Evidence map›Paper›PMID 31095089›Full record

SynthesisMedicine and science in sports and exercise2019

Effects of Physical Activity in Knee and Hip Osteoarthritis: A Systematic Umbrella Review.

Virginia B Kraus, Kyle Sprow, Kenneth E Powell, David Buchner, Bonny Bloodgood, Katrina Piercy, Stephanie M George, William E Kraus, 2018 PHYSICAL ACTIVITY GUIDELINES ADVISORY COMMITTEE*

Registry-linked trialOpen access · greenAbstract readSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Medicine and science in sports and exercise, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05152758 (STABILITY), which is not on this map. Cited by 121 papers, 10 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
121citing papers in PubMed, 10 pooled it
15.7field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05152758 naactive not recruitingnot on this mapstarted 2021, after this paper: background citation

STABILITY: Physical Activity Intervention at 7 Years Post-Anterior Cruciate Ligament Reconstruction

TypeinterventionalSponsorWestern University, CanadaRan2021 to 2025Enrolled196ConditionsAnterior Cruciate Ligament Reconstruction, Post-traumatic OsteoarthritisArmsPARx
3 · Its place in the literature

Who cites it

121 citing papers in PubMed, 10 syntheses or guidelines pooled it, 233 citations in OpenAlex.

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61 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 7 institutions in 1 country.

Virginia B KrausDuke Molecular Physiology Institute, Department of Medicine, Duke University School of Medicine, Durham, NC.
Kyle SprowNational Cancer Institute, National Institutes of Health, U.S. Department of Health and Human Services, Bethesda, MD.
Kenneth E PowellGeorgia Department of Human Resources, Centers for Disease Control and Prevention (Retired), Atlanta, GA.
David BuchnerDepartment of Kinesiology and Community Health University of Illinois at Urbana-Champaign, Champaign, IL.
Bonny BloodgoodICF, Fairfax, VA.
Katrina PiercyOffice of Disease Prevention and Health Promotion, U.S. Department of Health and Human Services, Rockville, MD.
Stephanie M GeorgeOffice of Disease Prevention, National Institutes of Health, U.S Department of Health and Human Services, Rockville, MD.
William E KrausDuke Molecular Physiology Institute, Department of Medicine, Duke University School of Medicine, Durham, NC.
2018 PHYSICAL ACTIVITY GUIDELINES ADVISORY COMMITTEE*
Duke University · USCenters for Disease Control and Prevention · USICF International (United States) · USNational Cancer Institute · USNational Institutes of Health · USOffice of Disease Prevention and Health Promotion · USUniversity of Illinois Urbana-Champaign · US

Funding

Intramural NIH HHS Z99 OD999999
6 · The paper itself

Abstract

introductionWe conducted a systematic umbrella review to evaluate the literature relating to effects of physical activity on pain, physical function, health-related quality of life, comorbid conditions and osteoarthritis (OA) structural disease progression in individuals with lower-extremity OA.

methodsOur primary search encompassed 2011 to February 2018 for existing systematic reviews (SR), meta-analyses (MA) and pooled analyses dealing with physical activity including exercise (not mixed with any other intervention and compared to a no-activity control group). A supplementary search encompassed 2006 to February 2018 for original research related to physical activity (including exercise) and lower limb OA progression. Study characteristics were abstracted, and risk of bias was assessed.

resultsPhysical activity decreased pain and improved physical function (strong evidence) and improved health-related quality of life (moderate evidence) among people with hip or knee OA relative to less active adults with OA. There was no evidence to suggest accelerated OA progression for physical activity below 10,000 steps per day. Both physical activity equivalent to the 2008 Physical Activity Guidelines for Americans (150 min·wk of moderate-intensity exercise in bouts ≥10 min) and lower levels of physical activity (at least 45 total minutes per week of moderate-intensity) were associated with improved or sustained high function. No SR/MA addressing comorbid conditions in OA were found. Measurable benefits of physical activity appeared to persist for periods of up to 6 months following cessation of a defined program.

conclusionsPeople with lower-extremity OA should be encouraged to engage in achievable amounts of physical activity, of even modest intensities. They can choose to accrue minutes of physical activity throughout the entire day, irrespective of bout duration, and be confident in gaining some health and arthritis-related benefits.

Indexed as

ExerciseQuality of LifeBiomedical ResearchComorbidityDisease ProgressionHumansOsteoarthritis, HipOsteoarthritis, KneePainPractice Guidelines as Topic

Identifiers

PMID31095089
PMCPMC6527143
OpenAlexW2944864417

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.