Trial reportJournal of the American Society of Nephrology : JASN2019
The Primary-Secondary Care Partnership to Improve Outcomes in Chronic Kidney Disease (PSP-CKD) Study: A Cluster Randomized Trial in Primary Care.
Trial report in Journal of the American Society of Nephrology : JASN, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. It is linked to trial NCT01688141 (A Primary-Secondary Care Partnership to Prevent Adverse Outcomes in Chronic Kidney Disease), which is not on this map. Cited by 19 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
A Primary-Secondary Care Partnership to Prevent Adverse Outcomes in Chronic Kidney Disease
Who cites it
19 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Challenges and strategies for managing early-to-moderate chronic kidney disease in primary care: A systematic integrative review in high-income countries.The European journal of general practice · 2026Pooled it
- Effectiveness of Multicomponent Interventions in Slowing Progression of CKD Stages G3-G4: A Systematic Review and Meta-Analysis.Clinical journal of the American Society of Nephrology : CJASN · 2026Pooled it
- Electronic Decision Support for Management of CKD in Primary Care: A Pragmatic Randomized Trial.American journal of kidney diseases : the official journal of the National Kidney Foundation · 2020Trial
- Care Processes and Clinical Responses to Newly Detected Albuminuria: The Stockholm Creatinine Measurements (SCREAM) Project.American journal of kidney diseases : the official journal of the National Kidney Foundation · 2026Article
- Expanding Kidney Care: How Nonphysician Health Workers Can Address the Global CKD Crisis.Kidney international reports · 2026Review
- Implementing a model of integrated CKD management between primary and secondary care.Clinical kidney journal · 2026Review
- Integrated primary and secondary care optimizes the management of people with CKD-the LUCID project.Clinical kidney journal · 2025Article
- Obstacles and Opportunities for Albuminuria Testing On the Basis of the Perspective of Primary Care: A Qualitative Study.Clinical journal of the American Society of Nephrology : CJASN · 2025Article
- Chronic kidney disease management in primary care: challenges and possible developments.The British journal of general practice : the journal of the Royal College of General Practitioners · 2025Article
- The impact of nurse-led care in chronic kidney disease management: a systematic review and meta-analysis.BMC nursing · 2025Article
- Rethinking Models of Chronic Kidney Disease Care: A Narrative Review.Kidney & blood pressure research · 2025Review
- Article
- Impacting Management of Chronic Kidney Disease Through Primary Care Practice Audits: A Quality Improvement Study.Canadian journal of kidney health and disease · 2022Article
- Referring patients with chronic kidney disease back to primary care: a criteria-based analysis in outpatient renal clinics.BMC nephrology · 2021Article
- Tackling Dialysis Burden around the World: A Global Challenge.Kidney diseases (Basel, Switzerland) · 2021Article
- Article
- CKD Management in Primary Care: Supporting Systems Change.American journal of kidney diseases : the official journal of the National Kidney Foundation · 2020Article
- Article
- Mixed-effects models for health care longitudinal data with an informative visiting process: A Monte Carlo simulation study.Statistica Neerlandica · 2020Article
Corrections and comments
- Erratum issued
Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundMost patients with CKD are managed in the community. Whether nurse-led CKD management programs improve outcomes in patients with CKD in primary care is unclear.
methodsTo assess the effect of such a program on the rate of renal function decline in patients with CKD (stages 3-5) in primary care in the United Kingdom, we conducted a cluster randomized trial, the Primary-Secondary Care Partnership to Improve Outcomes in Chronic Kidney Disease study. A software program designed for the study created a data file of patients with CKD in participating practices. In 23 intervention practices (11,651 patients), a CKD nurse practitioner worked with nominated practice leads to interpret the data file and implement guideline-based patient-level CKD management interventions. The 23 control practices (11,706 patients) received a data file but otherwise, continued usual CKD care. The primary outcome was defined at the cluster (practice) level as the change from baseline of the mean eGFR of the patients with CKD at 6-month intervals up to 42 months. Secondary outcomes included numbers of patients coded for CKD, mean BP, numbers of patients achieving National Institute for Health and Care Excellence BP targets for CKD, and proteinuria measurement.
resultsAfter 42 months, eGFR did not differ significantly between control and intervention groups. CKD- and proteinuria-related coding improved significantly along with the number of patients achieving BP targets in the intervention group versus usual care.
conclusionsCKD management programs in primary care may not slow progression of CKD, but they may significantly improve processes of care and potentially decrease the cardiovascular disease burden in CKD and related costs.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.