Evidence map›Paper›PMID 31111411›Full record

SynthesisSleep & breathing = Schlaf & Atmung2020

The prevalence of obstructive sleep apnoea in women with polycystic ovary syndrome: a systematic review and meta-analysis.

Hassan Kahal, Ioannis Kyrou, Olalekan A Uthman, Anna Brown, Samantha Johnson, Peter D H Wall, Andrew Metcalfe, David G Parr, Abd A Tahrani, Harpal S Randeva

Open access · hybridAbstract readMeta-AnalysisSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Sleep & breathing = Schlaf & Atmung, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
46citing papers in PubMed, 5 pooled it
4.8field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

46 citing papers in PubMed, 5 syntheses or guidelines pooled it, 79 citations in OpenAlex.

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  20. Effect of obstructive sleep apnea on in vitro fertilization outcomes in women with polycystic ovary syndrome.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 1 country.

Hassan KahalDivision of Translational and Experimental Medicine, Warwick Medical School, University of Warwick, Coventry, CV4 7AL, UK.
Ioannis KyrouDivision of Translational and Experimental Medicine, Warwick Medical School, University of Warwick, Coventry, CV4 7AL, UK.
Olalekan A UthmanWarwick - Centre for Applied Health Research and Delivery (WCAHRD), Division of Health Sciences, Warwick Medical School, University of Warwick, Coventry, CV4 7AL, UK.
Anna BrownLibrary and Knowledge Services, University Hospitals Coventry and Warwickshire NHS Trust, Coventry, CV2 2DX, UK.
Samantha JohnsonUniversity of Warwick Library, University of Warwick, Coventry, CV4 7AL, UK.
Peter D H WallDepartment of Warwick Orthopaedics, Warwick Medical School, University of Warwick, Coventry, CV2 2DX, UK.
Andrew MetcalfeDepartment of Warwick Orthopaedics, Warwick Medical School, University of Warwick, Coventry, CV2 2DX, UK.
David G ParrDepartment of Respiratory Medicine, Cardio-Respiratory Division, University Hospitals Coventry and Warwickshire NHS Trust, Coventry, CV2 2DX, UK.
Abd A TahraniInstitute of Metabolism and Systems Research, College of Medical and Dental Sciences, University of Birmingham, Birmingham, B15 2TT, UK.
Harpal S RandevaDivision of Translational and Experimental Medicine, Warwick Medical School, University of Warwick, Coventry, CV4 7AL, UK. Harpal.Randeva@warwick.ac.uk.
University Hospitals Coventry and Warwickshire NHS Trust · GBUniversity of Warwick · GBCoventry University · GBUniversity of Birmingham · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundObesity is a common risk factor for polycystic ovary syndrome (PCOS) and obstructive sleep apnoea (OSA). Both PCOS and OSA are associated with increased risk of type 2 diabetes and cardiovascular disease. Hence, it is important to determine the burden of OSA in women with PCOS.

methodsWe searched electronic databases (MEDLINE, Embase, CINAHL, PsycINFO, Scopus, Web of Science, OpenGrey, CENTRAL), conference abstracts, and reference lists of relevant articles, up to January 2019. No restriction for language or publication status. Studies that examined the presence of OSA in women with PCOS using polysomnography and/or level III devices were eligible for inclusion.

resultsSeventeen studies involving 648 participants were included. Our meta-analysis showed that 35.0% (95% CI 22.2-48.9%) of women with PCOS had OSA. This prevalence was not affected by variation in PCOS definition between studies. Approximately one-tenth of the variation in OSA prevalence was related to differences in study population (higher in adults than adolescents and mixed populations), and around one-tenth was related to sample size (higher in smaller studies). OSA prevalence was markedly higher in obese versus lean women with PCOS, and in women with PCOS compared to controls (odds ratio = 3.83, 95% CI 1.43-10.24, eight studies, 957 participants (349 PCOS and 608 controls)). However, most of the studies were at high risk of selection bias, did not account for important confounders, included predominantly women with class II obesity, and were conducted in one country (USA).

conclusionsFuture studies need to examine the true prevalence of OSA in a more representative sample of women with PCOS. Nevertheless, our results suggest that the prevalence of OSA in women with PCOS and obesity is high and clinicians should have a high index of suspicion of OSA in these women.

Indexed as

AdolescentAdultComorbidityCross-Sectional StudiesFemaleHumansObesityOdds RatioPolycystic Ovary SyndromePolysomnographyRisk FactorsSleep Apnea, ObstructiveYoung AdultHyperandrogenismInsulin resistanceObesityOSAPCOS

Identifiers

PMID31111411
PMCPMC7127997
OpenAlexW3013329539

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.