Evidence map›Paper›PMID 31078653›Full record

ArticleReproductive toxicology (Elmsford, N.Y.)2019

Gestational binge alcohol-induced alterations in maternal uterine artery transcriptome.

Marcus R Orzabal, Emilie R Lunde-Young, Josue I Ramirez, Vishal D Naik, Andrew Hillhouse, Kranti Konganti, David W Threadgill, Jayanth Ramadoss

Open access · greenAbstract read
In one paragraph

Article in Reproductive toxicology (Elmsford, N.Y.), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.4field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Marcus R OrzabalDepartment of Veterinary Physiology and Pharmacology, College of Veterinary Medicine and Biomedical Sciences, Texas A&M University, College Station, TX, USA.
Emilie R Lunde-YoungDepartment of Veterinary Physiology and Pharmacology, College of Veterinary Medicine and Biomedical Sciences, Texas A&M University, College Station, TX, USA.
Josue I RamirezDepartment of Veterinary Physiology and Pharmacology, College of Veterinary Medicine and Biomedical Sciences, Texas A&M University, College Station, TX, USA.
Vishal D NaikDepartment of Veterinary Physiology and Pharmacology, College of Veterinary Medicine and Biomedical Sciences, Texas A&M University, College Station, TX, USA.
Andrew HillhouseDepartment of Veterinary Pathobiology, College of Veterinary Medicine and Biomedical Sciences, Texas A&M University, College Station, and the Texas A&M Institute of Genome Sciences, TX, USA.
Kranti KongantiDepartment of Veterinary Pathobiology, College of Veterinary Medicine and Biomedical Sciences, Texas A&M University, College Station, and the Texas A&M Institute of Genome Sciences, TX, USA.
David W ThreadgillDepartment of Veterinary Pathobiology, College of Veterinary Medicine and Biomedical Sciences, Texas A&M University, College Station, and the Texas A&M Institute of Genome Sciences, TX, USA.
Jayanth RamadossDepartment of Veterinary Physiology and Pharmacology, College of Veterinary Medicine and Biomedical Sciences, Texas A&M University, College Station, TX, USA. Electronic address: jramadoss@cvm.tamu.edu.
Texas A&M University · US

Funding

A Novel Mechanistic Framework for FASD Etiology.R01AA023520 · NIAAA · WAYNE STATE UNIVERSITY · PI RAMADOSS, JAYANTH · 2015 to 2024
$3.5M
Maternal Uterine Vascular Origins of Fetal Alcohol Spectrum DisordersR00AA019446 · NIAAA · UNIVERSITY OF TEXAS MED BR GALVESTON · PI RAMADOSS, JAYANTH · 2011 to 2013
$730k
A Novel Platform for Maternal Alcohol Consumption ScreeningR21AA023035 · NIAAA · TEXAS A&M AGRILIFE RESEARCH · PI RAMADOSS, JAYANTH · 2015 to 2016
$421k
Maternal Uterine Vascular Origins of Fetal Alcohol Spectrum DisordersK99AA019446 · NIAAA · UNIVERSITY OF WISCONSIN-MADISON · PI RAMADOSS, JAYANTH · 2010 to 2011
$267k
NIAAA NIH HHS K99 AA019446NIAAA NIH HHS R00 AA019446NIAAA NIH HHS R01 AA023520NIAAA NIH HHS R21 AA023035
6 · The paper itself

Abstract

Binge alcohol exposure during pregnancy results in diminished vessel function and altered proteome in the maternal uterine artery. We aimed to utilize high throughput RNA-seq deep-sequencing to characterize specific effects of binge alcohol exposure during pregnancy on the uterine artery transcriptome, and gain insight into mechanisms underlying alcohol-mediated uterine artery dysfunction. Pregnant Sprague-Dawley rats assigned to Pair-Fed Control or Alcohol groups, received a once-daily orogastric gavage in a binge paradigm. RNA-sequencing using Illumina NextSeq 500, identified 13,941 genes; 40 significantly altered genes were altered by log

Indexed as

AnimalsBinge DrinkingEthanolFemalePregnancyRats, Sprague-DawleyRNA-SeqTranscriptomeUterine ArteryEthanolAlcoholEndothelialTeratology

Identifiers

PMID31078653
PMCPMC6628922
OpenAlexW2944730625

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.