Evidence map›Paper›PMID 31101663›Full record

ArticleDisease models & mechanisms2019

Loss of function of

Krista A Geister, Alberto Jose Lopez-Jimenez, Scott Houghtaling, Tzu-Hua Ho, Roberto Vanacore, David R Beier

Open access · goldAbstract read
In one paragraph

Article in Disease models & mechanisms, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
1.4field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 33 citations in OpenAlex.

  1. Article
  2. The life cycle of type IV collagen.Matrix biology : journal of the International Society for Matrix Biology · 2025
    Review
  3. Article
  4. Article
  5. Article
  6. Skeletal pathology in mouse models of Gould syndrome is partially alleviated by genetically reducing TGFβ signaling.Matrix biology : journal of the International Society for Matrix Biology · 2024
    Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Morphological and Molecular Responses ofInternational journal of molecular sciences · 2022
    Article
  12. Article
  13. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Krista A GeisterCenter for Developmental Biology and Regenerative Medicine, Seattle Children's Research Institute, Seattle,  WA 98105, USA.
Alberto Jose Lopez-JimenezCenter for Matrix Biology, Vanderbilt University Medical Center, Nashville, TN 37232, USA.
Scott HoughtalingCenter for Developmental Biology and Regenerative Medicine, Seattle Children's Research Institute, Seattle,  WA 98105, USA.
Tzu-Hua HoCenter for Developmental Biology and Regenerative Medicine, Seattle Children's Research Institute, Seattle,  WA 98105, USA.
Roberto VanacoreCenter for Matrix Biology, Vanderbilt University Medical Center, Nashville, TN 37232, USA.
David R BeierCenter for Developmental Biology and Regenerative Medicine, Seattle Children's Research Institute, Seattle,  WA 98105, USA david.beier@seattlechildrens.org.ORCID 0000-0002-0325-8520
Seattle Children's Hospital · USVanderbilt University Medical Center · US

Funding

Mutagenesis and Murine Embyonic DevelopmentR01HD036404 · NICHD · SEATTLE CHILDREN'S HOSPITAL · PI BEIER, DAVID R. · 1998 to 2020
$8.1M
The role of lysyl oxidase like-2 in chronic kidney diseaseR01DK099467 · NIDDK · VANDERBILT UNIVERSITY MEDICAL CENTER · PI VANACORE, ROBERTO MARCELO · 2013 to 2023
$3.8M
NICHD NIH HHS R01 HD036404NIDDK NIH HHS R01 DK099467
6 · The paper itself

Abstract

In a screen for organogenesis defects in N-ethyl-N-nitrosourea (ENU)-induced mutant mice, we discovered a line carrying a mutation in

Indexed as

Protein Processing, Post-TranslationalAllelesAnimalsCollagenEmbryo, MammalianExtracellular MatrixFibroblastsGalactosyltransferasesGlycosylationLoss of Function MutationMiceMolecular WeightMusclesMusculoskeletal SystemMutation, MissensePhenotypecolgalt1a protein, zebrafishColgalt1 protein, mouseCollagenGalactosyltransferasesZebrafish ProteinsCollagen glycosylationCollagenopathiesENUGLT25D1Myopathy

Identifiers

PMID31101663
PMCPMC6602307
OpenAlexW2945971102

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.