ArticleAmerican journal of physiology. Renal physiology2019
Knockout of Na
Open access · bronzeAbstract readComparative Study
In one paragraph
Article in American journal of physiology. Renal physiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 47 papers.
0numbers the graph read from it
0cells of the map it votes in
47citing papers in PubMed
5.1field-weighted citation impact, top 4% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
47 citing papers in PubMed, 60 citations in OpenAlex.
- SGLT2 gene expression in thirst-promoting NOS1 neurons and vasopressin-synthesizing neurons in male rats.Physiological reports · 2026Article
- Transcriptomics of S3 segment in mice: response to type 1 diabetes, SGLT1/2 inhibition, or GLP1 receptor agonism.American journal of physiology. Renal physiology · 2026Article
- Life-Course Regulation of Health and Disease by Nitric Oxide: Mechanistic Insights.Antioxidants (Basel, Switzerland) · 2026Review
- Glomerular hyperfiltration and enhanced sensitivity to kidney ischemia reperfusion with a blunted KIM-1 response in young male aging-accelerated SAMP8 mice.American journal of physiology. Renal physiology · 2026Article
- Sodium-Glucose Cotransporter 2 Inhibitors in Autosomal Dominant Polycystic Kidney Disease: Mechanistic Insights and Therapeutic Promise.Journal of the American Society of Nephrology : JASN · 2026Review
- New potential therapeutic targets of metabolic disorder-associated kidney disease and diabetic kidney disease.Kidney international · 2026Review
- Assessment, molecular mechanisms and therapeutic targets for renal functional reserve.Renal failure · 2025Review
- ASK1 limits kidney glucose reabsorption, growth, and mid-late proximal tubule KIM-1 induction when diabetes and Western diet are combined with SGLT2 inhibition.American journal of physiology. Renal physiology · 2025Article
- Effects of sotagliflozin on kidney and cardiac outcome in a hypertensive model of subtotal nephrectomy in male mice.Physiological reports · 2025Article
- Transcriptomics of SGLT2-positive early proximal tubule segments in mice: response to type 1 diabetes, SGLT1/2 inhibition, or GLP1 receptor agonism.American journal of physiology. Renal physiology · 2025Article
- Oxidative Stress in Kidney Injury and Hypertension.Antioxidants (Basel, Switzerland) · 2024Review
- State-of-the-Art-Review: Mechanisms of Action of SGLT2 Inhibitors and Clinical Implications.American journal of hypertension · 2024Review
- How can inhibition of glucose and sodium transport in the early proximal tubule protect the cardiorenal system?Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association · 2024Review
- Proximal tubule hypertrophy and hyperfunction: a novel pathophysiological feature in disease states.Clinical kidney journal · 2024Review
- Physiological Mechanisms of Dietary Salt Sensing in the Brain, Kidney, and Gastrointestinal Tract.Hypertension (Dallas, Tex. : 1979) · 2024Review
- SGLT2 and SGLT1 inhibitors suppress the activities of the RVLM neurons in newborn Wistar rats.Hypertension research : official journal of the Japanese Society of Hypertension · 2024Article
- Early use of SGLT2 inhibitors reduces the progression of diabetic kidney disease: a retrospective cohort study.American journal of translational research · 2024Article
- Deletion, but Not Heterozygosity, of eNOS Raises Blood Pressure and Aggravates Nephropathy in BTBR ob/ob Mice.Nephron · 2024Article
- Modeling the renoprotective mechanisms of SGLT2 inhibition in hypertensive chronic kidney disease.Physiological reports · 2023Article
- Functional and Clinical Importance of SGLT2-inhibitors in Frailty: From the Kidney to the Heart.Hypertension (Dallas, Tex. : 1979) · 2023Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
12 authors at 4 institutions in 2 countries.
Panai SongDivision of Nephrology, Department of Medicine, University of California-San Diego , La Jolla, California.
Winnie HuangVeterans Affairs San Diego Healthcare System, San Diego, California.
Akira OnishiDivision of Nephrology, Department of Medicine, University of California-San Diego , La Jolla, California.
Rohit PatelVeterans Affairs San Diego Healthcare System, San Diego, California.
Young Chul KimDivision of Nephrology, Department of Medicine, University of California-San Diego , La Jolla, California.
Charlotte van GinkelDivision of Nephrology, Department of Medicine, University of California-San Diego , La Jolla, California.
Yiling FuVeterans Affairs San Diego Healthcare System, San Diego, California.
Brent FreemanVeterans Affairs San Diego Healthcare System, San Diego, California.
Hermann KoepsellInstitute for Anatomy and Cell Biology, University of Würzburg , Würzburg , Germany.
Scott ThomsonDivision of Nephrology, Department of Medicine, University of California-San Diego , La Jolla, California.
Ruisheng LiuDepartment of Molecular Pharmacology and Physiology, University of South Florida College of Medicine , Tampa, Florida.
Volker VallonDivision of Nephrology, Department of Medicine, University of California-San Diego , La Jolla, California.
VA San Diego Healthcare System · USUniversity of California, San Diego · USUniversity of South Florida · USUniversity of Würzburg · DE
Funding
UAB-UCSD O'Brien Core Center for Acute Kidney Injury ResearchP30DK079337 · NIDDK · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI AGARWAL, ANUPAM · 2008 to 2022
$18.3MGlomerular and Tubular Function in the Diabetic KidneyR01DK112042 · NIDDK · VETERANS MEDICAL RESEARCH FDN/SAN DIEGO · PI SCOTT Culver THOMSON, Volker Vallon · 2017 to 2026
$4.1MRole of tubuloglomerular feedback in the development of hypertension in diabetesR01HL142814 · NHLBI · UNIVERSITY OF SOUTH FLORIDA · PI LIU, RUISHENG · 2019 to 2022
$2.4MRenal hemodynamics and hypertension during pregnancyR01HL137987 · NHLBI · UNIVERSITY OF SOUTH FLORIDA · PI LIU, RUISHENG · 2018 to 2021
$1.6MUnraveling Kidney Physiology, Pathophysiology & Therapeutics: A Modeling ApproachR01DK106102 · NIDDK · DUKE UNIVERSITY · PI LAYTON, ANITA · 2016 to 2019
$1.4MPrimary cilia and modulation of the renal microcirculationR01DK099276 · NIDDK · UNIVERSITY OF SOUTH FLORIDA · PI LIU, RUISHENG · 2014 to 2017
$980kNHLBI NIH HHS R01 HL137987NHLBI NIH HHS R01 HL142814NIDDK NIH HHS P30 DK079337NIDDK NIH HHS R01 DK099276NIDDK NIH HHS R01 DK106102NIDDK NIH HHS R01 DK112042
Abstract
Na
Indexed as
Glomerular Filtration RateAlbuminuriaAnimalsBiomarkersBlood GlucoseBlood PressureDiabetes Mellitus, ExperimentalDiabetes Mellitus, Type 1Diabetic NephropathiesKidneyMice, Inbred C57BLMice, Inbred DBAMice, KnockoutNitric Oxide Synthase Type IRenal ReabsorptionReninBiomarkersBlood GlucoseNitric Oxide Synthase Type INos1 protein, mouseReninSlc5a1 protein, mouseSlc5a2 protein, mouseSodium-Glucose Transporter 1Sodium-Glucose Transporter 2Sodium-Glucose Transporter 2 Inhibitorsdiabetes mellitusglomerular hyperfiltrationhypertensionNa-glucose cotransporter 2neuronal nitric oxide synthase
Identifiers
What Socratic holds
Textmetadata
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.