ArticleThe Plant journal : for cell and molecular biology2019
Multiple downy mildew effectors target the stress-related NAC transcription factor LsNAC069 in lettuce.
Article in The Plant journal : for cell and molecular biology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 57 citations in OpenAlex.
- Targeting of the Hybrid Bamboo BDDnaJ by Pathogen Effector ApcE12 Regulates the Unfolded Protein Response.Molecular plant pathology · 2025Article
- A catalogue of virulence strategies mediated by phytopathogenic effectors.Fundamental research · 2025Review
- Decoding Plant-Pathogen Interactions: A Comprehensive Exploration of Effector-Plant Transcription Factor Dynamics.Molecular plant pathology · 2025Review
- Pinus radiata cDNA Library for the Screening of Phytophthora Effector Protein Targets in Yeast.Methods in molecular biology (Clifton, N.J.) · 2025Article
- Plant NAC transcription factors in the battle against pathogens.BMC plant biology · 2024Review
- A conserved oomycete effector RxLR23 triggers plant defense responses by targeting ERD15La to release NbNAC68.Nature communications · 2024Article
- A tell tail sign: a conserved C-terminal tail-anchor domain targets a subset of pathogen effectors to the plant endoplasmic reticulum.Journal of experimental botany · 2023Article
- The Role of Plant Transcription Factors in the Fight against Plant Viruses.International journal of molecular sciences · 2023Review
- Proteolytic Activation of Plant Membrane-Bound Transcription Factors.Frontiers in plant science · 2022Review
- Exploiting Structural Modelling Tools to Explore Host-Translocated Effector Proteins.International journal of molecular sciences · 2021Review
- The NAC side of the fruit: tuning of fruit development and maturation.BMC plant biology · 2021Review
- Interior design: how plant pathogens optimize their living conditions.The New phytologist · 2021Review
- Endomembrane-TargetingFrontiers in microbiology · 2021Article
- NAC Transcription Factors as Positive or Negative Regulators during Ongoing Battle between Pathogens and Our Food Crops.International journal of molecular sciences · 2020Review
- Transcriptome analysis reveals underlying immune response mechanism of fungal (Penicillium oxalicum) disease in Gastrodia elata Bl. f. glauca S. chow (Orchidaceae).BMC plant biology · 2020Article
- All Roads Lead to Susceptibility: The Many Modes of Action of Fungal and Oomycete Intracellular Effectors.Plant communications · 2020Review
- Transcription Factors in Plant Stress Responses: Challenges and Potential for Sugarcane Improvement.Plants (Basel, Switzerland) · 2020Review
- Host interactors of effector proteins of the lettuce downy mildew Bremia lactucae obtained by yeast two-hybrid screening.PloS one · 2020Article
- Genome reconstruction of the non-culturable spinach downy mildew Peronospora effusa by metagenome filtering.PloS one · 2020Article
- Transcription Factor Networks in Leaves ofPlants (Basel, Switzerland) · 2019Article
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
To cause disease in lettuce, the biotrophic oomycete Bremia lactucae secretes potential RxLR effector proteins. Here we report the discovery of an effector-target hub consisting of four B. lactucae effectors and one lettuce protein target by a yeast-two-hybrid (Y2H) screening. Interaction of the lettuce tail-anchored NAC transcription factor, LsNAC069, with B. lactucae effectors does not require the N-terminal NAC domain but depends on the C-terminal region including the transmembrane domain. Furthermore, in Y2H experiments, B. lactucae effectors interact with Arabidopsis and potato tail-anchored NACs, suggesting that they are conserved effector targets. Transient expression of RxLR effector proteins BLR05 and BLR09 and their target LsNAC069 in planta revealed a predominant localization to the endoplasmic reticulum. Phytophthora capsici culture filtrate and polyethylene glycol treatment induced relocalization to the nucleus of a stabilized LsNAC069 protein, lacking the NAC-domain (LsNAC069
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.