Evidence map›Paper›PMID 31084567›Full record

ReviewMolecular biology of the cell2019

ARF GTPases and their GEFs and GAPs: concepts and challenges.

Elizabeth Sztul, Pei-Wen Chen, James E Casanova, Jacqueline Cherfils, Joel B Dacks, David G Lambright, Fang-Jen S Lee, Paul A Randazzo, Lorraine C Santy, Annette Schürmann and 3 more

Open access · greenAbstract readReview
In one paragraph

Review in Molecular biology of the cell, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 157 papers.

0numbers the graph read from it
0cells of the map it votes in
157citing papers in PubMed
11.8field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

157 citing papers in PubMed, 264 citations in OpenAlex.

  1. Article
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  3. Review
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  8. Review
  9. ARF GTPases Function at the Golgi.Sub-cellular biochemistry · 2026
    Review
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  12. Review
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97 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 11 institutions in 5 countries.

Elizabeth SztulDepartment of Cell, Developmental and Integrative Biology, University of Alabama at Birmingham, Birmingham, AL 35294.
Pei-Wen ChenDepartment of Biology, Williams College, Williamstown, MA 01267.
James E CasanovaDepartment of Cell Biology, University of Virginia, Charlottesville, VA 22908.
Jacqueline CherfilsLaboratoire de Biologie et Pharmacologie Appliquée, CNRS and Ecole Normale Supérieure Paris-Saclay, 94235 Cachan, France.
Joel B DacksDivision of Infectious Disease, Department of Medicine, University of Alberta, Edmonton, AB T6G 2H7, Canada.
David G LambrightProgram in Molecular Medicine and Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, Amherst, MA 01605.
Fang-Jen S LeeInstitute of Molecular Medicine, College of Medicine, National Taiwan University, Taipei 10002, Taiwan.
Paul A RandazzoLaboratory of Cellular and Molecular Biology and.
Lorraine C SantyDepartment of Biochemistry and Molecular Biology, Pennsylvania State University, University Park, PA 16802.
Annette SchürmannGerman Institute of Human Nutrition, 85764 Potsdam-Rehbrücke, Germany.
Ilka WilhelmiGerman Institute of Human Nutrition, 85764 Potsdam-Rehbrücke, Germany.
Marielle E YohePediatric Oncology Branch, Center for Cancer Research, National Cancer Institute, Bethesda, MD 20892.
Richard A KahnDepartment of Biochemistry, Emory University School of Medicine, Atlanta, GA 30322-3050.
German Institute of Human Nutrition · DECentre National de la Recherche Scientifique · FREmory University · USNational Cancer Institute · USNational Taiwan University · TWPennsylvania State University · USUniversity of Alabama at Birmingham · USUniversity of Alberta · CAUniversity of Massachusetts Amherst · USUniversity of Virginia · USWilliams College · US

Funding

STRUCTURAL BASIS OF G PROTEIN MEDIATED SIGNALINGR01GM056324 · NIGMS · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI LAMBRIGHT, DAVID G · 1998 to 2018
$6.2M
Molecular mechanisms of ARF family GTPasesR35GM122568 · NIGMS · EMORY UNIVERSITY · PI KAHN, RICHARD A · 2017 to 2024
$3.7M
REGULATION OF ADP-RIBOSYLATION FACTORZ01BC007365 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI RANDAZZO, PAUL A · 1996 to 2008
$3.3M
The Regulation and Cellular Activities of the ARL2 GTPaseR01GM090158 · NIGMS · EMORY UNIVERSITY · PI KAHN, RICHARD A · 2010 to 2017
$2.5M
Targeting RAS in Pediatric CancerZIABC011892 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI YOHE, MARIELLE · 2019 to 2025
$2.3M
Spatio-temporal regulation of ARF signaling in vesicle formationR01GM122802 · NIGMS · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI SZTUL, ELIZABETH S · 2017 to 2020
$1.5M
Cytohesin dependent ARF to Rac signaling in HGF mediated motilityR01DK093729 · NIDDK · PENNSYLVANIA STATE UNIVERSITY, THE · PI SANTY, LORRAINE C · 2012 to 2016
$1.4M
Role of ARF5 and ER/plasma membrane contacts in the control of cell migrationR01GM127361 · NIGMS · UNIVERSITY OF VIRGINIA · PI CASANOVA, JAMES E. · 2019 to 2022
$1.4M
Intramural NIH HHS Z01 BC007365NIDDK NIH HHS R01 DK093729NIGMS NIH HHS R01 GM056324NIGMS NIH HHS R01 GM122802NIGMS NIH HHS R01 GM127361NIGMS NIH HHS R35 GM122568
6 · The paper itself

Abstract

Detailed structural, biochemical, cell biological, and genetic studies of any gene/protein are required to develop models of its actions in cells. Studying a protein family in the aggregate yields additional information, as one can include analyses of their coevolution, acquisition or loss of functionalities, structural pliability, and the emergence of shared or variations in molecular mechanisms. An even richer understanding of cell biology can be achieved through evaluating functionally linked protein families. In this review, we summarize current knowledge of

Indexed as

Signal TransductionAnimalsEukaryotaGTPase-Activating ProteinsGuanine Nucleotide Exchange FactorsHumansGTPase-Activating ProteinsGuanine Nucleotide Exchange Factors

Identifiers

PMID31084567
PMCPMC6724607
OpenAlexW2945832809

What Socratic holds

Textmetadata
LicenceCC BY-NC-SA
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.