ArticleScientific reports2019
IL-1α promotes liver inflammation and necrosis during blood-stage Plasmodium chabaudi malaria.
Article in Scientific reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed.
- Differential expression ofVeterinary world · 2025Article
- Morphometric analysis and immunobiological investigation ofOpen life sciences · 2025Article
- The intersection of hostMicrobiology and molecular biology reviews : MMBR · 2024Review
- Malaria blood stage infection suppresses liver stage infection via host-induced interferons but not hepcidin.Nature communications · 2024Article
- Screening of Multitarget Compounds against Acetaminophen Hepatic Toxicity Using In Silico, In Vitro, and In Vivo Approaches.Molecules (Basel, Switzerland) · 2024Article
- Article
- Cellular iron governs the host response to malaria.PLoS pathogens · 2023Article
- Genome-wide liver transcriptomic profiling of a malaria mouse model reveals disturbed immune and metabolic responses.Parasites & vectors · 2023Article
- Exposure to common infections may shape basal immunity and potentially HIV-1 acquisition amongst a high-risk population in Coastal Kenya.Frontiers in immunology · 2023Article
- MicroRNAs: master regulators in host-parasitic protist interactions.Open biology · 2022Review
- Article
- Review
- Inadvertent nucleotide sequence alterations during mutagenesis: highlighting the vulnerabilities in mouse transgenic technology.Journal, genetic engineering & biotechnology · 2021Article
- Recent Advances in Understanding the Inflammatory Response in Malaria: A Review of the Dual Role of Cytokines.Journal of immunology research · 2021Review
- Mediterranean Diet: Lipids, Inflammation, and Malaria Infection.International journal of molecular sciences · 2020Review
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Authors and funding
11 authors.
Funding
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Abstract
Malaria causes hepatic inflammation and damage, which contribute to disease severity. The pro-inflammatory cytokine interleukin (IL)-1α is released by non-hematopoietic or hematopoietic cells during liver injury. This study established the role of IL-1α in the liver pathology caused by blood-stage P. chabaudi malaria. During acute infection, hepatic inflammation and necrosis were accompanied by NLRP3 inflammasome-independent IL-1α production. Systemically, IL-1α deficiency attenuated weight loss and hypothermia but had minor effects on parasitemia control. In the liver, the absence of IL-1α reduced the number of TUNEL
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