Evidence map›Paper›PMID 31100191›Full record

ArticleJournal of biophotonics2019

Automatic skin lesion area determination of basal cell carcinoma using optical coherence tomography angiography and a skeletonization approach: Preliminary results.

Kristen M Meiburger, Zhe Chen, Christoph Sinz, Erich Hoover, Michael Minneman, Jason Ensher, Harald Kittler, Rainer A Leitgeb, Wolfgang Drexler, Mengyang Liu

Open access · hybridAbstract readValidation Study
In one paragraph

Article in Journal of biophotonics, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
1.7field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 32 citations in OpenAlex.

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  12. Optical coherence tomography.Nature reviews. Methods primers · 2022
    Article
  13. Techniques for Imaging Vascular Supply of Peripheral Nerves.Journal of brachial plexus and peripheral nerve injury · 2021
    Review
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  16. What scans we will read: imaging instrumentation trends in clinical oncology.Cancer imaging : the official publication of the International Cancer Imaging Society · 2020
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 3 countries.

Kristen M MeiburgerBiolab, Department of Electronics and Telecommunications, Politecnico di Torino, Torino, Italy.ORCID 0000-0002-7302-6135
Zhe ChenCenter for Medical Physics and Biomedical Engineering, Medical University of Vienna, Vienna, Austria.
Christoph SinzDepartment of Dermatology, Medical University of Vienna, Vienna, Austria.ORCID 0000-0001-5589-1865
Erich HooverInsight Photonic Solutions, Inc., Lafayette, CO.
Michael MinnemanInsight Photonic Solutions, Inc., Lafayette, CO.
Jason EnsherInsight Photonic Solutions, Inc., Lafayette, CO.
Harald KittlerDepartment of Dermatology, Medical University of Vienna, Vienna, Austria.ORCID 0000-0002-0051-8016
Rainer A LeitgebCenter for Medical Physics and Biomedical Engineering, Medical University of Vienna, Vienna, Austria.ORCID 0000-0002-0131-4111
Wolfgang DrexlerCenter for Medical Physics and Biomedical Engineering, Medical University of Vienna, Vienna, Austria.
Mengyang LiuCenter for Medical Physics and Biomedical Engineering, Medical University of Vienna, Vienna, Austria.ORCID 0000-0002-8862-5966
Medical University of Vienna · ATPhotonic Systems (United States) · USPolitecnico di Torino · IT

Funding

Austrian Research Fund FWF P26687-N25Austrian Science Fund P26687-N25European Union Seventh Framework Programme (FP7) Information and Communication Technologies (ICT) FAMOS 317744Horizon 2020 Framework Programme ESOTRAC 732720
6 · The paper itself

Abstract

Cutaneous blood flow plays a key role in numerous physiological and pathological processes and has significant potential to be used as a biomarker to diagnose skin diseases such as basal cell carcinoma (BCC). The determination of the lesion area and vascular parameters within it, such as vessel density, is essential for diagnosis, surgical treatment and follow-up procedures. Here, an automatic skin lesion area determination algorithm based on optical coherence tomography angiography (OCTA) images is presented for the first time. The blood vessels are segmented within the OCTA images and then skeletonized. Subsequently, the skeleton is searched over the volume and numerous quantitative vascular parameters are calculated. The vascular density is then used to segment the lesion area. The algorithm is tested on both nodular and superficial BCC, and comparing with dermatological and histological results, the proposed method provides an accurate, non-invasive, quantitative and automatic tool for BCC lesion area determination.

Indexed as

AdultAgedAlgorithmsAngiographyBasal Cell CarcinomaBlood VesselsDiagnosis, Computer-AssistedEquipment DesignFemaleHumansImage Interpretation, Computer-AssistedImaging, Three-DimensionalMaleMiddle AgedSkin NeoplasmsTomography, Optical Coherencebasal cell carcinomacomputer-aided detectionoptical coherence tomography angiographyquantificationskeletonization

Identifiers

PMID31100191
PMCPMC7065618
OpenAlexW2945681174

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.