Evidence map›Paper›PMID 31070702›Full record

Trial reportThe journals of gerontology. Series A, Biological sciences and medical sciences2020

Comparative Effects of Angiotensin-Converting Enzyme Inhibitors and Angiotensin Receptor Blockers on Response to a Physical Activity Intervention in Older Adults: Results From the Lifestyle Interventions and Independence for Elders Study.

Joshua D Brown, Steven M Smith, Elsa S Strotmeyer, Stephen B Kritchevsky, Thomas M Gill, Steven N Blair, Roger A Fielding, Thomas W Buford, Marco Pahor, Todd M Manini

Open access · bronzeAbstract readComparative StudyRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in The journals of gerontology. Series A, Biological sciences and medical sciences, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.3field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 13 citations in OpenAlex.

  1. Serum Concentrations of Losartan Metabolites Correlate With Improved Physical Function in a Pilot Study of Prefrail Older Adults.The journals of gerontology. Series A, Biological sciences and medical sciences · 2022
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 8 institutions in 1 country.

Joshua D BrownDepartment of Pharmaceutical Outcomes and Policy, University of Florida College of Pharmacy, Gainesville.
Steven M SmithDepartment of Pharmacotherapy and Translational Research, University of Florida College of Pharmacy, Gainesville.
Elsa S StrotmeyerCenter for Aging and Population Health, Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pennsylvania.
Stephen B KritchevskySticht Center for Healthy Aging and Alzheimer's Prevention, Wake Forest School of Medicine, Winston-Salem, North Carolina.
Thomas M GillDepartment of Internal Medicine, Yale School of Medicine, New Haven, Connecticut.
Steven N BlairArnold School of Public Health, University of South Carolina, Columbia.
Roger A FieldingJean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, Boston, Massachusetts.
Thomas W BufordDepartment of Medicine, University of Alabama-Birmingham.
Marco PahorInstitute on Aging, Department of Aging and Geriatric Research, University of Florida College of Medicine, Gainesville.
Todd M ManiniInstitute on Aging, Department of Aging and Geriatric Research, University of Florida College of Medicine, Gainesville.
University of Florida · USCenter for Drug Evaluation and Research · USTufts University · USUniversity of Alabama at Birmingham · USUniversity of Pittsburgh · USUniversity of South Carolina · USWake Forest University · USYale University · US

Funding

Physical Exercise to Prevent Disability Pilot StudyU01AG022376 · WAKE FOREST UNIVERSITY HEALTH SCIENCES · 2003 to 2005
$10.9M
Yale Clinical and Translational Science AwardUL1TR001863 · YALE UNIVERSITY · 2025 to 2025
$9.9M
TREATMENT GOALS FOR PERSONS WITH MULTIFACTORIAL GERIATRIC HEALTH CONDITIONSP30AG021342 · YALE UNIVERSITY · 2002 to 2025
$8.0M
Wake Forest Claude D. Pepper OAIC - RenewalP30AG021332 · WAKE FOREST UNIVERSITY HEALTH SCIENCES · 2002 to 2025
$7.7M
TECHNOLOGY COREP30AG024827 · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · 2004 to 2025
$4.3M
University of Florida Older Americans Independence Center (OAIC)P30AG028740 · NIA · UNIVERSITY OF FLORIDA · 2022 to 2025
$4.3M
Research EducationP30AG031679 · BRIGHAM AND WOMEN'S HOSPITAL · 2025 to 2025
$1.4M
NCATS NIH HHS UL1 TR000142NCATS NIH HHS UL1 TR001863NCATS NIH HHS UL1 TR003142NCRR NIH HHS UL1 RR025744NHLBI NIH HHS K01 HL138172NIA NIH HHS K07 AG043587NIA NIH HHS P30 AG021332NIA NIH HHS P30 AG021342NIA NIH HHS P30 AG024827NIA NIH HHS P30 AG028740NIA NIH HHS P30 AG031679NIA NIH HHS R01 AG056769NIA NIH HHS U01 AG022376NICHD NIH HHS R24 HD065688
6 · The paper itself

Abstract

backgroundAngiotensin-converting enzyme inhibitors (ACEis) and angiotensin receptor blockers (ARBs) may protect against aging-related decline. This study directly compared ACEis and ARBs on associations with risk of mobility disability in older adults when combined with a physical activity intervention.

methodsThis was a secondary analysis of the Lifestyle Interventions and Independence for Elders (LIFE) trial. Participants aged 70-89 years were randomized to a physical activity or health education intervention. Outcomes included incident and persistent major mobility disability, injurious falls, short physical performance battery, and gait speed. For this analysis, only participants who reported ACEi or ARB use at baseline were included. Baseline differences between ACEi and ARB groups were adjusted for using inverse probability of treatment weights. Weighted Cox proportional hazard models and analysis of covariance models were used to evaluate the independent effects of medications and interaction effects with the intervention on each outcome.

resultsOf 1,635 participants in the Lifestyle Interventions and Independence for Elders study, 796 used either an ACEi (496, 62.3%) or ARB (300, 37.7%). Compared with ACEi users, ARB users had 28% lower risk (hazard ratio [HR] = 0.72 [0.60-0.85]) of incident major mobility disability and 35% (HR = 0.65 [0.52-0.82]) lower risk of persistent major mobility disability whereas no interaction between medication use and intervention was observed. Risk of injurious falls and changes in short physical performance battery or gait speed were not different between ARB and ACEi users.

conclusionsThese results suggest that ARBs may protect from major mobility disability by other mechanisms than improving physical performance.

Indexed as

ExerciseIndependent LivingLife StyleAgedAged, 80 and overAngiotensin-Converting Enzyme InhibitorsAngiotensin Receptor AntagonistsFemaleHumansHypertensionMalePhysical Functional PerformanceAngiotensin-Converting Enzyme InhibitorsAngiotensin Receptor AntagonistsAngiotensin-converting enzyme inhibitorsAngiotensin receptor blockersFallsMobilityRenin–angiotensin system

Identifiers

PMID31070702
PMCPMC7164526
OpenAlexW2944512348

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.