Evidence map›Paper›PMID 31098406›Full record

ArticleCommunications biology2019

Caffeine-free hawk tea lowers cholesterol by reducing free cholesterol uptake and the production of very-low-density lipoprotein.

Juan Feng, Jian Yang, Yujun Chang, Liansheng Qiao, Honglei Dang, Kun Luo, Hongyan Guo, Yannan An, Chengmei Ma, Hong Shao and 5 more

Open access · goldAbstract read
In one paragraph

Article in Communications biology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
4.2field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 36 citations in OpenAlex.

  1. Processing-Induced Metabolic Reprogramming ofFood science & nutrition · 2026
    Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Complete chloroplast genome sequence of a subtropical tree,Mitochondrial DNA. Part B, Resources · 2022
    Article
  13. The complete chloroplast genome sequence ofMitochondrial DNA. Part B, Resources · 2022
    Article
  14. Article
  15. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 2 institutions in 1 country.

Juan Feng *1State Key Laboratory of Membrane Biology, School of Medicine, Tsinghua University, 100084 Beijing, China.
Jian Yang *4State Key Laboratory Breeding Base of Dao-di Herbs, National Resource Center for Chinese Materia Medica, China Academy of Chinese Medical Sciences, 100700 Beijing, China.
Yujun ChangNational Engineering Research Center for Beijing Biochip Technology, 102206 Beijing, China.
Liansheng Qiao1State Key Laboratory of Membrane Biology, School of Medicine, Tsinghua University, 100084 Beijing, China.
Honglei DangNational Engineering Research Center for Beijing Biochip Technology, 102206 Beijing, China.
Kun Luo1State Key Laboratory of Membrane Biology, School of Medicine, Tsinghua University, 100084 Beijing, China.
Hongyan GuoNational Engineering Research Center for Beijing Biochip Technology, 102206 Beijing, China.
Yannan AnNational Engineering Research Center for Beijing Biochip Technology, 102206 Beijing, China.
Chengmei MaNational Engineering Research Center for Beijing Biochip Technology, 102206 Beijing, China.
Hong ShaoNational Engineering Research Center for Beijing Biochip Technology, 102206 Beijing, China.
Jie TianNational Engineering Research Center for Beijing Biochip Technology, 102206 Beijing, China.
Yuan Yuan4State Key Laboratory Breeding Base of Dao-di Herbs, National Resource Center for Chinese Materia Medica, China Academy of Chinese Medical Sciences, 100700 Beijing, China.
Lan Xie1State Key Laboratory of Membrane Biology, School of Medicine, Tsinghua University, 100084 Beijing, China.
Wanli Xing1State Key Laboratory of Membrane Biology, School of Medicine, Tsinghua University, 100084 Beijing, China.
Jing Cheng1State Key Laboratory of Membrane Biology, School of Medicine, Tsinghua University, 100084 Beijing, China.
Tsinghua University · CNChinese Academy of Medical Sciences & Peking Union Medical College · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Medicinal plants show important therapeutic value in chronic disease treatment. However, due to their diverse ingredients and complex biological effects, the molecular mechanisms of medicinal plants are yet to be explored. By means of several high-throughput platforms, here we show hawk tea extract (HTE) inhibits Niemann-Pick C1-like 1 (NPC1L1)-mediated free cholesterol uptake, thereby inducing the transcription of low-density lipoprotein receptor (

Indexed as

LitseaTeas, MedicinalAnimalsAnticholesteremic AgentsBiological Transport, ActiveCaffeineCatechinCholesterolDisease Models, AnimalDyslipidemiasFeeder CellsGastrointestinal MicrobiomeHep G2 CellsHumansKaempferolsLipid MetabolismAnticholesteremic AgentsCaffeineCatechinCholesterolepigallocatechin gallatekaempferolKaempferolsLipoproteins, VLDLQuercetinReceptors, LDLSterol Regulatory Element Binding Protein 2Gene expression analysisMetabolic disordersTarget identification

Identifiers

PMID31098406
PMCPMC6506518
OpenAlexW2944377515

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.