11896604 under log-additive model (OR = 1.23, 95% CI: 1.01-1.51, p = 0.042) were associated with an increased risk of GI cancer.

conclusionOur study suggested that polymorphisms of ACYP2 gene might be associated with susceptibility to GI cancer.

Indexed as

Polymorphism, Single NucleotideAcid Anhydride HydrolasesAcylphosphataseAdultAgedAllelesAsian PeopleCase-Control StudiesChinaFemaleGastrointestinal NeoplasmsGene FrequencyGenetic Predisposition to DiseaseGenotypeHaplotypesHumansAcid Anhydride HydrolasesAcylphosphataseACYP2 protein, humanACYP2 genecase-control studygastrointestinal cancerpolymorphisms

Identifiers

PMID31070019
PMCPMC6625334
OpenAlexW2943982631

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.