Evidence map›Paper›PMID 31077372›Full record

ReviewThe Journal of physiology2019

Aerobic exercise training and vascular function with ageing in healthy men and women.

Douglas R Seals, Erzsebet E Nagy, Kerrie L Moreau

Open access · bronzeAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in The Journal of physiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 121 papers, 16 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
121citing papers in PubMed, 16 pooled it
15.8field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

121 citing papers in PubMed, 16 syntheses or guidelines pooled it, 214 citations in OpenAlex.

  1. The Role of Estrogen in Mitochondrial Disease.Cellular and molecular neurobiology · 2025
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  9. Meta-Analysis of the Effect of Different Exercise Mode on Carotid Atherosclerosis.International journal of environmental research and public health · 2023
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61 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

Douglas R SealsDepartment of Integrative Physiology, University of Colorado Boulder, Boulder, CO, 80309, USA.
Erzsebet E NagyDepartment of Integrative Physiology, University of Colorado Boulder, Boulder, CO, 80309, USA.
Kerrie L MoreauDivision of Geriatric Medicine, Department of Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO, 80045, USA.
University of Colorado Boulder · USDenver VA Medical Center · US

Funding

ZOPOLRESTAT PHARMACOKINETICS IN DIABETICS WITH VARYING RENAL FUNCTIONM01RR000051 · NCRR · UNIVERSITY OF COLORADO DENVER · PI KRUGMAN, RICHARD D. · 1985 to 2008
$52.6M
Colorado Clinical and Translational Sciences InstituteUL1TR001082 · NCATS · UNIVERSITY OF COLORADO DENVER · PI SOKOL, RONALD J. · 2013 to 2017
$48.0M
University of Colorado Aging Training GrantT32AG000279 · NIA · UNIVERSITY OF COLORADO DENVER · PI Kerrie Moreau · 2001 to 2026
$10.1M
Weight Loss, Inflammation, and Vascular Endothelial Function in Older AdultsR01AG006537 · NIA · UNIVERSITY OF COLORADO AT BOULDER · PI SEALS, DOUGLAS R · 1986 to 2010
$4.4M
Testosterone Supplementation and Exercise in Elderly MenR01AG019339 · NIA · UNIVERSITY OF COLORADO DENVER · PI SCHWARTZ, ROBERT S · 2004 to 2008
$4.1M
SODIUM RESTRICTION &ARTERIAL COMPLIANCE IN OLDER HUMANSR01AG013038 · NIA · UNIVERSITY OF COLORADO AT BOULDER · PI SEALS, DOUGLAS R · 1996 to 2018
$4.0M
Cardiovascular Consequences of Hypogonadism in Men SupplementR01AG049762 · NIA · UNIVERSITY OF COLORADO DENVER · PI MOREAU, KERRIE · 2016 to 2020
$3.3M
Translational Studies of Age-Associated Arterial Dysfunction, Western Diet and Aerobic Exercise: Role of the Gut MicrobiomeR01HL134887 · NHLBI · UNIVERSITY OF COLORADO · PI SEALS, DOUGLAS R · 2017 to 2020
$3.1M
Human Aging, Exercise &FMD: Translational PhysiologyR37AG013038 · NIA · UNIVERSITY OF COLORADO AT BOULDER · PI SEALS, DOUGLAS R · 2004 to 2013
$3.0M
Aging and Arterial Dysfunction with a Western Diet: Exercise and AMPKR01HL107120 · NHLBI · UNIVERSITY OF COLORADO · PI SEALS, DOUGLAS R · 2011 to 2014
$1.6M
Biological Mechanisms of Arterial Stiffening With Age and Estrogen DeficiencyR01AG027678 · NIA · UNIVERSITY OF COLORADO DENVER · PI MOREAU, KERRIE · 2006 to 2010
$1.5M
Biological Mechanisms of Vascular Dysfunction with Age and Estrogen DeficiencyR56HL114073 · NHLBI · UNIVERSITY OF COLORADO DENVER · PI MOREAU, KERRIE · 2013 to 2013
$651k
NCATS NIH HHS UL1 TR001082NCRR NIH HHS M01 RR000051NHLBI NIH HHS R01 HL107120NHLBI NIH HHS R01 HL134887NHLBI NIH HHS R21 HL107105NHLBI NIH HHS R56 HL114073NIA NIH HHS K01 AG020683NIA NIH HHS R01 AG006537NIA NIH HHS R01 AG013038NIA NIH HHS R01 AG019339NIA NIH HHS R01 AG027678NIA NIH HHS R01 AG049762NIA NIH HHS R21 AG042795NIA NIH HHS R21 AG049451NIA NIH HHS R37 AG013038NIA NIH HHS T32 AG000279
6 · The paper itself

Abstract

Cardiovascular diseases (CVD) remain the leading cause of morbidity and mortality in both men and women in developed societies. Age is the greatest risk factor for CVD due largely to adverse changes to arteries that include stiffening of the large elastic arteries (aortic and carotid arteries) and endothelial dysfunction. Vascular ageing is driven by oxidative stress, which reduces nitric oxide (NO) bioavailability and stimulates changes in the extracellular matrix. In women, reductions in circulating oestrogens with menopause interact with ageing processes to induce vascular dysfunction. Regular aerobic exercise is the most evidence-based strategy for reducing CVD risk with ageing in both men and women. Much of this cardiovascular-protective effect of aerobic exercise is likely due to its vascular health-enhancing influence. Large elastic artery stiffening with advancing age is attenuated in healthy adults engaged in aerobic exercise training, and aerobic exercise interventions improve arterial stiffness in previously sedentary middle-aged and older men and postmenopausal women. Regular aerobic exercise also enhances endothelial function with ageing in men (by reducing oxidative stress and preserving NO bioavailability), but not consistently in oestrogen-deficient postmenopausal women. In postmenopausal women, treatment with oestradiol appears to restore the ability of aerobic exercise to improve NO-mediated endothelial function by reducing oxidative stress. Several research gaps exist in our understanding of potential sex differences in the vascular adaptations to regular aerobic exercise. More information is needed on the factors that are responsible for sex differences, including the role of circulating oestrogens in transducing the aerobic exercise training 'stimulus'.

Indexed as

Cardiovascular Physiological PhenomenaAgingExerciseFemaleHumansMaleOxidative Stressarterial stiffnessendothelial functionestrogenoxidative stress

Identifiers

PMID31077372
PMCPMC6773490
OpenAlexW2943953309

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.