Evidence map›Paper›PMID 31111407›Full record

SynthesisJournal of endocrinological investigation2019

Very-low-calorie ketogenic diet (VLCKD) in the management of metabolic diseases: systematic review and consensus statement from the Italian Society of Endocrinology (SIE).

M Caprio, M Infante, E Moriconi, A Armani, A Fabbri, G Mantovani, S Mariani, C Lubrano, E Poggiogalle, S Migliaccio and 27 more

5 registry-linked trialsAbstract readSystematic ReviewConsensus Statement
PubMed Publisher
In one paragraph

Synthesis in Journal of endocrinological investigation, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 5 registered trials, which are not on this map. Cited by 174 papers, 10 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
174citing papers in PubMed, 10 pooled it
15.7field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04801173 nacompletednot on this mapstarted 2021, after this paper: background citation

Effect of Very Low Calorie Ketogenic Diet on Obese and Insulin-resistant Women With Polycystic Ovary Syndrome: a Controlled Randomized Trial

TypeinterventionalSponsorIRCCS Azienda Ospedaliero-Universitaria di BolognaRan2021 to 2021Enrolled30ConditionsPCOS, Obesity, Insulin ResistanceArmsVery low calorie ketogenic diet, Low calorie standard diet
NCT05275608 narecruitingnot on this mapstarted 2022, after this paper: background citation

Effects of Very Low Calorie Ketogenic Diet on Microbiota, Adipose Tissue and Immunitary Regulation: Pilot Study on Patients with Metabolic Syndrome

TypeinterventionalSponsorAzienda Ospedaliero Universitaria Maggiore della CaritaRan2022 to 2025Enrolled40ConditionsDiabetes Mellitus, Type 2, Non-alcoholic Fatty Liver Disease, Obesity, Metabolic SyndromeArmsVLCKD diet with replacing meals, Hypocaloric mediterranean Diet
NCT05781269 naactive not recruitingnot on this mapstarted 2022, after this paper: background citation

Metabolic Syndrome and Severe Obesity: Randomized Nutritional Trial to Study Long Term Effect of Very-low-calories Ketogenic Diet (VLCKD) on Weight Control and Cardiovascular Risk Factors

TypeinterventionalSponsorIstituto Auxologico ItalianoRan2022 to 2026Enrolled100ConditionsObesity, Morbid ObesityArmsVLCKD, r-MedDiet
NCT07041684 nacompletednot on this mapstarted 2024, after this paper: background citation

Microbiota and Lipedema: Weight Loss, Metabolic and Inflammatory Pattern, and Quality of Life in Obese Patients Before and After Treatment With Very Low Energy Ketogenic Vegan Therapy

TypeinterventionalSponsorUniversity of Roma La SapienzaRan2024 to 2024Enrolled20ConditionsLipedema, Obesity, DysbiosisArmsVery Low Energy Ketogenic Therapy with vegan meal replacements
NCT07389122 completednot on this mapstarted 2021, after this paper: background citation

KOBE Study: Adherence to and Tolerability of Different Very-low-calorie Ketogenic Protocols in Patients With Obesity and Complicated Overweight.

Typeobservational_patient_registrySponsorUniversity of BolognaRan2021 to 2025Enrolled110ConditionsObesity & Overweight, MASLD/MASH (Metabolic Dysfunction-Associated Steatotic Liver Disease / Metabolic Dysfunction-Associated Steatohepatitis), Type 2 Diabetes, Insulin Resistance
3 · Its place in the literature

Who cites it

174 citing papers in PubMed, 10 syntheses or guidelines pooled it, 288 citations in OpenAlex.

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114 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

37 authors at 16 institutions in 1 country.

M CaprioLaboratory of Cardiovascular Endocrinology, IRCCS San Raffaele Pisana, Via di Val Cannuta 247, 00166, Rome, Italy. massimiliano.caprio@sanraffaele.it.
M InfanteUnit of Endocrinology and Metabolic Diseases, Department of Systems Medicine, CTO A. Alesini Hospital, ASL Roma 2, University of Rome Tor Vergata, Rome, Italy.
E MoriconiLaboratory of Cardiovascular Endocrinology, IRCCS San Raffaele Pisana, Via di Val Cannuta 247, 00166, Rome, Italy.
A ArmaniLaboratory of Cardiovascular Endocrinology, IRCCS San Raffaele Pisana, Via di Val Cannuta 247, 00166, Rome, Italy.
A FabbriUnit of Endocrinology and Metabolic Diseases, Department of Systems Medicine, CTO A. Alesini Hospital, ASL Roma 2, University of Rome Tor Vergata, Rome, Italy.
G MantovaniFondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Endocrinology and Diabetology Unit, Department of Clinical Sciences and Community Health, University of Milan, Milan, Italy.
S MarianiSection of Medical Pathophysiology, Food Science and Endocrinology, Department of Experimental Medicine, Sapienza University of Rome, Rome, Italy.
C LubranoSection of Medical Pathophysiology, Food Science and Endocrinology, Department of Experimental Medicine, Sapienza University of Rome, Rome, Italy.
E PoggiogalleSection of Medical Pathophysiology, Food Science and Endocrinology, Department of Experimental Medicine, Sapienza University of Rome, Rome, Italy.
S MigliaccioSection of Health Sciences, Department of Movement, Human and Health Sciences, "Foro Italico" University of Rome, Rome, Italy.
L M DoniniSection of Medical Pathophysiology, Food Science and Endocrinology, Department of Experimental Medicine, Sapienza University of Rome, Rome, Italy.
S BascianiSection of Medical Pathophysiology, Food Science and Endocrinology, Department of Experimental Medicine, Sapienza University of Rome, Rome, Italy.
A CignarelliSection of Internal Medicine, Endocrinology, Andrology and Metabolic Diseases, Department of Emergency and Organ Transplantation, University of Bari Aldo Moro, Bari, Italy.
E ConteSection of Internal Medicine, Endocrinology, Andrology and Metabolic Diseases, Department of Emergency and Organ Transplantation, University of Bari Aldo Moro, Bari, Italy.
G CeccariniEndocrinology Unit, Obesity and Lipodystrophy Center, University Hospital of Pisa, Pisa, Italy.
F BogazziEndocrinology Unit, Department of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy.
L CiminoDepartment of Clinical and Experimental Medicine, University of Catania, Catania, Italy.
R A CondorelliDepartment of Clinical and Experimental Medicine, University of Catania, Catania, Italy.
S La VigneraDepartment of Clinical and Experimental Medicine, University of Catania, Catania, Italy.
A E CalogeroDepartment of Clinical and Experimental Medicine, University of Catania, Catania, Italy.
A GambineriEndocrinology Unit and Center for Applied Biomedical Research, Department of Medical and Surgical Sciences, University of Bologna, S. Orsola-Malpighi Hospital, Bologna, Italy.
L VignozziAndrology, Women's Endocrinology and Gender Incongruence Unit, Department of Biomedical, Experimental and Clinical Sciences, University of Florence, AOU Careggi, Florence, Italy.
F ProdamEndocrinology, Department of Translational Medicine and Department of Health Sciences, University of Piemonte Orientale, Novara, Italy.
G AimarettiEndocrinology, Department of Translational Medicine and Department of Health Sciences, University of Piemonte Orientale, Novara, Italy.
G LinsalataGeriatrics Unit, Department of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy.
S BuralliGeriatrics Unit, Department of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy.
F MonzaniGeriatrics Unit, Department of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy.
A AversaDepartment of Experimental and Clinical Medicine, Magna Graecia University of Catanzaro, Catanzaro, Italy.
R VettorDepartment of Medicine, Internal Medicine 3, University Hospital of Padova, Padua, Italy.
F SantiniEndocrinology Unit, Obesity and Lipodystrophy Center, University Hospital of Pisa, Pisa, Italy.
P VittiEndocrinology Unit, Department of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy.
L GnessiSection of Medical Pathophysiology, Food Science and Endocrinology, Department of Experimental Medicine, Sapienza University of Rome, Rome, Italy.
U PagottoEndocrinology Unit and Center for Applied Biomedical Research, Department of Medical and Surgical Sciences, University of Bologna, S. Orsola-Malpighi Hospital, Bologna, Italy.
F GiorginoSection of Internal Medicine, Endocrinology, Andrology and Metabolic Diseases, Department of Emergency and Organ Transplantation, University of Bari Aldo Moro, Bari, Italy.
A ColaoSection of Endocrinology, Department of Clinical Medicine and Surgery, University "Federico II" of Naples, Naples, Italy.
A LenziSection of Medical Pathophysiology, Food Science and Endocrinology, Department of Experimental Medicine, Sapienza University of Rome, Rome, Italy.
Cardiovascular Endocrinology Club of the Italian Society of Endocrinology
Sapienza University of Rome · ITUniversity of Pisa · ITUniversity of Catania · ITUniversity of Bari Aldo Moro · ITAzienda Ospedaliera Universitaria Pisana · ITIRCCS Azienda Ospedliero-Universitaria di Bologna Policlinico di Sant'Orsola · ITIRCCS Ospedale San Raffaele · ITUniversità degli Studi del Piemonte Orientale “Amedeo Avogadro” · ITUniversity of Rome Tor Vergata · ITForo Italico University of Rome · ITMagna Graecia University · ITUniversity of Florence · ITUniversity of Milan · ITUniversity of Naples Federico II · ITUniversity of Padua · ITVita-Salute San Raffaele University · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundWeight loss is a milestone in the prevention of chronic diseases associated with high morbility and mortality in industrialized countries. Very-low calorie ketogenic diets (VLCKDs) are increasingly used in clinical practice for weight loss and management of obesity-related comorbidities. Despite evidence on the clinical benefits of VLCKDs is rapidly emerging, some concern still exists about their potential risks and their use in the long-term, due to paucity of clinical studies. Notably, there is an important lack of guidelines on this topic, and the use and implementation of VLCKDs occurs vastly in the absence of clear evidence-based indications. PURPOSE: We describe here the biochemistry, benefits and risks of VLCKDs, and provide recommendations on the correct use of this therapeutic approach for weight loss and management of metabolic diseases at different stages of life.

Indexed as

EndocrinologyConsensusDiet, KetogenicDiet, ReducingHumansMetabolic DiseasesObesitySocieties, MedicalCardiovascular rehabilitationCardiovascular riskKetone bodiesObesityType 2 diabetesWeight loss

Identifiers

PMID31111407
OpenAlexW2945358180

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.